Fig. 2

Change in TyG index after LCD and modifications in BMI (kg/m²) for each type of randomized diet, A Change in BMI (kg/m²) corresponding to the complete nutritional intervention, (period 3, 0–34 weeks); B Change in BMI (kg/m²) concerning the maintenance nutritional intervention, (period 2, 8–34 weeks). Results shown are based on ITT analysis. Types of diets: Control (healthy diet), LP/LGI (low protein, low glycemic index diet), LP/HGI (low protein, high glycemic index diet), HP/LGI (high protein, low glycemic index diet), HP/HGI (high protein, high glycemic index diet). Only significant differences were obtained between Low Protein/High Glycemic Index and High Protein/Low Glycemic Index (HP/LGI) diet (p = 0.015). Period 3: Corresponds to the differences between baseline and final parameters, encompassing the complete nutritional period (during 34 weeks); Period 2: Corresponds to the differences between the parameters after the low-calorie diet intervention (8 weeks) and after the nutritional treatment focused on weight maintenance for each type of randomized diet (8–34 weeks)