The impact of ATP-binding cassette transporters on metabolic diseases

Nutrition & Metabolism

Table 2 Drugs to mediate ABC transporters

Drug	Target	Effect	Mechanism	Source	Reference
Statins	ABCA1	Reduce	↓PI3-K/Akt/FOXO1 & ↓TLR4/ NF-κB	Synthetic	Chen WM et al., 2016 [12]
Triptolide	ABCA1	Induce	↑LPS/TLR4/GPS2	Natural	Chen J et al., 2014 [41]
Cilostazol	ABCA1	Induce	↑LXR/ABCA1/SREBP-1	Synthetic	Jeon BH et al., 2015 [94]
H₂S	ABCA1	Induce	↑PI3-K/Akt/ PPARα	Synthetic	Li D et al., 2016 [95]
Paeonol	ABCA1	Induce	↓Calpain-related pathway	Natural	Li X et al., 2015 [96]
Dgn	ABCA1	Induce	↓miR-19b expression	Natural	Lv YC et al., 2015 [67]
Hydrogen	ABCA1	Induce		Synthetic	Song G et al., 2015 [97]
Metformin	ABCG5& ABCG8	Induce	↑Ldlr ↑AMPK ↓ACLY	Synthetic	Molusky MM et al., 2018 [98]
CoQ10	ABCG1	Induce	↑Activator protein-1/miR-378/ABCG1	Natural	Wang D et al., 2014 [99]
Progesterone	ABCA2	Induce	↑mRNA expression	Synthetic& Natural	Davis W et al., 2018 [47]

Abbreviations: ABC adenosine triphosphate-binding cassette; PI3-K phosphatidylinositol 3-kinase; Akt protein kinase B; FOXO1 forkhead box protein O1; TLR4 Toll-like receptor 4; LPS lipopolysaccharides; GPS2 G protein pathway suppressor 2; LXR liver X receptor; SREBP-1 sterol regulatory element binding protein 1; miR microRNA; H₂S hydrogen sulfide; PPARα peroxisome proliferator-activated receptor α; Dgn Diosgenin; Ldlr low density lipoprotein receptor; AMPK AMP-activated protein kinase; ACLY ATP citrate lyase; CoQ10 Coenzyme Q10

ISSN: 1743-7075