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Table 3 Odds ratio (95% confidence intervals) of GDM associated with different levels of RBP4 in the first trimester and second trimester

From: Plasma retinol-binding protein 4 in the first and second trimester and risk of gestational diabetes mellitus in Chinese women: a nested case-control study

 

Quartiles of RBP4

P for trend

Per 1 log increment

Q1

Q2

Q3

Q4

First trimester

 Median (range)

5.8 (4.2–8.2)

12.9 (11.4–14.0)

20.6 (17.7–22.7)

42.1 (32.5–61.6)

  

 Cases (%)

31 (45.6)

28 (41.8)

34 (50.0)

42 (62.7)

  

 Model 1a

1.00

1.07 (0.44–2.64)

2.06 (0.76–5.58)

3.63 (1.30–10.12)

0.004

3.60 (1.29–10.03)

 Model 2b

1.00

1.06 (0.41–2.71)

2.58 (0.86–7.75)

3.72 (1.27–10.87)

0.005

3.14 (1.09–9.06)

 Model 3c

1.00

1.06 (0.41–2.74)

2.60 (0.86–7.86)

3.71 (1.27–10.84)

0.005

3.12 (1.08–9.04)

Second trimester

 Median (range)

5.9 (4.6–8.9)

13.3 (12.0–14.9)

20.1 (17.8–23.7)

40.2 (30.1–54.9)

  

 Cases (%)

32 (47.8)

27 (39.7)

35 (52.2)

41 (60.3)

  

 Model 1a

1.00

0.89 (0.36–2.17)

2.30 (0.78–6.79)

3.26 (1.09–9.72)

0.018

3.62 (1.17–11.25)

 Model 2b

1.00

0.88 (0.34–2.25)

2.88 (0.88–9.42)

3.25 (1.02–10.34)

0.026

3.34 (1.03–10.85)

 Model 3c

1.00

0.89 (0.35–2.30)

2.95 (0.90–9.69)

3.30 (1.03–10.52)

0.028

3.38 (1.03–11.08)

  1. Abbreviations: GDM Gestational diabetes mellitus, RBP4 Retinol-binding protein 4
  2. a Model 1: adjusted for maternal age, education, occupation, gestational weeks of RBP4 measurements in the first trimester, pre-pregnancy BMI, GWG before OGTT, SBP, DBP
  3. b Model 2: Model 1 additional adjusted total cholesterol, triglyceride, HDL, LDL, GFR, ALT, AST
  4. c Model 3: Model 2 additional adjusted daily intake of calories and weekly physical activity time