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Table 4 Generalized multifactor dimensionality reduction (GMDR) analysis of factors that influence subcutaneous fat deposition at the subscapular site without and with adjusting for covariates

From: Subcutaneous fat mass is associated with genetic risk scores related to proinflammatory cytokine signaling and interact with physical activity in middle-aged obese adults

Model

No adjustment

Adjusted for age, sex, area, BMI

TRBA

TEBA

Sign test (P value)

CVC

TRBA

TEBA

Sign test (P value)

CVC

Model 1: TGFBR3 rs7526590

0.5367

0.5050

6(0.377)

6/10

0.5427

0.5017

7(0.172)

6/10

Model 1 plus IL17A rs4711998

0.5446

0.4964

4(0.828)

2/10

0.5543

0.5457

9(0.011)

9/10

Model 2 plus ADCY2 rs326149

0.5618

0.5063

5(0.623)

3/10

0.5720

0.5223

9(0.011)

5/10

Model 3 plus CYFIP2 rs733730

0.5797

0.5173

9(0.011)

2/10

0.5906

0.5216

8(0.055)

3/10

Model 4 plus ESRRG rs4846514

0.6094

0.5332

9(0.011)

7/10

0.6234

0.5248

7(0.172)

3/10

Model 5 plus TCF7L2 rs7917983

0.6500

0.5267

10(0.001)

6/10

0.6660

0.5302

8(0.055)

5/10

Model 6 plus ZNF766 rs41497444

0.7020

0.5321

10(0.001)

10/10

0.7216

0.5605

10(0.001)

10/10

Model 7 plus IL5RA rs2290610

0.7541

0.5213

8(0.055)

6/10

0.7707

0.5309

8(0.055)

10/10

Model 8 plus CNTN4 rs17024684

0.8008

0.4960

5(0.623)

6/10

0.8147

0.4978

4(0.828)

10/10

Model 9 plus IL5RA rs3792421

0.8343

0.4973

5(0.623)

10/10

0.8462

0.5058

6(0.377)

10/10

  1. TRBA trained balanced accuracy, TEBA test balance accuracy, CVC cross-validation consistency; sign test, result and P value for the significance of GMDR model by sign test with and without adjusting for covariates; BMI body mass index, ESRRG estrogen related receptor gamma, TGFBR3 transforming growth factor beta receptor 3, IL5RA interleukin 5 receptor subunit alpha, CNTN4 contactin 4, ADCY2 adenylate cyclase 2, CYFIP2 cytoplasmic FMR1 interacting protein 2, IL17A interleukin 17A, TCF7L2 transcription factor 7 like 2, ZNF766 zinc finger protein 766
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Nutrition & Metabolism

ISSN: 1743-7075

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