Fig. 1
From: Metabolic reprogramming in cervical cancer and metabolomics perspectives
Metabolic regulation in cancer and cervical cancer. A Various cancers share several metabolic features in common. Here, we briefly illustrate typical characteristics of cancer metabolism. Generally, the uptake of glucose, amino acids and FAs is increased. Glycolysis is the leading energy source and consequently increases lactate production. Intermediates of glycolysis and glutamine metabolism are used for various biosynthesis pathways. De novo synthesis of FA is increased, and the generated FAs are further utilized in signal transduction, cellular component constitution and FAO. B Glycolysis, FA metabolism and amino acid metabolism are the most affected pathways in cervical cancer. The enzymes and transporters in the figure are all enhanced in cervical cancer or positively related to tumor aggressiveness. The figure was generated using PathVisio 3.0.0+ [102]