High fat-induced inflammation in vascular endothelium can be improved by Abelmoschus esculentus and metformin via increasing the expressions of miR-146a and miR-155

Table 1 Effects of AE and metformin on measured metabolic parameters

Group	BW (g)	FBG (mmol/L)	TC (mmol/L)	TG (mmol/L)	LDL-c (mmol/L)	HDL-c (mmol/L)
NC	608 ± 11.12	3.87 ± 0.5	0.65 ± 0.39	0.70 ± 0.36	1.30 ± 0.39	0.83 ± 0.15
HF	690 ± 12.12^*	5.50 ± 1.55^**	1.18 ± 0.42^**	1.4 ± 0.29^**	1.70 ± 0.34^*	0.52 ± 0.21^*
HF-OA	660 ± 12.94^*	4.5 ± 1.48	0.75 ± 0.18^#	0.45 ± 0.32^##	1.45 ± 0.29	0.72 ± 0.28
HF-OB	668 ± 13.13^*	4.7 ± 0.77	0.85 ± 0.22	0.65 ± 0.17^##	1.20 ± 0.23^##	0.76 ± 0.12
HF-Met	650 ± 8.37^#	4.3 ± 1.04^#	0.80 ± 0.34^#	0.80 ± 0.28^##	0.86 ± 0.19^*##	0.74 ± 0.5

NC normal chow group, HF high fat diet group, HF-OA high fat diet and Abelmoschus esculentus (800 mg/kg) treatment, HF-OB high fat diet and Abelmoschus esculentus (400 mg/kg) treatment, HF-Met high fat diet and metformin (200 mg/kg) treatment, BW body weight, FBG fasting blood glucose, TC total cholesterol, TG total triacylglycerol, LDL-c low density lipoprotein cholesterol, HDL-c high density lipoprotein cholesterol
Data are presented as mean ± SD. ^*P < 0.05 versus NC group. ^**P < 0.01 versus NC group. ^#P<0.05 versus HF group. ^##P<0.01 versus HF group. n = 6–15 per group

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