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Table 2 Effect of alcohol and GRSs on blood glucose deterioration

From: Alcohol consumption and its interaction with genetic variants are strongly associated with the risk of type 2 diabetes: a prospective cohort study

  Overall Men Women
  OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value
Alcohol 2.24 (1.76, 2.87) <.0001* 1.84 (1.20,2.84) 0.0055 2.47 (1.84, 3.32) 0.0032*
T2D-GRS 1.25 (1.11, 1.42) 0.0004* 1.24 (1.03, 1.51) 0.0269 1.26 (1.07, 1.49) 0.0062
BC-GRS 1.04 (0.99, 1.08) 0.0565 1.05 (0.99, 1.11) 0.1384 1.03 (0.98, 1.08) 0.2151
IR-GRS 1.09 (1.01, 1.17) 0.0308 1.17 (1.04, 1.32) 0.009 1.03 (0.94, 1.14) 0.5164
WHR-GRS 1.14 (1.00, 1.30) 0.0439 1.30 (1.06, 1.60) 0.0113 1.05 (0.88,1.24) 0.6032
BMI-GRS 0.92 (0.81, 1.04) 0.1973 0.95 (0.78, 1.15) 0.5693 0.90 (0.76, 1.07) 0.232
  1. Data are shown as odds ratio and 95% confidence intervals
  2. Covariates: age, sex, smoking, and BMI
  3. P values <0.05 were shown in bold. * indicates significance after Bonferroni correction