Fig. 10

The proposed mechanism underlying the effects of C8:0 on inhibiting inflammation and reducing the atherosclerotic. Arrows (↓) represent a decreasing level and downregulation of activity or protein or mRNA expression. The“★” indicate the manner in which C8:0 acts on TLR4 or macrophage is unclear. LPS, lipopolysaccharide; TLR4, toll-like receptor 4; MyD88, myeloid differentiation primary response 88; NF-κB, nuclear factor kappa B; TNF-α, tumor necrosis factor alpha; TAK1, TGF-β-activated kinase 1; MAPK, mitogen-activated protein kinase; JNK, c-Jun N-terminal kinase; IKKα, inhibitor kappa B kinase α; IKKβ, inhibitor kappa B kinase β; IL-1β, interleukin-1β; IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein-1; TC, total cholesterol; LDL-C, low density lipoprotein cholesterol