From: Healthy lifestyle scores associate with incidence of type 2 diabetes mediated by uric acid
Effects | SUA# (µmol/L) | Hyperuricemia†| ||||||
---|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 1 | Model 2 | |||||
β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | β (95% CI) | P | |
Total effects | − 0.022 (− 0.033, − 0.013) |  < 0.001 | − 0.016 (− 0.021, − 0.009) |  < 0.001 | − 0.024 (− 0.034, − 0.014) |  < 0.001 | − 0.017 (− 0.028, − 0.010) |  < 0.001 |
Direct effects | − 0.019 (− 0.028, − 0.010) |  < 0.001 | − 0.014 (− 0.025, − 0.010) |  < 0.001 | − 0.020 (− 0.029, − 0.011) |  < 0.001 | − 0.014 (− 0.024, − 0.009) |  < 0.001 |
Indirect effects | − 0.003 (− 0.006, − 0.001) |  < 0.001 | − 0.002 (− 0.004, − 0.002) |  < 0.001 | − 0.004 (− 0.005, − 0.002) |  < 0.001 | − 0.003 (− 0.004, − 0.001) |  < 0.001 |
Proportion of mediation (%) * | 14.38 (5.28, 26.01) |  < 0.001 | 13.06 (6.29, 30.22) |  < 0.001 | 16.07 (9.87, 27.18) |  < 0.001 | 15.71 (6.69, 33.12) |  < 0.001 |