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Table 4 Generalized multifactor dimensionality reduction (GMDR) analysis of factors that influence subcutaneous fat deposition at the subscapular site without and with adjusting for covariates

From: Subcutaneous fat mass is associated with genetic risk scores related to proinflammatory cytokine signaling and interact with physical activity in middle-aged obese adults

ModelNo adjustmentAdjusted for age, sex, area, BMI
TRBATEBASign test (P value)CVCTRBATEBASign test (P value)CVC
Model 1: TGFBR3 rs75265900.53670.50506(0.377)6/100.54270.50177(0.172)6/10
Model 1 plus IL17A rs47119980.54460.49644(0.828)2/100.55430.54579(0.011)9/10
Model 2 plus ADCY2 rs3261490.56180.50635(0.623)3/100.57200.52239(0.011)5/10
Model 3 plus CYFIP2 rs7337300.57970.51739(0.011)2/100.59060.52168(0.055)3/10
Model 4 plus ESRRG rs48465140.60940.53329(0.011)7/100.62340.52487(0.172)3/10
Model 5 plus TCF7L2 rs79179830.65000.526710(0.001)6/100.66600.53028(0.055)5/10
Model 6 plus ZNF766 rs414974440.70200.532110(0.001)10/100.72160.560510(0.001)10/10
Model 7 plus IL5RA rs22906100.75410.52138(0.055)6/100.77070.53098(0.055)10/10
Model 8 plus CNTN4 rs170246840.80080.49605(0.623)6/100.81470.49784(0.828)10/10
Model 9 plus IL5RA rs37924210.83430.49735(0.623)10/100.84620.50586(0.377)10/10
  1. TRBA trained balanced accuracy, TEBA test balance accuracy, CVC cross-validation consistency; sign test, result and P value for the significance of GMDR model by sign test with and without adjusting for covariates; BMI body mass index, ESRRG estrogen related receptor gamma, TGFBR3 transforming growth factor beta receptor 3, IL5RA interleukin 5 receptor subunit alpha, CNTN4 contactin 4, ADCY2 adenylate cyclase 2, CYFIP2 cytoplasmic FMR1 interacting protein 2, IL17A interleukin 17A, TCF7L2 transcription factor 7 like 2, ZNF766 zinc finger protein 766