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Table 3 Relations between Gensini score and circulating metabolites in acute coronary syndrome patients

From: Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study

Variable

Adjusted means (standard errors) of Gesini score across quartiles of metabolites levesl

P for trend

Regression coefficient (95% CI) per 1-SD increment d

1

2

3

4

  

Betaine

 Model 1 a

75.7 (7.68)

75.0 (8.33)

73.7 (7.75)

71.1 (6.37)

0.57

-0.18 (-6.12~5.75)

 Model 2 b

71.8 (13.7)

72.0 (13.5)

68.9 (14.0)

68.4(12.9)

0.65

0.11 (-5.82~6.04)

 Model 3 c

71.8 (13.7)

72.0 (13.6)

68.9 (14.0)

68.4 (12.9)

0.65

0.11 (-5.84~6.06)

Choline

 Model 1 a

71.6 (9.44)

73.1 (10.34)

62.4 (10.42)

75.7 (5.29)

0.50

4.32 (-2.03~10.66)

 Model 2 b

69.8 (14.6)

72.0 (14.4)

54.8 (15.7)

71.5 (12.5)

0.68

3.77 (-2.63~10.16)

 Model 3 c

69.8 (14.7)

72.0 (14.4)

54.8 (15.7)

71.5 (12.6)

0.68

3.77 (-2.64~10.19)

TMA

 Model 1 a

77.0 (7.44)

77.8 (8.20)

72.7 (7.57)

69.3 (6.63)

0.30

-3.78 (-10.08~2.52)

 Model 2 b

78.2 (13.7)

74.8 (13.8)

72.9 (13.6)

63.6 (12.8)

0.11

-5.40 (-11.85~1.06)

 Model 3 c

78.3 (13.7)

74.7 (13.8)

72.8 (13.7)

63.5 (12.9)

0.11

-5.56 (-12.13~1.00)

TMAO

 Model 1 a

73.0 (6.47)

79.0 (7.59)

66.8 (8.68)

73.4 (7.36)

0.80

-1.28 (-7.84~5.27)

 Model 2 b

67.3 (13.4)

76.0 (13.3)

62.5 (14.5)

68.9 (14.5)

0.92

-1.17 (-7.84~5.51)

 Model 3 c

67.5 (13.5)

76.2 (13.4)

62.6 (14.6)

68.8 (13.0)

0.92

-1.29 (-8.33~5.75)

Metabolite Score

 Model 1 a

76.7 (9.82)

63.0 (9.01)

73.4 (7.46)

76.2 (5.87)

0.55

3.14 (-7.23~13.51)

 Model 2 b

75.4 (14.8)

61.5 (14.2)

68.4 (13.4)

73.5 (12.7)

0.64

2.46 (-7.93~12.85)

 Model 3 c

75.3 (14.8)

61.3 (14.3)

68.4 (13.5)

73.5 (12.7)

0.64

2.49 (-7.99~12.96)

Ratio of betaine/choline

 Model 1 a

76.2 (5.33)

71.1 (8.55)

79.7 (11.19)

58.4 (9.83)

0.15

-4.9 (-11.21~1.41)

 Model 2 b

73.7 (13.0)

68.7 (13.3)

78.9 (15.6)

58.4 (15.0)

0.26

-4.15 (-10.55~2.25)

 Model 3 c

73.7 (13.0)

68.5 (13.4)

78.8 (15.7)

58.4 (15.0)

0.26

-4.15 (-10.56~2.26)

  1. Inverse normal transformation was applied to raw values of metabolites. To build the score, we applied a weighted sum of concentrations of 4 metabolites in the choline pathway (betaine, choline, TMA and TMAO). The ratio of betaine/choline was calculated by dividing the raw values and then applying inverse normal transformations
  2. TMA, trimethylamine; TMAO, trimethylamine N-oxide
  3. a Model 1 was adjusted for age, sex, smoking index and body mass index
  4. b Model 2 was adjusted for all factors in model 1, plus history of disease (i.e., hypertension, diabetes mellitus and hyperlipidemia)
  5. c Model 3 was adjusted for all factors in model 2, plus kidney function measured by eGFR
  6. d The regression coefficient represented the average difference in the Gensini score per 1-SD increase in the transformed levels of metabolites
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Nutrition & Metabolism

ISSN: 1743-7075

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