Associations of visceral adipose tissue with bone mineral density and fracture: observational and Mendelian randomization studies

Table 5 MR estimates of the causal effects of VAT^ on fractures

Method	Total fractures		Hip fractures		Vertebrae fractures
Method	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
MR Egger	0.67 (0.41, 1.10)	0.12	0.71 (0.32, 1.55)	0.39	0.93 (0.39, 2.26)	0.88
Weighted median	1.06 (0.93, 1.20)	0.42	0.99 (0.74, 1.32)	0.93	1.00 (0.73, 1.38)	0.98
Inverse variance weighted	1.03 (0.93, 1.15)	0.57	1.02 (0.84, 1.24)	0.83	1.06 (0.85, 1.32)	0.60
Simple mode	1.07 (0.68, 1.70)	0.77	0.87 (0.34, 2.24)	0.77	1.41 (0.48, 4.09)	0.53
Weighted mode	1.18 (0.77, 1.82)	0.44	0.92 (0.38, 2.23)	0.86	1.30 (0.48, 3.49)	0.61

MR mendelian randomization; VAT^ predicted values of VAT (visceral adipose tissue) mass; OR odds ratio; and CI confidence interval

ISSN: 1743-7075