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Table 2 The distributions of 26 SNPs in the fatty acid desaturases and elongases of the subjects in this study

From: Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study

Gene

SNPs

Call rate (%)

Allele*

Ratio#

Genotypes

All subjects (n = 1050)

Exogenous DHA-rich n-3 PUFAs supplementation groups (n = 434)

Control group (n = 616)

P&

S1 group (n = 172)

S2 group (n = 197)

S3 group (n = 65)

Fads1

rs174448

99.94

A

0.810

AA/GG/AG

695/39/316

112/7/53

131/7/59

44/3/18

408/22/186

0.991

rs174537

99.97

G

0.631

GG/TT/GT

419/141/490

68/24/80

79/24/94

26/9/30

246/84/286

0.988

rs174550

99.91

T

0.619

CC/TT/CT

155/409/486

27/64/81

27/78/92

10/25/30

91/242/283

0.377

rs174553

99.89

G

0.369

AA/GG/AG

424/152/474

68/26/78

81/27/89

26/10/29

249/89/278

0.830

Fads2

rs174598

99.18

A

0.361

AA/TT/AT

147/438/465

23/71/78

29/81/87

9/28/28

86/258/272

0.849

rs174602

99.84

C

0.743

CC/TT/CT

67/576/407

10/95/67

12/108/77

5/36/24

40/337/239

0.940

rs174609

99.89

T

0.824

CC/TT/CT

35/719/296

6/117/49

6/134/57

3/44/18

20/424/172

0.843

rs174619

99.42

G

0.766

AA/GG/AG

62/625/363

11/103/58

12/117/68

3/40/22

36/365/215

0.972

rs498793

100.00

C

0.921

CC/TT/CT

896/7/147

148/1/23

168/2/27

55/1/9

525/3/88

0.831

rs3168072

99.91

A

0.836

AA/TT/AT

743/33/274

122/5/45

140/6/51

46/2/17

435/20/161

0.992

Fads3

rs174455

100.00

C

0.702

CC/TT/CT

521/93/436

84/17/71

98/16/83

34/5/26

305/55/256

0.082

rs174464

99.84

G

0.785

AA/GG/AG

62/664/324

10/109/53

11/124/62

4/42/19

37/389/190

0.316

rs76996928

99.67

T

0.541

CC/TT/CT

239/327/484

39/54/79

46/60/91

15/20/30

139/193/284

0.773

Elovl2

rs1323739

99.49

G

0.676

CC/GG/CG

99/471/480

15/78/79

19/87/91

6/30/29

59/276/281

0.226

rs2295602

99.43

C

0.911

CC/TT/CT

878/11/116

145/2/25

165/2/30

54/1/10

514/6/96

0.996

rs2180725

100.00

T

0.759

CC/TT/CT

66/613/371

12/97/63

12/116/69

4/38/23

38/362/216

0.983

rs3798710

99.97

G

0.565

CC/GG/CG

205/344/501

32/58/82

39/64/94

13/21/31

121/201/294

0.939

rs78793420

99.49

T

0.759

CC/TT/CT

55/603/392

9/97/66

10/114/73

4/38/23

32/354/230

0.937

Elovl5

rs209512

100.00

A

0.435

AA/GG/AG

197/331/522

32/53/87

38/61/98

12/21/32

115/196/305

1.000

rs2281274

99.84

T

0.793

CC/TT/CT

40/660/350

7/109/56

7/125/65

3/41/21

23/385/208

0.919

rs2294852

99.75

C

0.616

CC/GG/CG

401/154/495

64/26/82

76/29/92

26/9/30

235/90/291

0.997

rs2397142

99.82

C

0.666

CC/GG/CG

479/127/444

79/20/73

90/23/84

30/8/27

280/76/260

0.908

rs6909592

99.94

G

0.605

CC/GG/CG

168/391/491

28/65/79

31/73/93

10/25/30

99/228/289

0.924

rs9349665

100.00

T

0.718

CC/TT/CT

91/550/409

14/91/67

17/103/77

6/35/24

54/321/241

0.776

rs9395858

99.86

C

0.710

CC/TT/CT

532/87/431

87/15/70

101/15/81

33/5/27

311/52/253

0.505

rs12207094

100.00

A

0.896

AA/TT/AT

845/9/196

139/2/31

158/2/37

52/1/12

496/4/116

0.774

  1. SNPs Single nucleotide polymorphisms, Fads Fatty acid desaturases, Elovl Elongase of very long chain fatty acid, PUFAs Polyunsaturated fatty acids
  2. *The effective alleles were determined according to the literature and the effect values which were positively associated between the genotypes of SNPs and contents of DHA in the colostrum
  3. #The ratio was calculated by the effective alleles/not-effective alleles
  4. &Data was analyzed by χ2 test among all these four groups. S1 group: exogenous DHA-rich n-3 PUFAs supplementation at the early pregnancy (0–12 week), S2 group: exogenous DHA-rich n-3 PUFAs supplementation at the middle pregnancy (13–27 week), S3 group: exogenous DHA-rich n-3 PUFAs supplementation at the late pregnancy (> 27 week), Control group: non-exogenous DHA-rich n-3 PUFAs supplementation during the whole pregnancy
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Nutrition & Metabolism

ISSN: 1743-7075

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