Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity

Table 1 Mouse Diet Composition (grams/kg)

Ingredient	Control^a	HFS^a	HFS + CUR^a
High Nitogen Casein	200	200	200
L-Cystine	3	3	3
Sucrose	90	90	90
Cornstarch	398.562	100.46	100.46
Dyetrose	132	160	160
Dextrose	0	160	156.1
Soybean oil	70	70	70
tert-Butylhydroquinone	0.014	0.014	0.014
Whole Butter (18% Water)	0	150	150
Ethoxyquin	0.024	0.024	0.024
Lard	0	20	20
Cellulose	50	50	50
Mineral mix #210025	35	35	35
Vitamin mix #310025	10	10	10
Supplement #410750	10	10	10
Choline Chloride	1.4	1.4	1.4
Red-Dye (roughly 31 g of water will evaporate)	0	0.1	0
Curcumin (roughly 31 g of water will evaporate)	0	0	4
Total	1,000	1,000	1,000

ISSN: 1743-7075