Fig. 2

CUR treatment mitigates the development of insulin resistance in HFS diet fed mice. At week 16, Control, HFS, and HFS + CUR mice were fasted overnight and an intraperitoneal glucose tolerance test (IPGTT) was performed with1 g/kg of glucose. a Blood glucose levels (mg/dL) following IPGTT and the area under the curve (AUC) analysis. b Short-term (4 h) fasted blood glucose levels (mg/dL) at week 16. During IPGTT, blood samples were collected at each time point and c insulin levels (ng/mL) were measured and AUC calculated. d 4 h fasted insulin levels (ng/mL) at week 16. An insulin tolerance test (ITT) was performed 16 weeks after diet treatment (1 U/kg, i.p.). e The curve depicts the percentage values of initial blood glucose concentration and AUC during ITT. f IDE and GAPDH expression levels in liver tissue lysates on 16 weeks after diet treatment (n = 7) (^*p ≤ 0.05, ^**p ≤ 0.01, ^***p ≤ 0.001, ^****p ≤ 0.0001 compared to Control; ^#p ≤ 0.05, ^##p ≤ 0.01 compared to HFS + CUR)