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Table 4 Comparison of the genotypes and serum lipid levels in the Han and Maonan populations

From: Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

Genotype

n

TC (mmol/L)

TG (mmol/L)

HDL-C (mmol/L)

LDL-C (mmol/L)

ApoA1 (g/L)

ApoB (g/L)

ApoA1 /ApoB

SLC44A4 rs577272

 Han

  AA

394

4.75 ± 1.02

0.98(0.76)

1.71 ± 0.45

2.70 ± 0.93

1.43 ± 0.27

0.84 ± 0.24

1.81 ± 0.50

  AG + GG

860

4.86 ± 0.98

1.06 (0.83)

1.73 ± 0.57

2.74 ± 0.84

1.44 ± 0.29

0.83 ± 0.20

1.83 ± 0.62

  F

 

5.650

− 0.601

1.527

2.674

1.320

1.482

2.873

  P

 

0.077

0.448

0.539

0.449

0.779

0.728

0.424

 Han/Male

  AA

117

4.95 ± 0.99

0.99 (0.83)

1.64 ± 0.43

2.78 ± 0.85

1.38 ± 0.22

0.80 ± 0.23

1.82 ± 0.51

  AG + GG

442

5.15 ± 1.06

1.11 (0.78)

1.75 ± 0.53

2.92 ± 0.82

1.40 ± 0.26

0.80 ± 0.20

1.84 ± 0.61

  F

 

6.946

− 2.104

3.295

4.049

1.618

0.936

1.347

  P

 

0.047

0.035

0.311

0.123

0.632

0.955

0.768

 Han/Female

  AA

277

4.56 ± 1.15

0.92 (0.68)

1.84 ± 0.45

2.61 ± 0.96

1.53 ± 0.29

0.91 ± 0.26

1.83 ± 0.50

  AG + GG

418

4.78 ± 1.01

1.04 (0.82)

1.69 ± 0.61

2.70 ± 0.83

1.49 ± 0.32

0.90 ± 0.28

1.80 ± 0.63

  F

 

7.633

− 1.991

8.117

3.884

7.189

0.980

3.669

  P

 

0.018

0.046

0.011

0.200

0.032

0.856

0.231

 Maonan

  AA

309

4.80 ± 1.12

1.09 (0.78)

1.63 ± 0.56

2.83 ± 0.88

1.35 ± 0.27

0.86 ± 0.25

1.69 ± 0.53

  AG + GG

904

5.03 ± 1.01

1.11 (0.89)

1.50 ± 0.45

2.85 ± 0.79

1.38 ± 0.31

0.90 ± 0.22

1.67 ± 0.66

  F

 

7.760

− 0.274

7.746

1.515

2.958

3.173

1.525

  P

 

0.012

0.784

0.015

0.682

0.381

0.318

0.679

 Maonan/Male

  AA

46

4.70 ± 0.94

0.97 (0.57)

1.65 ± 0.41

2.72 ± 0.82

1.37 ± 0.30

0.85 ± 0.17

1.69 ± 0.46

  AG + GG

419

4.94 ± 0.83

1.07 (0.76)

1.56 ± 0.43

2.80 ± 0.75

1.37 ± 0.37

0.87 ± 0.21

1.66 ± 0.65

  F

 

8.088

− 1.032

3.800

3.569

0.925

1.506

3.862

  P

 

0.004

0.302

0.205

0.256

0.963

0.553

0.226

 Maonan/Female

  AA

263

4.87 ± 1.04

1.15 (0.90)

1.59 ± 0.68

2.89 ± 0.85

1.34 ± 0.25

0.87 ± 0.25

1.69 ± 0.50

  AG + GG

485

5.08 ± 1.12

1.27 (1.04)

1.45 ± 0.72

2.95 ± 0.92

1.39 ± 0.24

0.92 ± 0.23

1.69 ± 0.64

  F

 

7.717

− 1.159

7.901

3.085

7.246

6.432

0.945

  P

 

0.015

0.246

0.013

0.352

0.030

0.055

0.923

NOTCH4 rs3134931

 Han

  GG

315

4.80 ± 1.05

0.86 (0.82)

1.77 ± 0.58

2.63 ± 0.86

1.47 ± 0.33

0.81 ± 0.21

1.83 ± 0.62

  AG + AA

939

4.83 ± 1.07

1.26 (0.88)

1.71 ± 0.52

2.73 ± 0.87

1.42 ± 0.27

0.84 ± 0.21

1.79 ± 0.57

  F

 

1.548

− 7.020

4.333

5.731

1.747

1.536

3.026

  P

 

0.524

0.000

0.114

0.074

0.481

0.532

0.341

 Han/Male

  GG

163

4.89 ± 0.97

0.80 (0.79)

1.71 ± 0.69

2.75 ± 0.86

1.35 ± 0.29

0.78 ± 0.21

1.81 ± 0.52

  AG + AA

396

5.04 ± 1.04

1.10 (0.85)

1.54 ± 0.41

2.82 ± 0.79

1.39 ± 0.23

0.81 ± 0.21

1.83 ± 0.45

  F

 

4.416

− 3.528

7.696

3.123

1.416

3.924

1.458

  P

 

0.109

0.017

0.014

0.323

0.731

0.180

0.557

 Han/Female

  GG

152

4.68 ± 1.12

0.98 (0.79)

1.83 ± 0.45

2.62 ± 0.90

1.60 ± 0.31

0.83 ± 0.22

1.90 ± 0.45

  AG + AA

543

4.68 ± 1.06

1.30 (0.85)

1.87 ± 0.58

2.67 ± 0.88

1.48 ± 0.30

0.89 ± 0.21

1.73 ± 0.56

  F

 

0.836

− 4.038

2.989

1.612

5.576

2.726

2.874

  P

 

0.992

0.008

0.404

0.526

0.089

0.432

0.388

 Maonan

  GG

352

4.90 ± 0.91

0.99 (0.86)

1.57 ± 0.43

2.76 ± 0.80

1.39 ± 0.25

0.84 ± 0.20

1.71 ± 0.48

  AG + AA

861

5.03 ± 1.01

1.34 (0.84)

1.55 ± 0.50

2.92 ± 0.86

1.36 ± 0.31

0.90 ± 0.24

1.65 ± 0.57

  F

 

7.035

− 4.444

1.097

7.241

3.914

2.676

1.422

  P

 

0.041

0.000

0.815

0.022

0.186

0.443

0.742

 Maonan/Male

  GG

78

4.82 ± 1.02

0.94 (0.73)

1.65 ± 0.45

2.59 ± 0.79

1.39 ± 0.27

0.83 ± 0.25

1.72 ± 0.45

  AG + AA

387

4.93 ± 1.05

1.23 ± 0.81

1.62 ± 0.37

2.80 ± 0.83

1.37 ± 0.38

0.86 ± 0.34

1.70 ± 0.47

  F

 

5.128

− 3.872

3.968

7.463

1.506

1.578

1.433

  P

 

0.088

0.012

0.167

0.016

0.543

0.528

0.634

 Maonan/Female

  GG

274

5.04 ± 1.11

1.05 (0.70)

1.52 ± 0.43

2.81 ± 0.72

1.39 ± 0.33

0.85 ± 0.23

1.70 ± 0.45

  AG + AA

474

5.12 ± 1.20

1.40 (0.80)

1.40 ± 0.52

3.04 ± 0.80

1.36 ± 0.29

0.92 ± 0.30

1.63 ± 0.43

  F

 

4.003

− 4.569

7.087

7.982

3.756

2.973

2.823

  P

 

0.125

0.000

0.017

0.008

0.195

0.358

0.427

  1. The value of triglyceride was presented as median (interquartile range) for not meet the normal distribution, the difference among the genotypes was determined by the Kruskal–Wallis test. The P value calculated by ANCOVA, using general linear models, and adjusted for age, sex, BMI, smoking status, alcohol use, glucose and hypertension, P < 0.025 was considered statistically significant (corresponding to P < 0.05 after adjusting for 2 independent tests by the Bonferroni correction). n = sample size
  2. TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, ApoA1/ApoB the ratio of apolipoprotein A1 to apolipoprotein B
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Nutrition & Metabolism

ISSN: 1743-7075

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