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Table 2 The risk of cardio-renal outcomes across tertiles of caffeine intakes: Tehran Lipid and Glucose Study

From: Tea, coffee, caffeine intake and the risk of cardio-metabolic outcomes: findings from a population with low coffee and high tea consumption

Caffeine

Tertile 1

Tertile 2

Tertile 3

P for trend

Each 100 mg/d

CVDa

(< 60.25 mg/day)

(60.25–151.4 mg/day)

(> 151.4 mg/day)

 

 Crude

1.00

1.16 (0.63–2.14)

2.02 (1.16–3.50)*

0.007

1.16 (1.03–1.29)

 Model 1

1.00

1.30 (0.69–2.45)

2.26 (1.27–4.02)*

0.003

1.16 (1.03–1.29)

 Model 2

1.00

1.35 (0.71–2.56)

2.22 (1.23–4.01)*

0.005

1.14 (1.01–1.28)*

HTN b

(< 60.60 mg/day)

(60.61–151.3 mg/day)

(> 151.3 mg/day)

  

 Crude

1.00

1.02 (0.75–1.40)

1.21 (0.89–1.64)

0.17

1.11 (1.02–1.22)*

 Model 1

1.00

1.02 (0.73–1.43)

0.98 (0.70–1.36)

0.95

1.03 (0.93–1.14)

 Model 2

1.00

1.02 (0.73–1.44)

0.98 (0.70–1.38)

0.94

1.03 (0.93–1.14)

CKDc

(< 56.16 mg/day)

(56.17–150.2 mg/day)

(> 150.2 mg/day)

 

 Crude

1.00

0.83 (0.62–1.12)

0.87 (0.65–1.17)

0.47

1.03 (0.93–1.14)

 Model 1

1.00

0.81 (0.59–1.12)

0.87 (0.63–1.19)

0.49

1.03 (0.92–1.15)

 Model 2

1.00

0.83 (0.60–1.14)

0.87 (0.63–1.21)

0.52

1.04 (0.93–1.16)

  1. Data are hazard ratio (95% CI); proportional hazard Cox regression and logistic regression were used. CI confidence interval, CKD chronic kidney disease, CVD cardiovascular disease, HTN hypertension
  2. Median of caffeine intake in the first, second and third tertile in CVD population was 78.79, 103.5 and 137.3 mg/day, respectively
  3. Median of caffeine intake in the first, second and third tertile in HTN population was 51.20, 103.3 and 202 mg/day, respectively
  4. Median of caffeine intake in the first, second and third tertile in CKD population was 50.93, 101.2 and 200.5 mg/day, respectively
  5. aModel 1 was adjusted for CVD risk score; model 2 was additionally adjusted for dietary fat (g/d), fiber (g/d) and total energy (kcal/d)
  6. bModel 1 was adjusted for sex, age, BMI, TGs to HDL-C ratio; model 2 was additionally adjusted for total energy intake (kcal/d)
  7. cModel 1 was adjusted for sex, age, BMI, TGs to HDL-C ratio, and smoking; model 2 was additionally adjusted for dietary fat (g/d), fiber (g/d) and total energy (kcal/d)
  8. *P <  0.05