Fig. 5
From: Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota
Curcumin regulates genes involved in hepatic gluconeogenesis and de novo lipogenesis through gut microbiota. A Real-time quantitative PCR analysis of Pck1 and G6pc expression in the liver from HFD-fed mice treated with curcumin or vehicle for 4 weeks (n = 6/group). B Real-time quantitative PCR analysis of genes involved in DNL in the liver from mice in A (n = 6/group). C, D Real-time quantitative PCR analysis of Pck1 and G6pc expression (C) and genes involved in DNL (D) in the liver from vehicle- and curcumin-treated HFD-fed mice after antibiotic treatment (n = 6/group). E, F Real-time quantitative PCR analysis of Pck1 and G6pc expression (E) and genes involved in DNL (F) in the liver from endogenous gut microbiota-depleted mice colonized with the microbiota harvested from curcumin- and vehicle-treated HFD-fed mice (n = 6/group). Numerical data are shown as the mean ± SEM. *P < 0.05, **P < 0.01