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Table 4 Comparison of the genotypes and serum lipid levels in the Han and Maonan populations

From: Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

Genotype n TC (mmol/L) TG (mmol/L) HDL-C (mmol/L) LDL-C (mmol/L) ApoA1 (g/L) ApoB (g/L) ApoA1 /ApoB
SLC44A4 rs577272
 Han
  AA 394 4.75 ± 1.02 0.98(0.76) 1.71 ± 0.45 2.70 ± 0.93 1.43 ± 0.27 0.84 ± 0.24 1.81 ± 0.50
  AG + GG 860 4.86 ± 0.98 1.06 (0.83) 1.73 ± 0.57 2.74 ± 0.84 1.44 ± 0.29 0.83 ± 0.20 1.83 ± 0.62
  F   5.650 − 0.601 1.527 2.674 1.320 1.482 2.873
  P   0.077 0.448 0.539 0.449 0.779 0.728 0.424
 Han/Male
  AA 117 4.95 ± 0.99 0.99 (0.83) 1.64 ± 0.43 2.78 ± 0.85 1.38 ± 0.22 0.80 ± 0.23 1.82 ± 0.51
  AG + GG 442 5.15 ± 1.06 1.11 (0.78) 1.75 ± 0.53 2.92 ± 0.82 1.40 ± 0.26 0.80 ± 0.20 1.84 ± 0.61
  F   6.946 − 2.104 3.295 4.049 1.618 0.936 1.347
  P   0.047 0.035 0.311 0.123 0.632 0.955 0.768
 Han/Female
  AA 277 4.56 ± 1.15 0.92 (0.68) 1.84 ± 0.45 2.61 ± 0.96 1.53 ± 0.29 0.91 ± 0.26 1.83 ± 0.50
  AG + GG 418 4.78 ± 1.01 1.04 (0.82) 1.69 ± 0.61 2.70 ± 0.83 1.49 ± 0.32 0.90 ± 0.28 1.80 ± 0.63
  F   7.633 − 1.991 8.117 3.884 7.189 0.980 3.669
  P   0.018 0.046 0.011 0.200 0.032 0.856 0.231
 Maonan
  AA 309 4.80 ± 1.12 1.09 (0.78) 1.63 ± 0.56 2.83 ± 0.88 1.35 ± 0.27 0.86 ± 0.25 1.69 ± 0.53
  AG + GG 904 5.03 ± 1.01 1.11 (0.89) 1.50 ± 0.45 2.85 ± 0.79 1.38 ± 0.31 0.90 ± 0.22 1.67 ± 0.66
  F   7.760 − 0.274 7.746 1.515 2.958 3.173 1.525
  P   0.012 0.784 0.015 0.682 0.381 0.318 0.679
 Maonan/Male
  AA 46 4.70 ± 0.94 0.97 (0.57) 1.65 ± 0.41 2.72 ± 0.82 1.37 ± 0.30 0.85 ± 0.17 1.69 ± 0.46
  AG + GG 419 4.94 ± 0.83 1.07 (0.76) 1.56 ± 0.43 2.80 ± 0.75 1.37 ± 0.37 0.87 ± 0.21 1.66 ± 0.65
  F   8.088 − 1.032 3.800 3.569 0.925 1.506 3.862
  P   0.004 0.302 0.205 0.256 0.963 0.553 0.226
 Maonan/Female
  AA 263 4.87 ± 1.04 1.15 (0.90) 1.59 ± 0.68 2.89 ± 0.85 1.34 ± 0.25 0.87 ± 0.25 1.69 ± 0.50
  AG + GG 485 5.08 ± 1.12 1.27 (1.04) 1.45 ± 0.72 2.95 ± 0.92 1.39 ± 0.24 0.92 ± 0.23 1.69 ± 0.64
  F   7.717 − 1.159 7.901 3.085 7.246 6.432 0.945
  P   0.015 0.246 0.013 0.352 0.030 0.055 0.923
NOTCH4 rs3134931
 Han
  GG 315 4.80 ± 1.05 0.86 (0.82) 1.77 ± 0.58 2.63 ± 0.86 1.47 ± 0.33 0.81 ± 0.21 1.83 ± 0.62
  AG + AA 939 4.83 ± 1.07 1.26 (0.88) 1.71 ± 0.52 2.73 ± 0.87 1.42 ± 0.27 0.84 ± 0.21 1.79 ± 0.57
  F   1.548 − 7.020 4.333 5.731 1.747 1.536 3.026
  P   0.524 0.000 0.114 0.074 0.481 0.532 0.341
 Han/Male
  GG 163 4.89 ± 0.97 0.80 (0.79) 1.71 ± 0.69 2.75 ± 0.86 1.35 ± 0.29 0.78 ± 0.21 1.81 ± 0.52
  AG + AA 396 5.04 ± 1.04 1.10 (0.85) 1.54 ± 0.41 2.82 ± 0.79 1.39 ± 0.23 0.81 ± 0.21 1.83 ± 0.45
  F   4.416 − 3.528 7.696 3.123 1.416 3.924 1.458
  P   0.109 0.017 0.014 0.323 0.731 0.180 0.557
 Han/Female
  GG 152 4.68 ± 1.12 0.98 (0.79) 1.83 ± 0.45 2.62 ± 0.90 1.60 ± 0.31 0.83 ± 0.22 1.90 ± 0.45
  AG + AA 543 4.68 ± 1.06 1.30 (0.85) 1.87 ± 0.58 2.67 ± 0.88 1.48 ± 0.30 0.89 ± 0.21 1.73 ± 0.56
  F   0.836 − 4.038 2.989 1.612 5.576 2.726 2.874
  P   0.992 0.008 0.404 0.526 0.089 0.432 0.388
 Maonan
  GG 352 4.90 ± 0.91 0.99 (0.86) 1.57 ± 0.43 2.76 ± 0.80 1.39 ± 0.25 0.84 ± 0.20 1.71 ± 0.48
  AG + AA 861 5.03 ± 1.01 1.34 (0.84) 1.55 ± 0.50 2.92 ± 0.86 1.36 ± 0.31 0.90 ± 0.24 1.65 ± 0.57
  F   7.035 − 4.444 1.097 7.241 3.914 2.676 1.422
  P   0.041 0.000 0.815 0.022 0.186 0.443 0.742
 Maonan/Male
  GG 78 4.82 ± 1.02 0.94 (0.73) 1.65 ± 0.45 2.59 ± 0.79 1.39 ± 0.27 0.83 ± 0.25 1.72 ± 0.45
  AG + AA 387 4.93 ± 1.05 1.23 ± 0.81 1.62 ± 0.37 2.80 ± 0.83 1.37 ± 0.38 0.86 ± 0.34 1.70 ± 0.47
  F   5.128 − 3.872 3.968 7.463 1.506 1.578 1.433
  P   0.088 0.012 0.167 0.016 0.543 0.528 0.634
 Maonan/Female
  GG 274 5.04 ± 1.11 1.05 (0.70) 1.52 ± 0.43 2.81 ± 0.72 1.39 ± 0.33 0.85 ± 0.23 1.70 ± 0.45
  AG + AA 474 5.12 ± 1.20 1.40 (0.80) 1.40 ± 0.52 3.04 ± 0.80 1.36 ± 0.29 0.92 ± 0.30 1.63 ± 0.43
  F   4.003 − 4.569 7.087 7.982 3.756 2.973 2.823
  P   0.125 0.000 0.017 0.008 0.195 0.358 0.427
  1. The value of triglyceride was presented as median (interquartile range) for not meet the normal distribution, the difference among the genotypes was determined by the Kruskal–Wallis test. The P value calculated by ANCOVA, using general linear models, and adjusted for age, sex, BMI, smoking status, alcohol use, glucose and hypertension, P < 0.025 was considered statistically significant (corresponding to P < 0.05 after adjusting for 2 independent tests by the Bonferroni correction). n = sample size
  2. TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, ApoA1/ApoB the ratio of apolipoprotein A1 to apolipoprotein B