Variables | WD (n = 15) | CRD (n = 15) | MRD (n = 15) | p-value2) (W-M-C) | p-value3) (W-M) | p-value4) (W-C) | p-value5) (M-C) |
---|---|---|---|---|---|---|---|
Pb | |||||||
 Baseline | 4.6(3.2–7.6) | 5.7(3.4–9.3) | 4.3(3.4–6.6) |  |  |  |  |
 4-week | 3.3(2.6–4.9) | 5.6(3.1–9.6) | 3.6(2.9–6.8) | 0.668 | 0.443 | 0.819 | 0.547 |
p-value1) | 0.080 | 0.454 | 0.178 | Â | Â | Â | Â |
Ni | |||||||
 Baseline | 0.9(0.7–1.4) | 1.0(0.3–1.3) | 0.9(0.5–1.2) |  |  |  |  |
 4-week | 0.6(0.4–1.0) | 0.6(0.5–1.3) | 1.0(0.6–1.5) | 0.063 | 0.228 | 0.025 | 0.212 |
p-value | 0.003 | 0.254 | 0.600 | Â | Â | Â | Â |
Rh | |||||||
 Baseline | 0.0004(0.0002–0.0006) | 0.0004(0.0003–0.0007) | 0.0004(0.0002–0.0004) |  |  |  |  |
 4-week | 0.0002(0.0–0.0004) | 0.0004(0.0002–0.0007) | 0.0003(0.0002–0.0004) | 0.067 | 0.034 | 0.070 | 0.770 |
p-value | 0.005 | 0.748 | 0.578 | Â | Â | Â | Â |
Be | |||||||
 Baseline | 0.0037(0.0032–0.0058) | 0.0042(0.0024–0.0068) | 0.0041(0.0020–0.0062) |  |  |  |  |
 4-week | 0.0029(0.0025–0.0038) | 0.0034(0.0024–0.0096) | 0.0055(0.0019–0.0099) | 0.292 | 0.431 | 0.097 | 0.648 |
p-value | 0.147 | 0.627 | 0.235 | Â | Â | Â | Â |
As | |||||||
 Baseline | 0.22(0.15–0.37) | 0.23(0.15–0.31) | 0.18(0.14–0.29) |  |  |  |  |
 4-week | 0.20(0.15–0.28) | 0.19(0.15–0.25) | 0.20(0.13–0.28) | 0.534 | 0.480 | 0.468 | 0.361 |
p-value | 0.262 | 0.041 | 0.989 | Â | Â | Â | Â |
Hg | |||||||
 Baseline | 7.17(5.21–11.63) | 6.56(4.36–8.91) | 9.06(6.91–14.99) |  |  |  |  |
 4-week | 8.37(5.95–10.51) | 6.89(4.52–9.71) | 10.05(7.38–15.72) | 0.585 | 0.934 | 0.455 | 0.320 |
p-value | 0.639 | 0.229 | 0.107 | Â | Â | Â | Â |
U | |||||||
 Baseline | 0.22(0.07–0.37) | 0.18(0.03–0.61) | 0.14(0.01–1.52) |  |  |  |  |
 4-week | 0.12(0.04–0.35) | 0.18(0.03–0.43) | 0.10(0.02–1.81) | 0.596 | 0.329 | 0.520 | 0.771 |
p-value | 0.098 | 0.734 | 0.798 | Â | Â | Â | Â |
Sn | |||||||
 Baseline | 0.61(0.29–2.35) | 0.38(0.30–0.77) | 0.53(0.40–1.21) |  |  |  |  |
 4-week | 0.55(0.35–0.95) | 0.44(0.28–1.07) | 0.59(0.33–1.98) | 0.090 | 0.050 | 0.068 | 0.852 |
p-value | 0.073 | 0.561 | 0.421 | Â | Â | Â | Â |
Cd | |||||||
 Baseline | 0.03(0.02–0.06) | 0.03(0.02–0.04) | 0.03(0.02–0.05) |  |  |  |  |
 4-week | 0.04(0.03–0.06) | 0.03(0.02–0.05) | 0.03(0.02–0.05) | 0. 774 | > 0.999 | 0.551 | 0.550 |
p-value | 0.482 | 0.394 | 0.871 | Â | Â | Â | Â |
Tl | |||||||
 Baseline | 0.0024(0.0014–0.0052) | 0.0045(0.0031–0.0070) | 0.0025(0.0014–0.0045) |  |  |  |  |
 4-week | 0.0024(0.0020–0.0059) | 0.0053(0.0020–0.0065) | 0.0041(0.0020–0.0051) | 0.032 | 0.221 | 0.206 | 0.008 |
p-value | 0.610 | 0.223 | 0.031 | Â | Â | Â | Â |
Th | |||||||
 Baseline | 0.0034(0.0022–0.0046) | 0.0026(0.0014–0.0038) | 0.0026(0.0020–0.0034) |  |  |  |  |
 4-week | 0.0032(0.0023–0.0039) | 0.0030(0.0016–0.0040) | 0.0025(0.0019–0.0031) | 0.589 | 0.254 | 0.709 | 0.740 |
p-value | 0.945 | 0.323 | 0.820 | Â | Â | Â | Â |
Pd | |||||||
 Baseline | 0.013(0.008–0.024) | 0.009(0.007–0.017) | 0.024(0.006–0.033) |  |  |  |  |
 4-week | 0.014(0.007–0.016) | 0.011(0.007–0.017) | 0.016(0.011–0.032) | 0.583 | 0.290 | 0.547 | 0.819 |
p-value | 0.104 | > 0.999 | 0.703 |  |  |  |  |
Gd | |||||||
 Baseline | 0.002(0.002–0.003) | 0.002(0.001–0.002) | 0.002(0.002–0.003) |  |  |  |  |
 4-week | 0.002(0.001–0.003) | 0.002(0.001–0.003) | 0.002(0.001–0.004) | 0.534 | 0.362 | 0.330 | > 0.999 |
p-value | 0.139 | > 0.999 | 0.945 |  |  |  |  |
Ga | |||||||
 Baseline | 0.016(0.010–0.021) | 0.012(0.006–0.019) | 0.012(0.009–0.016) |  |  |  |  |
 4-week | 0.010(0.008–0.016) | 0.010(0.065–0.014) | 0.013(0.011–0.027) | 0.042 | 0.213 | 0.014 | 0.198 |
p-value | 0.064 | 0.804 | 0.135 | Â | Â | Â | Â |
Au | |||||||
 Baseline | 0.0(0.0–0.1) | 0.1(0.0–0.3) | 0.1(0.0–0.2) |  |  |  |  |
 4-week | 0.1(0.0–0.2) | 0.1(0.0–0.1) | 0.1(0.0–0.3) | 0.669 | 0.490 | 0.907 | 0.438 |
p-value | 0.313 | 0.883 | 0.234 | Â | Â | Â | Â |
Rb | |||||||
 Baseline | 0.229(0.152–1.219) | 0.430(0.187–0.662) | 0.294(0.155–0.422) |  |  |  |  |
 4-week | 0.350(0.145–0.978) | 0.126(0.159–0.563) | 0.161(0.133–0.276) | 0.825 | 0.619 | 0.619 | 0.836 |
p-value | 0.847 | 0.277 | 0.229 | Â | Â | Â | Â |
Ba | |||||||
 Baseline | 11.03(4.55–29.45) | 8.25(5.29–10.76) | 20.61(9.82–32.33) |  |  |  |  |
 4-week | 9.74(5.51–21.31) | 8.67(6.35–15.88) | 16.45(12.56–24.63) | 0.589 | 0.740 | 0.534 | 0.320 |
p-value | 0.847 | 0.934 | 0.208 | Â | Â | Â | Â |
Pt | |||||||
 Baseline | 0.001(0.0–0.001) | 0.001(0.0–0.001) | 0.001(0.0–0.01) |  |  |  |  |
 4-week | 0.0(0.0–0.001) | 0.0(0.0–0.001) | 0.0(0.0–0.001) | 0.777 | 0.509 | 0.891 | 0.616 |
p-value | 0.531 | > 0.999 | > 0.999 |  |  |  |  |
Bi | |||||||
 Baseline | 0.027(0.012–0.131) | 0.014(0.008–0.045) | 0.020(0.007–0.108) |  |  |  |  |
 4-week | 0.038(0.020–0.050) | 0.023(0.011–0.036) | 0.022(0.007–0.054) | 0.690 | 0.384 | 0.575 | > 0.999 |
p-value | 0.248 | 0.891 | > 0.999 |  |  |  |  |
Ce | |||||||
 Baseline | 0.025(0.016–0.074) | 0.021(0.013–0.033) | 0.017(0.010–0.022) |  |  |  |  |
 4-week | 0.028(0.020–0.081) | 0.020(0.013–0.036) | 0.017(0.012–0.050) | 0.899 | 0.772 | 0.648 | > 0.999 |
p-value | 0.463 | 0.534 | 0.552 | Â | Â | Â | Â |
Cs | |||||||
 Baseline | 0.0(0.0–0.01) | 0.0(0.0–0.01) | 0.0(0.0–0.0) |  |  |  |  |
 4-week | 0.0(0.0–0.01) | 0.0(0.0–0.0) | 0.0(0.0–0.0) | 0.213 | 0.173 | 0.976 | 0.115 |
p-value | 0.625 | 0.625 | 0.500 | Â | Â | Â | Â |
Sb | |||||||
 Baseline | 0.083(0.063–0.162) | 0.067(0.059–0.086) | 0.069(0.042–0.087) |  |  |  |  |
 4-week | 0.087(0.066–0.164) | 0.083(0.069–0.089) | 0.073(0.050–0.106) | 0.900 | 0.576 | 0.934 | 0.934 |
p-value | 0.352 | 0.208 | 0.352 | Â | Â | Â | Â |
Al | |||||||
 Baseline | 26.2(18.9–52.8) | 33.2(26.9–36.7) | 27.6(23.3–39.3) |  |  |  |  |
 4-week | 29.4(19.4–55.3) | 37.1(28.8–44.5) | 28.3(19.7–50.4) | 0.809 | 0.648 | 0.534 | > 0.999 |
p-value | 0.934 | 0.463 | 0.367 | Â | Â | Â | Â |
Ag | |||||||
 Baseline | 0.30(0.22–1.18) | 0.85(0.24–1.67) | 0.30(0.14–0.90) |  |  |  |  |
 4-week | 0.24(0.18–1.42) | 0.94(0.28–1.82) | 0.32(0.15–0.88) | 0.218 | 0.191 | 0.097 | 0.836 |
p-value | 0.092 | 0.561 | 0.552 | Â | Â | Â | Â |
In | |||||||
 Baseline | 0.0(0.0–0.0) | 0.0(0.0–0.0) | 0.0(0.0–0.0) |  |  |  |  |
 4-week | 0.0(0.0–0.0) | 0.0(0.0–0.0) | 0.0(0.0–0.0) | 0.398 | > 0.999 | 0.351 | 0.351 |
p-value | – | – | – |  |  |  |  |
Zr | |||||||
 Baseline | 0.14(0.10–0.19) | 0.13(0.08–0.24) | 0.10(0.08–0.15) |  |  |  |  |
 4-week | 0.10(0.06–0.20) | 0.10(0.08–0.19) | 0.08(0.06–0.11) | 0.670 | 0.560 | 0.724 | 0.418 |
p-value | 0.382 | 0.717 | 0.133 | Â | Â | Â | Â |
W | |||||||
 Baseline | 0.025(0.013–0.030) | 0.025(0.010–0.046) | 0.021(0.012–0.036) |  |  |  |  |
 4-week | 0.014(0.008–0.019) | 0.008(0.007–0.014) | 0.015(0.010–0.021) | 0.217 | 0.633 | 0.158 | 0.135 |
p-value | 0.002 | 0.015 | 0.337 | Â | Â | Â | Â |
Te | |||||||
 Baseline | 0.002(0.001–0.005) | 0.003(0.002–0.005) | 0.0(0.0–0.001) |  |  |  |  |
 4-week | 0.002(0.0–0.003) | 0.002(0.0–0.005) | 0.001(0.0–0.002) | 0.270 | 0.754 | 0.134 | 0.228 |
p-value | 0.173 | 0.315 | 0.652 | Â | Â | Â | Â |
Ti | |||||||
 Baseline | 18.2(9.0–63.1) | 17.7(10.5–55.2) | 18.6(13.7–42.0) |  |  |  |  |
 4-week | 19.3(8.8–56.0) | 20.9(11.7–29.5) | 19.9(13.6–30.8) | 0.999 | > 0.999 | 0.901 | 0.984 |
p-value | 0.793 | 0.858 | 0.571 | Â | Â | Â | Â |