Potential mediators | Non-obesity | Obesity | ||||||
---|---|---|---|---|---|---|---|---|
Total effect | Controlled direct effect | Natural indirect effect | Proportion mediated (%) | Total effect | Controlled direct effect | Natural indirect effect | Proportion mediated (%) | |
Men | ||||||||
 HOMA-IR | 1.58 (1.20–2.06) | 1.41 (1.08–1.82) | 1.13 (1.05–1.24) | 30.8 | 1.36 (1.08–1.68) | 1.31 (1.03–1.62) | 1.04 (1.00–1.09) | 14.5 |
 Fasting glucose | 1.57 (1.21–2.03) | 1.57 (1.21–2.02) | 1.00 (0.99–1.02) | 0.9 | 1.36 (1.09–1.72) | 1.36 (1.09–1.73) | 1.00 (0.98–1.02) | − 1.0 |
 Total cholesterol | 1.58 (1.25–1.96) | 1.57 (1.23–1.94) | 1.00 (0.96–1.05) | 0.7 | 1.36 (1.09–1.69) | 1.31 (1.04–1.63) | 1.04 (1.00–1.09) | 13.7 |
 Triglycerides | 1.59 (1.24–2.11) | 1.50 (1.18–1.96) | 1.06 (1.01–1.15) | 15.4 | 1.35 (1.07–1.7) | 1.28 (1.01–1.63) | 1.06 (1.01–1.13) | 20.7 |
 HDL-C | 1.60 (1.24–2.03) | 1.48 (1.16–1.92) | 1.08 (1.02–1.17) | 19.2 | 1.36 (1.08–1.72) | 1.36 (1.08–1.71) | 1.00 (0.99–1.02) | 1.2 |
 LDL-C | 1.56 (1.23–1.98) | 1.53 (1.20–1.93) | 1.02 (0.97–1.08) | 5.5 | 1.36 (1.08–1.76) | 1.34 (1.06–1.74) | 1.02 (0.99–1.05) | 5.6 |
 SBP | 1.59 (1.24–2.04) | 1.53 (1.20–1.93) | 1.04 (0.99–1.09) | 9.5 | 1.36 (1.08–1.75) | 1.34 (1.06–1.70) | 1.02 (0.99–1.05) | 6.0 |
 White blood cells | 1.55 (1.17–1.98) | 1.43 (1.09–1.79) | 1.09 (1.02–1.16) | 22.1 | 1.40 (1.12–1.77) | 1.37 (1.08–1.74) | 1.03 (0.99–1.09) | 9.8 |
Women | ||||||||
 HOMA-IR | 1.48 (1.23–1.79) | 1.40 (1.17–1.70) | 1.05 (1.02–1.09) | 15.1 | 1.30 (1.11–1.52) | 1.25 (1.06–1.45) | 1.04 (1.01–1.08) | 17.3 |
 Fasting glucose | 1.45 (1.21–1.73) | 1.46 (1.22–1.73) | 1.00 (0.99–1.00) | − 0.7 | 1.30 (1.11–1.54) | 1.31 (1.12–1.57) | 0.99 (0.97–1.00) | − 4.1 |
 Total cholesterol | 1.46 (1.21–1.78) | 1.43 (1.20–1.73) | 1.02 (1.00–1.05) | 7.1 | 1.29 (1.10–1.51) | 1.29 (1.10–1.50) | 1.01 (1.00–1.02) | 2.4 |
 Triglycerides | 1.47 (1.23–1.77) | 1.34 (1.12–1.63) | 1.10 (1.06–1.14) | 27.4 | 1.30 (1.11–1.53) | 1.28 (1.09–1.49) | 1.02 (0.99–1.05) | 7.2 |
 HDL-C | 1.49 (1.25–1.81) | 1.41 (1.18–1.70) | 1.06 (1.03–1.10) | 16.9 | 1.31 (1.11–1.56) | 1.29 (1.10–1.52) | 1.02 (0.99–1.04) | 6.3 |
 LDL-C | 1.46 (1.23–1.77) | 1.43 (1.20–1.74) | 1.02 (0.99–1.05) | 7.0 | 1.30 (1.12–1.52) | 1.29 (1.11–1.51) | 1.01 (1.00–1.02) | 2.8 |
 SBP | 1.46 (1.21–1.75) | 1.46 (1.21–1.76) | 1.00 (0.98–1.02) | 0.9 | 1.30 (1.12–1.56) | 1.29 (1.10–1.53) | 1.01 (1.00–1.03) | 4.8 |
 White blood cells | 1.48 (1.23–1.80) | 1.44 (1.20–1.75) | 1.02 (1.00–1.05) | 7.1 | 1.29 (1.09–1.51) | 1.26 (1.07–1.47) | 1.02 (1.00–1.05) | 9.2 |