Fig. 5
From: Lotus leaf extract inhibits ER− breast cancer cell migration and metastasis
LAE effect on tumor metastasis in xenograft model. a Flowchart of animal experiments. MDA-MB-231 (5 × 107) were subcutaneously injected in the right flank of mice. After 1 week of injection, the tumor bearing mice were randomly subdivided into 2 groups: Control; 0.5% LAE. b Growth curves of body weight in xenograft model. c Upper panel: Representative tumors and weight of tumors. Lower panel: Growth curves of tumor volume in xenograft model. d The numbers and weights of new metastatic tumors derived from the primary tumor. e p-SMAD3 and p-Erk1/2 proteins levels were examined by immunoblotting in lung and liver tissues (xenograft model)