Skip to main content
Fig. 3 | Nutrition & Metabolism

Fig. 3

From: Curcumin prevents high-fat diet-induced hepatic steatosis in ApoE−/− mice by improving intestinal barrier function and reducing endotoxin and liver TLR4/NF-κB inflammation

Fig. 3

Effects of curcumin on intestinal permeability in HFD-fed ApoE−/− mice. ApoE−/− mice were fed a normal diet, high-fat diet and high-fat diet supplemented with 0.1% curcumin (w/w) for 16 weeks. (a) The protein expression of ZO-1 and occludin in ileal tissues was measured by Western blotting. (Top panel) Representative blot, (Bottom panel) Quantitative analysis of panel A. Results are mean ± SEM (n = 10 per group). ##P < 0.01 versus control group; *P < 0.05, **P < 0.01 versus HF group. (b) Ultrastructural observation of the tight junctions in the ileal mucosa and the width of the tight junction gap (transmission electron microscopy, 4000× or 8000×) (n = 10 per group). (c) The width of the tight junction gap (n = 10 per group). #P < 0.05 versus control group; *P < 0.05 versus HF group. Control, normal diet; HF, high-fat diet; HF + Curcumin, high-fat diet supplemented with curcumin

Back to article page

Nutrition & Metabolism

ISSN: 1743-7075

Contact us