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Fig. 7 | Nutrition & Metabolism

Fig. 7

From: A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice

Fig. 7

MC903 treatment increased UCP3 expression in muscles in vivo and in vitro. A-F Gene expressions in the gastrocnemius (A-C) and soleus muscles (D-F). G-I C2C12 myoblasts were differentiated into myotubes in the absence (control) or presence of VitD3 or MC903, and the expression of Pgc1a, Myostatin, and Ucp3 was analyzed. J UCP3 protein levels in knockdown myotubes. K, L OCR and maximum OCR in myotubes. Data are presented as the mean ± SEM. N = 6–9 (A-I), 3 (J) or 5–6 (K, L). A-F *p < 0.05, **p < 0.01 significantly different from Chow mice; †p < 0.05, ††p < 0.01 significantly different from HFD mice. G-L *p < 0.05, **p < 0.01 significantly different from control; ††p < 0.01 significantly different from MC903-treated myotubes

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Nutrition & Metabolism

ISSN: 1743-7075

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