Fig. 1
From: The impact of ATP-binding cassette transporters on metabolic diseases
Mechanism of ABC importers. SBP binding to a substrate leads to NBD binding to ATP and a large-scale closing motion. The motion makes TMDs switch to the outward-facing state. The subsequent hydrolysis of ATP leads to the substrate crossing the lipid bilayer, and phosphate release initiates the return of the transporter to its initial state. Abbreviations: ABC, adenosine triphosphate-binding cassette; SBP, substrate-binding protein; NBD, nucleotide-binding domain; TMD, transmembrane domain