Skip to main content

Table 5 Hazard ratios of metabolic syndrome across tertiles of nut consumption according to transcription factor-7-like 2 rs7903146 and rs12255372 genotype among participant with weigh change ≥ 7% during follow-up

From: TCF7L2 polymorphisms, nut consumption, and the risk of metabolic syndrome: a prospective population based study

  Tertiles of nut consumption
T1 T2 T3 Ptrenda
Rs7903146     
CC     
 Model 1 1 1.21 (0.72–2.03) 1.05 (0.62–1.78) 0.74
 Model 2 1 1.33 (0.77–2.26) 105 (0.61–1.81) 0.51
CT  
 Model 1 1 0.58 (0.37–0.91) 0.54 (0.33–0.85) 0.01
 Model 2 1 0.57 (0.35–0.92) 0.49 (0.30–0.79) 0.007
TT  
 Model 1 1 1.14 (0.59–2.20) 0.91 (0.45–1.83) 0.80
 Model 2 1 1.25 (0.58–2.69) 0.69 (0.31–1.51) 0.27
CT + TT  
 Model 1 1 0.70 (0.48–1.01) 0.59 (0.40–0.87) 0.02
 Model 2 1 0.67 (0.46–0.97) 0.55 (0.37–0.82) 0.009
Rs12255372  
GG  
 Model 1 1 1.02 (0.62–1.71) 1.04 (0.63–1.72) 0.98
 Model 2 1 1.06 (0.63–1.80) 1.09 (0.65–1.82) 0.94
GT  
 Model 1 1 0.58 (0.36–1.12) 0.75 (0.49–1.16) 0.37
 Model 2 1 0.57 (0.35–1.12) 0.74 (0.47–1.17) 0.38
TT  
 Model 1 1 0.85 (0.41–1.77) 0.68 (0.31–1.46) 0.34
 Model 2 1 0.60 (0.25–1.43) 0.36 (0.14–1.10) 0.14
GT + TT  
 Model 1 1 0.60 (0.41–1.09) 0.71 (0.49–1.03) 0.16
 Model 2 1 0.60 (0.45–1.09) 0.71 (0.49–1.03) 0.10
  1. Model 1 was crude
  2. Model 2 was adjusted for age, gender, smoking, physical activity, education levels, occupational status, total energy intake, fiber intake, family history of diabetes, family history of cardiovascular disease
  3. aThe median intake of each tertile category was assigned and then these quartile median variables were included as a continuous variable in cox proportional hazards regression