Fig. 2
S-Equol ameliorates insulin secretion failure in ZDF rats. ZDF rats were treated with or without Equol (120 mg/kg.BW.d) for six weeks, and ZLR rats were used as the control. (a) Serum insulin concentrations after 2, 4 and 6 weeks treatment; (b) Serum C-peptide and (c) glucagon levels after 6 weeks treatment; (d) Serum insulin levels during OGTT after 6 weeks treatment. Following an overnight fast, rats were injected with glucose (2.0 g/kg.BW). Insulin values were assessed at 0, 15, 30, 60, 90 and 120 min during OGTT. (g) GSIS from isolated islets. Batches of 3 isolated pancreatic islets were stimulated with 2.8 mm or 16.7 mm glucose for 30 min. Amplification rate of insulin secretion (h) at high (16.7 mM) glucose compared with basal (2.8 mM) glucose stimulation for 30 min. Eq, Equol; ZDF, Zucker diabetic fatty rats (fa/fa); ZLR, Zucker lean rats (fa/+); GSIS, glucose stimulated insulin secretion. Data are presented as means ± S. D (n = 6), # P < 0.05 vs. the ZLR group; * P < 0.05 vs. the ZDF group