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Table 1 Associations of metabolomics z-score with baseline characteristics of participants included in analysis

From: Prospective association between an obesogenic dietary pattern in early adolescence and metabolomics derived and traditional cardiometabolic risk scores in adolescents and young adults from the ALSPAC cohort

 

Participants at age 15

(n = 1808)

Metabolomics z-score at

age 15

Participants at age 17

(n = 1629)

Metabolomics z-score at

age 17

Participants at age 24

(n = 1760)

Metabolomics z-score at

age 24

n (%)

Mean (95% CI)

P

trend

n (%)

Mean (95% CI)

P

trend

n (%)

Mean (95% CI)

P

trend

Sex

         

 Male

838 (46.3)

Ref

 

781 (47.9)

Ref

 

732 (41.6)

Ref

 

 Female

970 (53.7)

-0.08 (-0.15, 0.00)

0.071

848 (52.1)

-0.01 (-0.19, 0.00)

0.053

1028 (58.4)

0.1 (0.00, 0.20)

0.034

Social class a

         

 I, II, III non-manual

1089 (60.2)

Ref

 

1018 (62.5)

Ref

 

1120 (63.6)

Ref

 

 III manual, IV, V

719 (39.8)

0.07 (-0.02, 0.16)

0.140

611 (37.5)

0.40 (-0.06, 0.14)

0.432

640 (36.4)

0.09 (0.00, 0.19)

0.076

Maternal educational level b

         

 A-level or degree

914 (50.5)

Ref

 

860 (52.8)

Ref

 

935 (53.1)

Ref

 

 O-level

603 (33.4)

0.12 (0.15, 0.22)

 

518 (31.8)

0.14 (0.03, 0.25)

 

583 (33.1)

0.18 (0.08, 0.28)

 

 Vocational

128 (7.1)

-0.03 (-0.22, 0.15)

 

113 (6.9)

-0.08 (-0.28, 0.11)

 

101 (5.7)

0.02 (-0.18, 0.23)

 

 CSE or none

163 (9.0)

0.02 (-0.14, 0.19)

0.125

138 (8.5)

0.10 (-0.14, 0.19)

0.035

141 (8.0)

0.10 (-0.09, 0.27)

< 0.001

Physical activity level age 13c

         

 Inactive (< 60 MVPA/day)

1191 (65.9)

Ref

 

1077 (66.1)

Ref

 

1218 (69.2)

Ref

 

 Active (≥ 60 MVPA/day)

617 (34.1)

-0.02 (-0.12, 0.07)

0.610

552 (33.9)

0.00 (-0.10, 0.10)

0.961

542 (30.8)

-0.02 (-0.12, 0.08)

0.658

BMI d

         

 Obese

76 (4.2)

0.42 (0.19, 0.65)

 

63 (3.9)

0.44 (0.18, 0.69)

 

72 (4.1)

0.58 (0.34, 0.82)

 

 Overweight

322 (17.8)

0.08 (-0.04, 0.20)

 

269 (16.6)

0.05 (-0.08, 0.18)

 

301 (17.1)

0.19 (0.06, 0.31)

 

 Normal

 Underweight

1322 (73.2)

85 (4.7)

Ref

0.12 (-0.09, 0.34)

0.003

1212 (74.6)

81 (5.0)

Ref

-0.14 (-0.37, 0.08)

0.003

1287 (73.1)

101 (5.7)

Ref

-0.07 (-0.27, 0.13)

< 0.001

Dietary misreporting e

         

 Over-reporting

19 (1.1)

0.43 (-0.03, 0.88)

 

16 (1.0)

-0.16 (-0.65, 0.34)

 

13 (0.7)

-0.01 (-0.55, 0.53)

 

 Plausible reporting

677 (37.4)

Ref

 

640 (39.4)

Ref

 

697 (39.6)

Ref

 

 Under-reporting

1112 (61.5)

0.03 (-0.06, 0.12)

0.174

973 (59.6)

0.08 (-0.02, 0.18)

0.23

1050 (59.7)

0.12 (0.02, 0,22)

0.051

  1. a I, II, III non-manual social class categories correspond to the highest one, and III manual, IV and V to the lowest. b A-level or degree correspond to the highest maternal educational level, and CSE or none to the lowest .c Sufficient physical activity data was only available at age 13. d BMI sex-specific cut off points were obtained at age 13 from the International Obesity Task Force.e Dietary misreporting was based on the ratio of energy intake to estimated energy requirement (EER) at age 13. Abbreviations = BMI: Body mass index. MVPA : Moderate-to-vigorous physical activity
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Nutrition & Metabolism

ISSN: 1743-7075

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