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Fig. 3 | Nutrition & Metabolism

Fig. 3

From: Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases

Fig. 3

WAT browning transcriptional regulation. The transcriptional regulation of the WAT beiging process involves the action of a plethora of specific proteins and nucleic acids. This orchestra of trans-acting factors modulates genes associated with oxidative capacity, mitochondrial biogenesis and non-shivering thermogenesis. While the action of some factors, such as PGC-1α, IRF4, PRDM16, ZFP516, EHMT1 and RNAs, copes with WAT browning, TLE3, ZFP423, and the NuRD complex, another set of RNAs e others inhibit this process, favoring adipogenesis and white adipocyte differentiation

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Nutrition & Metabolism

ISSN: 1743-7075

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