| | |
Q1
|
Combined middle half
|
Q4
|
P
-trend
|
P
-interaction
|
|---|
|
Serum TMAO
|
|
HBV infectionb
|
|
Yes
|
n (Cases/Controls)
|
76/15
|
333/30
|
173/15
| |
0.095
|
|
OR (95% CI) a
|
1.00
|
1.83 (0.89–3.78)
|
2.07 (0.91–4.74)
|
0.104
|
|
No
|
n (Cases/Controls)
|
8/152
|
53/306
|
28/153
| |
|
OR (95% CI) a
|
1.00
|
3.82 (1.63–8.94)
|
3.73 (1.50–9.30)
|
0.006
|
|
Alcohol usingb
|
|
Yes
|
n (Cases/Controls)
|
13/21
|
121/43
|
52/21
| |
0.777
|
|
OR (95% CI) a
|
1.00
|
2.54 (0.74–8.68)
|
3.44 (0.88–13.54)
|
0.092
|
|
No
|
n (Cases/Controls)
|
51/145
|
274/295
|
160/146
| |
|
OR (95% CI) a
|
1.00
|
3.10 (1.69–5.67)
|
3.57 (1.83–6.96)
|
0.001
|
|
Smokingb
|
|
Yes
|
n (Cases/Controls)
|
41/68
|
175/136
|
86/68
| |
0.024
|
|
OR (95% CI) a
|
1.00
|
1.32 (0.59–2.94)
|
1.47 (0.60–3.60)
|
0.418
|
|
No
|
n (Cases/Controls)
|
30/99
|
209/200
|
130/100
| |
|
OR (95% CI) a
|
1.00
|
3.92 (1.84–8.35)
|
4.88 (2.13–11.19)
|
0.001
|
|
Sexb
|
|
Men
|
n (Cases/Controls)
|
74/140
|
312/287
|
183/142
| |
0.166
|
|
OR (95% CI) a
|
1.00
|
2.04 (1.16–3.60)
|
2.28 (1.22–4.26)
|
0.016
|
|
Women
|
n (Cases/Controls)
|
7/25
|
52/52
|
43/25
| |
|
OR (95% CI) a
|
1.00
|
1.79 (0.38–8.30)
|
5.23 (1.05–26.10)
|
0.021
|
|
Metabolic syndromeb
|
|
Yes
|
n (Cases/Controls)
|
14/43
|
75/88
|
39/43
| |
0.473
|
|
OR (95% CI) a
|
1.00
|
3.04 (0.92–10.01)
|
3.45 (0.94–12.65)
|
0.095
|
|
No
|
n (Cases/Controls)
|
50/124
|
307/249
|
186/124
| |
|
OR (95% CI) a
|
1.00
|
2.50 (1.35–4.62)
|
2.83 (1.44–5.59)
|
0.006
|
|
Serum Choline
|
|
HBV infectionb
|
|
Yes
|
n (Cases/Controls)
|
368/15
|
151/30
|
63/15
| |
0.121
|
|
OR (95% CI) a
|
1.00
|
0.22 (0.11–0.46)
|
0.22 (0.09–0.50)
|
< 0.001
|
|
No
|
n (Cases/Controls)
|
52/152
|
33/306
|
4/153
| |
|
OR (95% CI) a
|
1.00
|
0.24 (0.14–0.43)
|
0.05 (0.02–0.16)
|
< 0.001
|
|
Alcohol usingb
|
|
Yes
|
n (Cases/Controls)
|
137/21
|
36/43
|
13/21
| |
0.145
|
|
OR (95% CI) a
|
1.00
|
0.13 (0.05–0.37)
|
0.21 (0.05–0.90)
|
0.001
|
|
No
|
n (Cases/Controls)
|
304/146
|
154/294
|
27/146
| |
|
OR (95% CI) a
|
1.00
|
0.34 (0.21–0.56)
|
0.13 (0.06–0.27)
|
< 0.001
|
|
Smokingb
|
|
Yes
|
n (Cases/Controls)
|
200/68
|
69/136
|
33/68
| |
0.001
|
|
OR (95% CI) a
|
1.00
|
0.16 (0.08–0.34)
|
0.21 (0.08–0.53)
|
< 0.001
|
|
No
|
n (Cases/Controls)
|
228/98
|
123/201
|
18/100
| |
|
OR (95% CI) a
|
1.00
|
0.37 (0.21–0.64)
|
0.12 (0.05–0.27)
|
< 0.001
|
|
Sexb
|
|
Men
|
n (Cases/Controls)
|
361/141
|
161/286
|
47/142
| |
0.008
|
|
OR (95% CI) a
|
1.00
|
0.23 (0.14–0.38)
|
0.20 (0.10–0.38)
|
< 0.001
|
|
Women
|
n (Cases/Controls)
|
69/25
|
30/52
|
3/25
| |
|
OR (95% CI) a
|
1.00
|
0.34 (0.11–1.10)
|
0.01 (0.00–0.08)
|
< 0.001
|
|
Metabolic syndromeb
|
|
Yes
|
n (Cases/Controls)
|
94/43
|
31/88
|
3/43
| |
0.050
|
|
OR (95% CI) a
|
1.00
|
0.09 (0.03–0.26)
|
0.01 (0.00–0.10)
|
< 0.001
|
|
No
|
n (Cases/Controls)
|
329/124
|
169/249
|
45/124
| |
|
OR (95% CI)a
|
1.00
|
0.32 (0.19–0.53)
|
0.20 (0.10–0.40)
|
< 0.001
|
- aAdjusted for age, sex, BMI, household income, occupation, marital status, smoking status, alcohol use, presence of metabolic syndrome, and HBV infection status
- bStratified factors were not included in the corresponding model
