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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: Flavonoids as inducers of white adipose tissue browning and thermogenesis: signalling pathways and molecular triggers

Fig. 2

The signaling pathways and mechanisms whereby flavonoids promote WAT browning. SNS: sympathetic nervous system; β3-AR: β3 adrenocepter; cAMP: cyclic adenosine monophosphate; PKA: protein kinase A; AMPK: adenosine monophosphate-activated protein kinase; AICAR: 5-Amino-4-formamide imidazolium ribonucleotide; Sirt1: silent mating type information regulation 2 homolog 1; VMH: ventromedial hypothalamus; JNK: C-Jun amino-terminal kinase; T4: tetraiodothyronine; T3: triiodothyronine; NAD+: nicotinamide adenine dinucleotide; PGC-1α: proliferator-activated receptor-γ coactivator 1α; PPAR: peroxisome proliferator activated receptor; WAT: white adipose tissue; BAT: brown adipose tissue; PRDM16: positive regulatory domain containing 16; UCP-1: uncoupling protein 1; HSL: hormone sensitive lipase; ACC: acetyl-coenzyme A carboxylase

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Nutrition & Metabolism

ISSN: 1743-7075

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