Integrative proteomic and lipidomic analysis of Kaili Sour Soup-mediated attenuation of high-fat diet-induced nonalcoholic fatty liver disease in a rat model

Table 1 Physiological and biochemical markers in the NAFLD rat model

Index	ND group	NDS group	HFD group	HFDS group
Body weight (g)	461.67 ± 23.89	462.67 ± 38.99	570.83 ± 23.02**	500.50 ± 23.72^∆∆
Liver weight (g)	14.81 ± 1.05	14.05 ± 1.98	21.01 ± 1.41**	19.24 ± 0.93^∆∆
Liver index (%)	3.21 ± 0.19	3.03 ± 0.32	3.68 ± 0.23**	3.85 ± 0.12^∆∆
Lee’s index	3.00 ± 0.08	3.05 ± 0.06	3.19 ± 0.05**	3.10 ± 0.10
TC (mmol/L)	1.43 ± 0.40	1.38 ± 0.30	2.59 ± 0.16**	2.19 ± 0.29^∆∆
TG (mmol/L)	0.64 ± 0.19	0.67 ± 0.39	1.47 ± 0.26**	1.09 ± 0.16^∆∆
ALT (U/L)	41.83 ± 6.76	44.87 ± 9.26	106.48 ± 18.35**	87.00 ± 8.10^∆
AST (U/L)	145.23 ± 17.95	182.08 ± 40.23	429.67 ± 56.46**	364.18 ± 40.04^∆∆
FBG(mmol/L)	8.01 ± 1.21	8.92 ± 2.07	13.36 ± 1.02**	12.22 ± 1.41
FINS (mIU/L)	22.27 ± 2.17	23.58 ± 1.05	31.80 ± 4.27**	29.31 ± 1.79
HOMA-IR	9.23 ± 1.44	11.25 ± 1.98	15.88 ± 2.12**	13.67 ± 0.53^∆
FINS (mIU/L)	10.55 ± 0.67	10.73 ± 1.62	18.82 ± 1.20**	16.03 ± 5.54^∆
HOMA-IR	3.78 ± 0.80	4.37 ± 1.75	11.17 ± 1.12**	8.80 ± 2.07^∆

Liver index = (liver weight/body weight) × 100%; Lee’s index = (weight × 1000)^(1/3)/length (cm); Total cholesterol (TC); Triglyceride TG; Alanine aminotransferase ALT; Aspartate aminotransferase AST; Fasting blood glucose FBG; Insulin level FINS; Insulin resistance level HOMA-IR = (FINS*FBG)/22.5. *p ≤ 0.05 and **p ≤ 0.01 represented statistically significance between HFD group and ND group; ^∆p ≤ 0.05 and ^∆∆p ≤ 0.01 represented statistically significance between HFDS group and HFD group. n = 6

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