Fig. 5

Global lipidome response in high-fat diet-treated rats. a, b Score plots of PCA and OPLS-DA in the HFD_vs_ND group (n = 6). c Volcano plot for the HFD_vs_ND group. Red dots represent significantly different lipids (FC > 1.5 p value < 0.05). d Heatmap visualization of the differentially abundant metabolites. e Analysis of the multiples of variation of significantly different lipid molecules in the HFD_vs_ND group