Table 1 Protein identification by LC/MS/MS of spots in 2DE gels of 3 day mice hypothalamus which were significantly different in averaged normalised volume in HFD compared to LFD mice (n = 6). Proteins are arranged into 4 broad categories associated with specific functions: Proteins Associated with Cytoskeleton and/or Neuronal Plasticity, Proteins Associated with Cellular Stress, Proteins Associated with Energy Metabolism, all remaining proteins are grouped under Proteins Associated with Other Functions. Proteins belonging in more than one category are marked with an asterix (*) next to their UniProtKB identifier References for Table 1 can be found in Additional file 3
From: A high-fat diet induces rapid changes in the mouse hypothalamic proteome
Spot # | Anova (p) | Fold Change | Protein Name | pI | MW | Average Normalised Volumes | Other Functional Categories | MASCOT Data | UniProtKB | |
|---|---|---|---|---|---|---|---|---|---|---|
Low Fat | High Fat | |||||||||
Proteins Associated with Cytoskeleton and/or Neuronal Plasticity | ||||||||||
24 | 8.14E-04 | 1.2 | Dihydropyrimidinase-related protein 2 | 6.48 | 71,179 | 785,600 | 644,200 | ●Alzheimer’s disease/Neuronal degeneration (s1-s7) | Score: 56 Matches: 5(3) Sequences: 5(3) | O08553 |
33a | 1.00E-03 | 1.3 | 6.46 | 67,358 | 431,700 | 342,400 | Score: 56 Matches: 5(3) Sequences: 5(3) | |||
33b | 8.00E-03 | 1.6 | 6.38 | 64,410 | 41,860 | 25,450 | Score: 56 Matches: 5(3) Sequences: 5(3) | |||
22 | 2.00E-03 | 1.2 | 6.07 | 75,305 | 345,200 | 426,100 | Score: 54 Matches: 5(2) Sequences: 5(2) | |||
34 | 4.00E-03 | 1.4 | 6.58 | 66,703 | 130,200 | 92,110 | Score: 96 Matches: 6(2) Sequences: 6(2) | |||
27 | 7.00E-03 | 1.2 | 6.72 | 69,760 | 1,976,000 | 1,616,000 | Score: 555 Matches: 68(37) Sequences: 17(13) | |||
90 | 9.00E-03 | 1.2 | 6.58 | 70,524 | 660,200 | 534,100 | Score: 446 Matches: 50(25) Sequences: 16(14) | |||
25 | 1.90E-02 | 1.5 | 6.59 | 74,017 | 115,700 | 75,120 | Score: 66 Matches: 5(2) Sequences: 5(2) | |||
23 | 3.70E-02 | 1.4 | 6.35 | 72,817 | 26,820 | 36,860 | Score: 159 Matches: 17(10) Sequences:12(9) | |||
92 | 1.50E-02 | 1.2 | Dihydropyrimidinase-related protein 1 | 7.27 | 67,795 | 342,400 | 274,800 | Score: 104 Matches: 14(5) Sequences: 12(5) | P97427 | |
35 | 3.50E-02 | 1.4 | Dihydropyrimidinase-related protein 5 | 8.18 | 71,943 | 553,000 | 752,200 | (s8) | Score: 44 Matches: 4(1) Sequences: 4(1) emPAI: 0.06 | Q9EQF6 |
37 | 1.00E-03 | 1.5 | Fascin | 6.65 | 54,476 | 202,200 | 137,500 | ●Astrocyte specific ●Alzheimer’s disease/Neuronal degeneration (s9-s11) | Score: 51 Matches: 2(1) Sequences: 2(1) | Q61553 |
125 | 4.00E-03 | 1.5 | 6.64 | 56,114 | 66,550 | 44,030 | Score: 51 Matches: 2(1) Sequences: 2(1) | |||
86 | 1.00E-03 | 1.4 | Thrombospondin type-1 domain-containing protein 1 | 6.44 | 89,787 | 21,030 | 14,960 | ●Cellular stress ●Astrocyte specific ●Alzheimer’s disease/Neuronal degeneration (s13) | Score: 36 Matches: 3(1) Sequences: 1(1) | Q9JM61* |
17 | 2.00E-03 | 1.4 | Contactin-2 | 6.16 | 77,287 | 157,100 | 214,400 | ●Alzheimer’s disease/Neuronal degeneration (s14) | Score: 35 Matches: 1(1) Sequences: 1(1) | Q61330 |
88 | 3.00E-03 | 1.4 | Dynamin-1-like protein | 6.65 | 88,262 | 44,130 | 31,300 | ●Cellular stress ●Mitochondrial (s15,s16) | Score: 56 Matches: 6(4) Sequences: 6(4) | Q8K1M6* |
87 | 1.90E-02 | 1.4 | 6.52 | 88,872 | 44,600 | 32,400 | Score: 37 Matches: 2(1) Sequences: 2(1) | |||
85 | 1.90E-02 | 1.3 | 7.21 | 91,921 | 31,110 | 24,030 | Score: 53 Matches: 4(2) Sequences: 4(2) | |||
52 | 4.00E-03 | 1.7 | F-actin-capping protein subunit alpha-1 | 6.06 | 35,065 | 33,650 | 55,680 | ●Alzheimer’s disease/Neuronal degeneration (s17, s18) | Score: 82 Matches: 1(1) Sequences: 1(1) e | P47753 |
58 | 1.00E-02 | 1.2 | F-actin-capping protein subunit β | 6 | 29,413 | 633,600 | 780,600 | Score: 80 Matches: 6(2) Sequences: 6(2) | P47757 | |
124 | 4.00E-03 | 1.3 | Fatty acid-binding protein, brain | 5.69 | 12,708 | 329,600 | 413,500 | ●Cellular stress ●Astrocyte specific ●Alzheimer’s disease/Neuronal degeneration (s19-s21) | Score: 47 Matches: 2(1) Sequences: 2(1) | P51880* |
99 | 4.00E-03 | 1.3 | Dual specificity mitogen-activated protein kinase kinase 1 | 6.78 | 45,886 | 588,200 | 453,000 | ●Alzheimer’s disease/Neuronal degeneration (s22-s24) | Score: 100 Matches: 7(4) Sequences: 6(4) | P31938 |
82 | 5.00E-03 | 2 | Profilin-1 | 9.98 | 12,625 | 23,210 | 47,490 | ●Alzheimer’s disease/Neuronal degeneration (s25-s28) | Score: 73 Matches: 5(2) Sequences: 3(2) | P62962 |
122 | 7.00E-03 | 1.5 | Profilin-2 | 5.65 | 13,875 | 115,800 | 171,500 | Score: 62 Matches: 2(2) Sequences: 2(2) | Q9JJV2 | |
96 | 8.00E-03 | 1.5 | Actin-related protein 3 | 6.18 | 50,983 | 31,780 | 47,350 | ●Alzheimer’s disease/Neuronal degeneration (s29) | Score: 47 Matches: 4(1) Sequences: 4(1) | Q99JY9 |
93 | 1.20E-02 | 1.5 | Plastin-3 | 6.09 | 68,341 | 25,000 | 36,730 | ●Alzheimer’s disease/Neuronal degeneration (s30) | Score: 65 Matches: 5(3) Sequences: 5(3) | Q99K51 |
76 | 1.50E-02 | 1.4 | Nucleoside diRAphosphate kinase A | 7.14 | 15,333 | 279,200 | 205,400 | ●Alzheimer’s disease/Neuronal degeneration (s31, s32) | Score: 101 Matches: 15(8) Sequences: 6(4) emPAI: 1.23 | P15532 |
116 | 1.70E-02 | 1.3 | GTP-binding nuclear protein Ran | 7.61 | 24,820 | 524,100 | 398,300 | ●Alzheimer’s disease/Neuronal degeneration (s33, s34) | Score: 131 Matches: 11(5) Sequences: 6(4) | P62827 |
26 | 2.10E-02 | 1.3 | WD repeat-containing protein 1 | 6.89 | 73,690 | 146,600 | 116,800 | (s35, s36) | W Score: 65 Matches: 11(3) Sequences: 8(3) | O88342 |
55 | 2.30E-02 | 1.2 | T Tropomyosin alpha-1 chain | 4.72 | 30,497 | 340,400 | 407,500 | ●Alzheimer’s disease/Neuronal degeneration (s37, s38) | Score: 70 Matches: 3(3) Sequences: 3(3) | P58771 |
89 | 2.10E-02 | 1.2 | 6.47 | 87,348 | 30,950 | 25,160 | Score: 119 Matches: 9(3) Sequences: 9(3) | |||
69 | 2.60E-02 | 1.2 | Stathmin | 6.07 | 16,606 | 642,900 | 761,200 | ●Alzheimer’s disease/Neuronal degeneration (s39, s40) | Score: 36 Matches: 2(1) Sequences: 2(1) | P54227 |
60 | 2.60E-02 | 1.3 | Talin-2 | 6.66 | 31,968 | 63,640 | 47,710 | (s41) | Score: 34 Matches: 2(1) Sequences: 2(1) | Q71LX4 |
63 | 2.70E-02 | 1.4 | Sepiapterin reductase | 6.05 | 26,394 | 111,900 | 157,000 | ●Alzheimer’s disease/Neuronal degeneration (s42) | Score: 34 Matches: 2(1) Sequences: 2(1) | Q64105 |
74 | 3.10E-02 | 1.2 | Spastin | 4.91 | 15,061 | 311,900 | 375,100 | ●Alzheimer’s disease/Neuronal degeneration (s43-s45) | Score: 34 Matches: 1(1) Sequences: 1(1) | Q9QYY8 |
71 | 4.80E-02 | 1.1 | Peptidyl-prolyl cis-trans isomerase A | 7.33 | 16,394 | 173,900 | 153,400 | ●Alzheimer’s disease/Neuronal degeneration (s46-s48) | Score: 53 Matches: 4(2) Sequences: 4(2) | P17742 |
67 | 3.80E-02 | 1.1 | Beta-synuclein | 4.13 | 17,576 | 1,879,000 | 2,051,000 | ●Alzheimer’s disease/Neuronal degeneration (s49, s50) | Score: 57 Matches: 2(1) Sequences: 1(1) | Q91ZZ3 |
Proteins Associated with Cellular Stress | ||||||||||
20a | 1.00E-03 | 1.6 | Heat shock 70 kDa protein 12A | 6.68 | 79,878 | 61,440 | 39,140 | ●Alzheimer’s disease/Neuronal degeneration (s51, s52) | Score: 69 Matches: 4(2) Sequences: 4(2) | Q8K0U4 |
20b | 3.00E-03 | 1.5 | 6.71 | 83,079 | 95,300 | 64,690 | Score: 69 Matches: 4(2) Sequences: 4(2) | |||
20c | 1.50E-02 | 1.3 | 6.75 | 80,640 | 119,400 | 88,760 | Score: 69 Matches: 4(2) Sequences: 4(2) | |||
79 | 8.00E-03 | 1.5 | 10 kDa heat shock protein, mitochondrial | 7.29 | 10,958 | 645,800 | 427,900 | ●Mitochondrial (s53) | Score: 47 Matches: 3(1) Sequences: 3(1) | Q64433 |
31 | 2.50E-02 | 1.2 | 60 kDa heat shock protein, mitochondrial | 5.79 | 63,646 | 1,008,000 | 1,245,000 | ●Mitochondrial ●Alzheimer’s disease/Neuronal degeneration (s54) | Score: 604 Matches: 70(41) Sequences: 18(15) | P63038 |
21 | 2.90E-02 | 1.2 | Heat shock cognate 71 kDa protein | 5.73 | 75,915 | 4,300,000 | 5,025,000 | ●Alzheimer’s disease/Neuronal degeneration (s2) | Score: 51 Matches: 7(2) Sequences: 7(2) | P63017 |
42 | 2.90E-02 | 1.3 | 8.07 | 48,958 | 1,434,000 | 1,799,000 | Score: 183 Matches: 10(7) Sequences: 8(6) | |||
19 | 9.00E-03 | 1.3 | Heat shock protein 105 kDa | 6.72 | 88,567 | 67,300 | 50,100 | (s55) | Score: 35 Matches: 1(1) Sequences: 1(1) | Q61699 |
114 | 1.00E-03 | 1.4 | PITH domain-containing protein 1 | 5.95 | 25,039 | 52,050 | 73,410 | Score: 66 Matches: 6(3) Sequences: 6(3) | Q8BWR2 | |
45 | 2.00E-03 | 1.5 | Elongation factor Tu, mitochondrial | 7 | 46,325 | 170,000 | 110,000 | ●Mitochondrial ●Alzheimer’s disease/Neuronal degeneration s56) | Score: 66 Matches: 6(4) Sequences: 6(4) | Q8BFR5 |
165 | 2.00E-03 | 1.3 | Amyloid beta A4 precursor protein-binding family B member 3 | 6.16 | 23,597 | 101,500 | 135,700 | ●Alzheimer’s disease/Neuronal degeneration (s57) | Score: 44 Matches: 7(1) Sequences: 1(1) | Q8R1C9 |
15 | 1.70E-02 | 1.3 | 6.05 | 88,110 | 31,970 | 40,700 | Score: 51 Matches: 8(3) Sequences: 1(1) | |||
38 | 3.80E-02 | 1.4 | 7.25 | 55,131 | 165,400 | 114,700 | Score: 49 Matches: 10(5) Sequences: 3(1) | |||
48 | 8.00E-03 | 1.3 | 6.83 | 41,004 | 128,000 | 95,720 | Score: 55 Matches: 8(3) Sequences: 1(1) | |||
2 | 6.00E-03 | 1.4 | 5.91 | 211,272 | 47,200 | 66,770 | Score: 48 Matches: 11(3) Sequences: 1(1) | |||
8 | 4.00E-03 | 1.4 | Lon protease homolog, mitochondria | 6.78 | 143,046 | 95,550 | 66,140 | ●Mitochondrial (s58) | Score: 50 Matches: 4(2) Sequences: 4(2) | Q8CGK3 |
112 | 5.00E-03 | 1.3 | Biliverdin reductase | 7.26 | 32,355 | 306,500 | 241,400 | ●Alzheimer’s disease/Neuronal degeneration (s59) | Score: 49 Matches: 5(2) Sequences: 5(2) | Q9CY64 |
106 | 6.00E-03 | 1.3 | Pyridoxal kinase | 6.12 | 37,439 | 541,300 | 681,500 | ●Alzheimer’s disease/Neuronal degeneration (s60, s61) | Score: 142 Matches: 11(8) Sequences: 8(7) | Q8K183 |
47 | 9.00E-03 | 1.2 | Serine/threonine-protein phosphatase 2A activator | 6.5 | 40,401 | 325,700 | 261,300 | ●Alzheimer’s disease/Neuronal degeneration (s62) | Score: 55 Matches: 4(1) Sequences: 4(1) | P58389 |
113 | 1.00E-02 | 1.5 | Purine nucleoside phosphorylase | 6.15 | 29,645 | 60,300 | 89,000 | ●Alzheimer’s disease/Neuronal degeneration (s63, s64) | Score: 56 Matches: 6(2) Sequences: 6(2) e | P23492 |
77 | 1.30E-02 | 2 | Peroxiredoxin-5 | 8.69 | 15,091 | 208,000 | 409,900 | ●Mitochondrial ●Alzheimer’s disease/Neuronal degeneration (s65, s66) | Mass: 22226 Score: 181 Matches: 14(9) Sequences: 8(6) | P99029 |
78 | 3.20E-02 | 1.9 | 9.13 | 15,121 | 155,800 | 83,470 | Score: 84 Matches: 9(4) Sequences: 6(4) emPAI: 0.88 | |||
94 | 1.70E-02 | 1.4 | Alpha-aminoadipic semialdehyde dehydrogenase | 6.57 | 59,170 | 56,390 | 41,730 | (67) | Score: 110 Matches: 6(4) Sequences: 6(4) | Q9DBF1 |
49 | 4.00E-02 | 1.7 | Fructose-bisphosphate aldolase C | 8 | 40,291 | 67,960 | 114,800 | ●Glucose metabolism ●Mitochondrial ●Alzheimer’s disease/Neuronal degeneration (s68-s70) | Score: 143 Matches: 8(5) Sequences: 8(5) | P05063* |
95 | 4.20E-02 | 1.3 | Aldehyde dehydrogenase, mitochondrial | 6.79 | 54,367 | 713,100 | 564,900 | ●Mitochondrial ●Alzheimer’s disease/Neuronal degeneration (s71, s72) | Score: 160 Matches: 14(10) Sequences: 11(9) | P47738 |
101 | 4.40E-02 | 1.4 | DNA fragmentation factor subunit alpha | 6.93 | 43,473 | 200,500 | 147,500 | ●Alzheimer’s disease/Neuronal degeneration(s73, 7 s4) | Score: 42 Matches: 1(1) Sequences: 1(1) | O54786 |
Proteins Associated with Energy Metabolism | ||||||||||
13 | 5.09E-04 | 1.2 | Aconitate hydratase, mitochondrial | 7.99 | 93,902 | 617,800 | 528,900 | ●Cellular stress ●Mitochondrial ●Alzheimer’s disease/Neuronal degeneration(s9, s75) | Score: 159 Matches: 16(6) Sequences: 13(6) | Q99KI0* |
53 | 9.00E-03 | 1.5 | Malate dehydrogenase, cytoplasmic | 6.07 | 34,445 | 68,430 | 104,200 | ●Alzheimer’s disease/Neuronal degeneration (s9) | Score: 65 Matches: 4(1) Sequences: 4(1) emPAI: 0.11 | P14152 |
108 | 1.50E-02 | 1.2 | 6.46 | 37,603 | 129,700 | 104,000 | Score: 62 Matches: 2(1) Sequences: 2(1) | |||
109 | 7.00E-03 | 1.2 | 6.53 | 34,252 | 3,506,000 | 2,996,000 | Score: 435 Matches: 39(24) Sequences: 10(7) | |||
104 | 7.00E-03 | 1.3 | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 6.06 | 41,608 | 130,800 | 164,600 | ●Mitochondrial ●Alzheimer’s disease/Neuronal degeneration (s76, s77) | Score: 73 Matches: 6(3) Sequences: 6(3) | Q9D6R2 |
105 | 7.00E-03 | 1.2 | 6.04 | 40,456 | 647,600 | 774,800 | Score: 205 Matches: 21(12) Sequences: 13(8) | |||
117 | 9.00E-03 | 1.9 | Triosephosphate isomerase | 8.56 | 26,200 | 94,250 | 178,000 | ●Alzheimer’s disease/Neuronal degeneration (s78, s79) | Score: 128 Matches: 13(7) Sequences: 6(5) | P17751 |
41 | 1.00E-02 | 1.2 | Alpha-enolase | 6.89 | 48,793 | 3,024,000 | 2,527,000 | ●Alzheimer’s disease/Neuronal degeneration (s75, s80) | Score: 310 Matches: 55(26) Sequences: 15(12) | P17182 |
40 | 1.70E-02 | 1.3 | 6.66 | 49,013 | 1,724,000 | 1,284,000 | Score: 125 Matches: 17(9) Sequences: 11(7) | |||
97 | 1.20E-02 | 2.5 | Pyruvate kinase | 8.82 | 48,848 | 47,750 | 117,800 | ●Alzheimer’s disease/Neuronal degeneration (s81) | Score: 121 Matches: 14(8) Sequences: 10(7) | P52480 |
49 | 2.60E-02 | 1.2 | Phosphoglucomutase-1 | 7.02 | 67,904 | 384,900 | 309,800 | ●Alzheimer’s disease/Neuronal degeneration (s82, s83) | Score: 349 Matches: 28(18) Sequences: 20(17) | Q9D0F9 |
110 | 2.70E-02 | 1.4 | Glycerol-3-phosphate dehydrogenase 1-like protein | 7 | 39,084 | 138,600 | 99,230 | ●Alzheimer’s disease/Neuronal degeneration (s84) | Score: 160 Matches: 12(7) Sequences: 11(7) | Q3ULJ0 |
49 | 4.00E-02 | 1.7 | Fructose-bisphosphate aldolase C | 8 | 40,291 | 67,960 | 114,800 | ●Cellular stress ●Mitochondrial ●Alzheimer’s disease/Neuronal degeneration (s68-s71) | Score: 143 Matches: 8(5) Sequences: 8(5) | P05063* |
64 | 4.30E-02 | 1.2 | Phosphoglycerate mutase 1 | 7.32 | 27,981 | 999,700 | 830,600 | ●Alzheimer’s disease/Neuronal degeneration(s85) | Score: 127 Matches: 12(5) Sequences: 6(4) | Q9DBJ1 |
Protein Associated with Other Functions | ||||||||||
107 | 5.94E-04 | 1.4 | Glycine--tRNA ligase | 6.47 | 81,250 | 112,900 | 79,050 | Protein synthesis ●Alzheimer’s disease/Neuronal degeneration (s86) | Score: 82 Matches: 10(4) Sequences: 9(4) | Q9CZD3 |
98 | 8.10E-04 | 1.5 | RNA polymerase II-associated factor 1 homolog | 6.49 | 44,734 | 131,600 | 88,860 | Regulation of transcription, Wnt signaling pathway ●Alzheimer’s disease/Neuronal degeneration (s87) | Score: 39 Matches: 2(1) Sequences: 2(1) | Q8K2T8 |
16 | 8.11E-04 | 1.4 | Ski oncogene | 6.15 | 88,567 | 83,770 | 115,100 | Signalling, Inhibits TGF beta signalling | Score: 37 Matches: 3(1) Sequences: 1(1) | Q60698 |
9 | 1.70E-02 | 1.6 | 6.82 | 119,868 | 157,100 | 99,730 | Score: 34 Matches: 1(1) Sequences: 1(1) | |||
36 | 4.00E-03 | 1.6 | Histidine--tRNA ligase, cytoplasmic | 6.16 | 55,349 | 88,260 | 144,700 | Protein synthesis ●Alzheimer’s disease/Neuronal degeneration (s88) | Score: 136 Matches: 10(6) Sequences: 9(6) | Q61035 |
7a | 4.00E-03 | 1.4 | Putative helicase Mov10l1 | 6.14 | 123,179 | 29,440 | 42,400 | Negative regulation of cell cycle | Score: 43 Matches: 1(1) Sequences: 1(1) | Q99MV5 |
7b | 6.00E-03 | 1.5 | 6.19 | 121,854 | 32,970 | 49,230 | Score: 43 Matches: 1(1) Sequences: 1(1) | |||
44 | 5.00E-03 | 1.3 | Rab GDP dissociation inhibitor beta | 6.65 | 47,312 | 412,900 | 311,300 | Signalling, Positive regulation of GTPase activity ●Alzheimer’s disease/Neuronal degeneration (s89) | Score: 104 Matches: 9(4) Sequences: 8(4) | Q61598 |
84 | 6.00E-03 | 1.6 | Transcription termination factor 1 | 6.12 | 99,390 | 8292.349 | 13,440 | Regulation of transcription | Score: 36 Matches: 2(1) Sequences: 2(1) | Q62187 |
32 | 7.00E-03 | 1.5 | HMG box-containing protein | 6.12 | 64,083 | 137,800 | 200,000 | Regulation of transcription, Wnt signaling | Score: 40 Matches: 1(1) Sequences: 1(1) | Q8R316 |
118 | 8.00E-03 | 1.4 | UMP-CMP kinase | 6.16 | 22,194 | 133,000 | 187,600 | Pyrimidine biosynthesis | Score: 91 Matches: 6(4) Sequences: 6(4) | Q9DBP5 |
100 | 9.00E-03 | 1.4 | Paraspeckle component 1 | 6.86 | 46,160 | 178,800 | 126,900 | Control of transcription Circadian rhythms | Score: 37 Matches: 3(0) Sequences: 3(0) | Q8R326 |
43 | 1.07E-02 | 1.3 | Ornithine aminotransferase, mitochondrial | 6.42 | 46,949 | 495,800 | 385,200 | Amino acid metabolism ●Mitochondrial | Score: 90 Matches: 7(5) Sequences: 7(5) | P29758 |
61 | 1.10E-02 | 1.2 | Omega-amidase NIT2 | 6.88 | 30,652 | 104,200 | 87,480 | Amino acid metabolism | Score: 45 Matches: 3(1) Sequences: 3(1) | Q9JHW2 |
121 | 1.30E-02 | 1.5 | Cytidine deaminase | 5.63 | 15,212 | 32,230 | 47,840 | Pyrimidine metabolism, Negative regulation of cell growth | Score: 34 Matches: 1(1) Sequences: 1(1) | P56389 |
59 | 1.70E-02 | 1.3 | Haloacid dehalogenase-like hydrolase domain-containing protein 2 | 6.16 | 30,652 | 216,800 | 280,000 | Metabolism, Dephosphorylation | Score: 50 Matches: 5(2) Sequences: 2(1) | Q3UGR5 |
120 | 1.80E-02 | 1.4 | Sec1 family domain-containing protein 1 | 4.66 | 13,958 | 79,910 | 109,000 | Cell morphogenesis, protein transport | Score: 48 Matches: 3(1) Sequences: 1(1) | Q8BRF7 |
103 | 1.80E-02 | 1.3 | Ras-like protein family member 10B | 6.07 | 43,143 | 78,700 | 105,900 | Signaling | Score: 39 Matches: 1(1) Sequences: 1(1) | Q5SSG5 |
5 | 1.90E-02 | 1.5 | Neutral alpha-glucosidase AB | 6.13 | 146,358 | 32,530 | 47,230 | Glycoprotein syntheses, Glycan metabolism | Score: 40 Matches: 3(1) Sequences: 3(1) | Q8BHN3 |
119 | 2.00E-02 | 1.4 | Acylamino-acid-releasing enzyme | 6.99 | 19,848 | 113,700 | 83,510 | Beta amyloid processes, Proteolysis ●Alzheimer’s disease/Neuronal degeneration (s90) | Score: 39 Matches: 5(1) Sequences: 2(1) | Q8R146 |
111 | 2.10E-02 | 1.2 | Phosphatidylinositol transfer protein alpha isoform | 6.68 | 33,206 | 394,200 | 338,000 | Transport of PtdIns and phosphatidylcholine, Axonogenesis | Score: 51 Matches: 11(1) Sequences: 7(1) | P53810 |
83 | 2.20E-02 | 1.3 | Solute carrier family 12 member 1 | 4.62 | 98,323 | 38,480 | 51,740 | Regulation of ionic balance and cell volume | Score: 39 Matches: 3(1) Sequences: 3(1) | P55014 |
14 | 2.30E-02 | 1.2 | RalBP1-associated Eps domain-containing protein 2 | 5.21 | 83,232 | 525,500 | 609,200 | Growth factor signaling, Cell migration | Score: 36 Matches: 1(1) Sequences: 1(1) | Q80XA6 |
115 | 2.40E-02 | 1.3 | Isopentenyl-diphosphate delta-isomerase 2 | 6.13 | 25,465 | 19,710 | 26,100 | Cholesterol metabolism | Score: 39 Matches: 1(1) Sequences: 1(1) | Q8BFZ6 |
102 | 2.50E-02 | 1.2 | Glutamine synthetase | 7.25 | 45,228 | 1,248,000 | 1,016,000 | Positive regulation of synaptic transmission, Cellular response to starvation ●Alzheimer’s disease/Neuronal degeneration (s91) | Score: 160 Matches: 32(9) Sequences: 10(7) | P15105 |
70 | 2.70E-02 | 1.2 | Glycolipid transfer protein | 7.25 | 20,036 | 113,000 | 92,910 | Glycolipid transport, Glucoceramide transport | Score: 36 Matches: 2(1) Sequences: 2(1) | Q9JL62 |
123 | 3.20E-02 | 1.2 | Cystatin-B | 7.14 | 12,833 | 63,610 | 52,090 | Protease inhibitor, Negative regulation of proteolysis ●Alzheimer’s disease/Neuronal degeneration (s92) | Mass: 11153 Score: 45 Matches: 1(1) Sequences: 1(1) | Q62426 |