|
Genotype
|
n
|
TC (mmol/L)
|
TG (mmol/L)
|
HDL-C (mmol/L)
|
LDL-C (mmol/L)
|
ApoA1 (g/L)
|
ApoB (g/L)
|
ApoA1 /ApoB
|
|---|
|
SLC44A4 rs577272
|
|
Han
|
|
AA
|
394
|
4.75 ± 1.02
|
0.98(0.76)
|
1.71 ± 0.45
|
2.70 ± 0.93
|
1.43 ± 0.27
|
0.84 ± 0.24
|
1.81 ± 0.50
|
|
AG + GG
|
860
|
4.86 ± 0.98
|
1.06 (0.83)
|
1.73 ± 0.57
|
2.74 ± 0.84
|
1.44 ± 0.29
|
0.83 ± 0.20
|
1.83 ± 0.62
|
|
F
| |
5.650
|
− 0.601
|
1.527
|
2.674
|
1.320
|
1.482
|
2.873
|
|
P
| |
0.077
|
0.448
|
0.539
|
0.449
|
0.779
|
0.728
|
0.424
|
|
Han/Male
|
|
AA
|
117
|
4.95 ± 0.99
|
0.99 (0.83)
|
1.64 ± 0.43
|
2.78 ± 0.85
|
1.38 ± 0.22
|
0.80 ± 0.23
|
1.82 ± 0.51
|
|
AG + GG
|
442
|
5.15 ± 1.06
|
1.11 (0.78)
|
1.75 ± 0.53
|
2.92 ± 0.82
|
1.40 ± 0.26
|
0.80 ± 0.20
|
1.84 ± 0.61
|
|
F
| |
6.946
|
− 2.104
|
3.295
|
4.049
|
1.618
|
0.936
|
1.347
|
|
P
| |
0.047
|
0.035
|
0.311
|
0.123
|
0.632
|
0.955
|
0.768
|
|
Han/Female
|
|
AA
|
277
|
4.56 ± 1.15
|
0.92 (0.68)
|
1.84 ± 0.45
|
2.61 ± 0.96
|
1.53 ± 0.29
|
0.91 ± 0.26
|
1.83 ± 0.50
|
|
AG + GG
|
418
|
4.78 ± 1.01
|
1.04 (0.82)
|
1.69 ± 0.61
|
2.70 ± 0.83
|
1.49 ± 0.32
|
0.90 ± 0.28
|
1.80 ± 0.63
|
|
F
| |
7.633
|
− 1.991
|
8.117
|
3.884
|
7.189
|
0.980
|
3.669
|
|
P
| |
0.018
|
0.046
|
0.011
|
0.200
|
0.032
|
0.856
|
0.231
|
|
Maonan
|
|
AA
|
309
|
4.80 ± 1.12
|
1.09 (0.78)
|
1.63 ± 0.56
|
2.83 ± 0.88
|
1.35 ± 0.27
|
0.86 ± 0.25
|
1.69 ± 0.53
|
|
AG + GG
|
904
|
5.03 ± 1.01
|
1.11 (0.89)
|
1.50 ± 0.45
|
2.85 ± 0.79
|
1.38 ± 0.31
|
0.90 ± 0.22
|
1.67 ± 0.66
|
|
F
| |
7.760
|
− 0.274
|
7.746
|
1.515
|
2.958
|
3.173
|
1.525
|
|
P
| |
0.012
|
0.784
|
0.015
|
0.682
|
0.381
|
0.318
|
0.679
|
|
Maonan/Male
|
|
AA
|
46
|
4.70 ± 0.94
|
0.97 (0.57)
|
1.65 ± 0.41
|
2.72 ± 0.82
|
1.37 ± 0.30
|
0.85 ± 0.17
|
1.69 ± 0.46
|
|
AG + GG
|
419
|
4.94 ± 0.83
|
1.07 (0.76)
|
1.56 ± 0.43
|
2.80 ± 0.75
|
1.37 ± 0.37
|
0.87 ± 0.21
|
1.66 ± 0.65
|
|
F
| |
8.088
|
− 1.032
|
3.800
|
3.569
|
0.925
|
1.506
|
3.862
|
|
P
| |
0.004
|
0.302
|
0.205
|
0.256
|
0.963
|
0.553
|
0.226
|
|
Maonan/Female
|
|
AA
|
263
|
4.87 ± 1.04
|
1.15 (0.90)
|
1.59 ± 0.68
|
2.89 ± 0.85
|
1.34 ± 0.25
|
0.87 ± 0.25
|
1.69 ± 0.50
|
|
AG + GG
|
485
|
5.08 ± 1.12
|
1.27 (1.04)
|
1.45 ± 0.72
|
2.95 ± 0.92
|
1.39 ± 0.24
|
0.92 ± 0.23
|
1.69 ± 0.64
|
|
F
| |
7.717
|
− 1.159
|
7.901
|
3.085
|
7.246
|
6.432
|
0.945
|
|
P
| |
0.015
|
0.246
|
0.013
|
0.352
|
0.030
|
0.055
|
0.923
|
|
NOTCH4 rs3134931
|
|
Han
|
|
GG
|
315
|
4.80 ± 1.05
|
0.86 (0.82)
|
1.77 ± 0.58
|
2.63 ± 0.86
|
1.47 ± 0.33
|
0.81 ± 0.21
|
1.83 ± 0.62
|
|
AG + AA
|
939
|
4.83 ± 1.07
|
1.26 (0.88)
|
1.71 ± 0.52
|
2.73 ± 0.87
|
1.42 ± 0.27
|
0.84 ± 0.21
|
1.79 ± 0.57
|
|
F
| |
1.548
|
− 7.020
|
4.333
|
5.731
|
1.747
|
1.536
|
3.026
|
|
P
| |
0.524
|
0.000
|
0.114
|
0.074
|
0.481
|
0.532
|
0.341
|
|
Han/Male
|
|
GG
|
163
|
4.89 ± 0.97
|
0.80 (0.79)
|
1.71 ± 0.69
|
2.75 ± 0.86
|
1.35 ± 0.29
|
0.78 ± 0.21
|
1.81 ± 0.52
|
|
AG + AA
|
396
|
5.04 ± 1.04
|
1.10 (0.85)
|
1.54 ± 0.41
|
2.82 ± 0.79
|
1.39 ± 0.23
|
0.81 ± 0.21
|
1.83 ± 0.45
|
|
F
| |
4.416
|
− 3.528
|
7.696
|
3.123
|
1.416
|
3.924
|
1.458
|
|
P
| |
0.109
|
0.017
|
0.014
|
0.323
|
0.731
|
0.180
|
0.557
|
|
Han/Female
|
|
GG
|
152
|
4.68 ± 1.12
|
0.98 (0.79)
|
1.83 ± 0.45
|
2.62 ± 0.90
|
1.60 ± 0.31
|
0.83 ± 0.22
|
1.90 ± 0.45
|
|
AG + AA
|
543
|
4.68 ± 1.06
|
1.30 (0.85)
|
1.87 ± 0.58
|
2.67 ± 0.88
|
1.48 ± 0.30
|
0.89 ± 0.21
|
1.73 ± 0.56
|
|
F
| |
0.836
|
− 4.038
|
2.989
|
1.612
|
5.576
|
2.726
|
2.874
|
|
P
| |
0.992
|
0.008
|
0.404
|
0.526
|
0.089
|
0.432
|
0.388
|
|
Maonan
|
|
GG
|
352
|
4.90 ± 0.91
|
0.99 (0.86)
|
1.57 ± 0.43
|
2.76 ± 0.80
|
1.39 ± 0.25
|
0.84 ± 0.20
|
1.71 ± 0.48
|
|
AG + AA
|
861
|
5.03 ± 1.01
|
1.34 (0.84)
|
1.55 ± 0.50
|
2.92 ± 0.86
|
1.36 ± 0.31
|
0.90 ± 0.24
|
1.65 ± 0.57
|
|
F
| |
7.035
|
− 4.444
|
1.097
|
7.241
|
3.914
|
2.676
|
1.422
|
|
P
| |
0.041
|
0.000
|
0.815
|
0.022
|
0.186
|
0.443
|
0.742
|
|
Maonan/Male
|
|
GG
|
78
|
4.82 ± 1.02
|
0.94 (0.73)
|
1.65 ± 0.45
|
2.59 ± 0.79
|
1.39 ± 0.27
|
0.83 ± 0.25
|
1.72 ± 0.45
|
|
AG + AA
|
387
|
4.93 ± 1.05
|
1.23 ± 0.81
|
1.62 ± 0.37
|
2.80 ± 0.83
|
1.37 ± 0.38
|
0.86 ± 0.34
|
1.70 ± 0.47
|
|
F
| |
5.128
|
− 3.872
|
3.968
|
7.463
|
1.506
|
1.578
|
1.433
|
|
P
| |
0.088
|
0.012
|
0.167
|
0.016
|
0.543
|
0.528
|
0.634
|
|
Maonan/Female
|
|
GG
|
274
|
5.04 ± 1.11
|
1.05 (0.70)
|
1.52 ± 0.43
|
2.81 ± 0.72
|
1.39 ± 0.33
|
0.85 ± 0.23
|
1.70 ± 0.45
|
|
AG + AA
|
474
|
5.12 ± 1.20
|
1.40 (0.80)
|
1.40 ± 0.52
|
3.04 ± 0.80
|
1.36 ± 0.29
|
0.92 ± 0.30
|
1.63 ± 0.43
|
|
F
| |
4.003
|
− 4.569
|
7.087
|
7.982
|
3.756
|
2.973
|
2.823
|
|
P
| |
0.125
|
0.000
|
0.017
|
0.008
|
0.195
|
0.358
|
0.427
|
- The value of triglyceride was presented as median (interquartile range) for not meet the normal distribution, the difference among the genotypes was determined by the Kruskal–Wallis test. The P value calculated by ANCOVA, using general linear models, and adjusted for age, sex, BMI, smoking status, alcohol use, glucose and hypertension, P < 0.025 was considered statistically significant (corresponding to P < 0.05 after adjusting for 2 independent tests by the Bonferroni correction). n = sample size
- TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA1 apolipoprotein A1, ApoB apolipoprotein B, ApoA1/ApoB the ratio of apolipoprotein A1 to apolipoprotein B
