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Table 4 Correlation between Klotho protein and FGF23 protein, TGF-β protein, caspase-3 protein, c-fos and BDNF gene expression (n = 3 and technical replication is 3)

From: High-protein and low-calorie diets improved the anti-aging Klotho protein in the rats’ brain: the toxic role of high-fat diet

Correlation measured factors (Pearson coefficients correlation)

FGF23

TGF-β

Caspase-3

c-fos gene expression

BDNF gene expression

Klotho

 Hippocampus

  r = 0.81

r = 0.65

r = 0.83

r = 0.81

r = 0.64

  P = 0.000

P = 0.003

P = 0.001

P = 0.000

P = 0.000

 Prefrontal cortex

  r = 0.63

r = 0.64

r = 0.80

r = 0.80

r = 0.66

  P = 0.000

P = 0.001

P = 0.001

P = 0.000

P = 0.000

  1. P value less than 0.05 considered significant