Fig. 6
Proposed scheme illustrating the role of SCLE on lipid metabolism. SCLE possibly reduced lipid accumulation through the following process: I: increased AMPK phosphorylation to inhibit the expression of SREBP-2 and the target gene HMG-CoAR; II: the AMPK phosphorylation also stimulated the ATGL, HSL expression and the phosphorylation of HSL to modulate hydrolysis of triglyceride; III: enhanced the activity and expression of CAT and ACO to promote fatty acid β-oxidation. AMPK, AMP-activated protein kinase; p-AMPK; phosphorylated AMPK; SREBP-2, sterol regulatory element binding protein-2; HMG-CoAR, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; ATGL, adipose triglyceride lipase; p-HSL; phosphorylated HSL; CAT, carnitine acyltransferase; ACO, acyl-CoA oxidase; TG, triglyceride; DG, diglyceride; MG, monoglyceride; FA, fatty acid; FA-CoA, fatty acid CoA. 
 and → denote stimulation; 
 and ˨ denote inhibition