Table 2 Potential target genes of exosomal milk miRNA-148a and predicted regulatory effects
miRNA-148a target genes | Transcription factors and enzymes | Expected regulatory effects | Ref. |
|---|---|---|---|
PRKAA1 | AMP-activated protein kinase, catalytic subunit α 1 | Reduced activity of AMPK resulting in activation of mTORC1 | [66] |
PRKAG2 | AMPK regulatory subunit γ 2 | Reduced activity of AMPK resulting in activation of mTORC1 | |
MAFB | V-MAF musculoaponeurotic fibrosarcoma oncogene family, protein B | Reduced expression of SCL2A2, SCL30A6, CAMK2B, NNAT and MAFA | [101] |
ESRRG | Estrogen-related receptor- γ | Reduced expression of MDH1, COX6A2, ATP2A2, NDUFS2 and ATP6V0A2 | |
PPARGC1A | Peroxisome proliferator-activated receptor- γ, coactivator 1 α (PGC1 α) | Reduced expression of MDH1, COX6A2, ATP2A2, NDUFS2 and ATP6V0A2 | |
DNMT1 | DNA methyltransferase 1 | Reduced repression of ARX | |
PTEN | Phosphatase and tensin homolog | Increased PI3K-AKT-mTORC1 signaling | [66] |
WNT1 | Wingless-type MMTV integration site family, member 1 | Reduced suppression of adipogenesis | [139] |
WNT10B | Wingless-type MMTV integration site family, member 10B | Reduced suppression of adipogenesis | [140] |
CCKBR | Cholecytokinin B receptor | Decreased satiety signaling |