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  1. Methodology

    Press-pulse: a novel therapeutic strategy for the metabolic management of cancer

    A shift from respiration to fermentation is a common metabolic hallmark of cancer cells. As a result, glucose and glutamine become the prime fuels for driving the dysregulated growth of tumors. The simultaneou...

    Thomas N. Seyfried, George Yu, Joseph C. Maroon and Dominic P. D’Agostino

    Nutrition & Metabolism 2017 14:19

    Published on: 23 February 2017

  2. Research

    Long-term intake of saccharin decreases post-absortive energy expenditure at rest and is associated to greater weight gain relative to sucrose in wistar rats

    Non-nutritive sweeteners (NNS) have been associated with increased prevalence of obesity. In previous studies, we demonstrated that saccharin could induce an increase in weight gain either when compared to suc...

    Denise Entrudo Pinto, Kelly Carraro Foletto, Ramiro Barcos Nunes, Pedro Dal Lago and Marcello Casaccia Bertoluci

    Nutrition & Metabolism 2017 14:18

    Published on: 20 February 2017

  3. Research

    Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet

    Nutritional status in early life is critically involved in the metabolic phenotype of offspring. However the changes triggered by maternal consumption of high-fat diet (HFD) in pre- or postnatal period should ...

    Laís Angélica de Paula Simino, Thaís de Fante, Marina Figueiredo Fontana, Fernanda Oliveira Borges, Márcio Alberto Torsoni, Marciane Milanski, Lício Augusto Velloso and Adriana Souza Torsoni

    Nutrition & Metabolism 2017 14:16

    Published on: 20 February 2017

  4. Research

    Impact of a 6-week non-energy-restricted ketogenic diet on physical fitness, body composition and biochemical parameters in healthy adults

    The ketogenic diet (KD) is a very low-carbohydrate, high-fat and adequate-protein diet that without limiting calories induces different metabolic adaptations, eg, increased levels of circulating ketone bodies ...

    Paul Urbain, Lena Strom, Lena Morawski, Anja Wehrle, Peter Deibert and Hartmut Bertz

    Nutrition & Metabolism 2017 14:17

    Published on: 20 February 2017

  5. Brief communication

    High-cholesterol diet does not alter gut microbiota composition in mice

    Western diet containing both saturated fat and cholesterol impairs cardio-metabolic health partly by modulating diversity and function of the microbiota. While diet containing only high fat has comparable effe...

    Lidiya G. Dimova, Nikola Zlatkov, Henkjan J. Verkade, Bernt Eric Uhlin and Uwe J. F. Tietge

    Nutrition & Metabolism 2017 14:15

    Published on: 16 February 2017

  6. Research

    Hepatic iron storage is related to body adiposity and hepatic inflammation

    Obesity has been reported to be associated with iron deficiency. However, few studies have investigated iron status in low adiposity. To investigate whether body adiposity was associated with altered hepatic i...

    Chan Yoon Park, Jayong Chung, Kyung-Ok Koo, Min Soo Kim and Sung Nim Han

    Nutrition & Metabolism 2017 14:14

    Published on: 13 February 2017

  7. Research

    Supplementation with dairy calcium and/or flaxseed fibers in conjunction with orlistat augments fecal fat excretion without altering ratings of gastrointestinal comfort

    Orlistat is a lipase inhibitor which reduced absorption of dietary fat by ~30% thereby inducing a weight loss; however, side effects occur as a consequence of increased colonic fat content. To test the hypothe...

    Mette Kristensen, Signe Rømer Juul, Karina Vejrum Sørensen, Janne Kunchel Lorenzen and Arne Astrup

    Nutrition & Metabolism 2017 14:13

    Published on: 7 February 2017

  8. Research

    Weight loss technology for people with treated type 2 diabetes: a randomized controlled trial

    The prevalence of type 2 diabetes is increasing in worldwide despite the development of new treatment methods. Aim of the study was to evaluate a weight loss method on body composition, glycemic, lipid and hor...

    Kuat Oshakbayev, Bibazhar Dukenbayeva, Gulnar Togizbayeva, Aigul Durmanova, Meruyert Gazaliyeva, Abdul Sabir, Aliya Issa and Alisher Idrisov

    Nutrition & Metabolism 2017 14:11

    Published on: 31 January 2017

  9. Research

    Dietary supplementation with bovine-derived milk fat globule membrane lipids promotes neuromuscular development in growing rats

    The milk fat globule membrane (MFGM) is primarily composed of polar phospho- and sphingolipids, which have established biological effects on neuroplasticity. The present study aimed to investigate the effect o...

    James F. Markworth, Brenan Durainayagam, Vandre C. Figueiredo, Karen Liu, Jian Guan, Alastair K. H. MacGibbon, Bertram Y. Fong, Aaron C. Fanning, Angela Rowan, Paul McJarrow and David Cameron-Smith

    Nutrition & Metabolism 2017 14:9

    Published on: 23 January 2017

  10. Research

    High fat diet modifies the association of lipoprotein lipase gene polymorphism with high density lipoprotein cholesterol in an Asian Indian population

    Single nucleotide polymorphisms (SNPs) in lipoprotein lipase gene (LPL) have been shown to influence metabolism related to lipid phenotypes. Dietary factors have been shown to modify the association between LPL S...

    K. A. Ayyappa, I. Shatwan, D. Bodhini, L. R. Bramwell, K. Ramya, V. Sudha, R. M. Anjana, J. A. Lovegrove, V. Mohan, V. Radha and K. S. Vimaleswaran

    Nutrition & Metabolism 2017 14:8

    Published on: 19 January 2017

  11. Research

    Efficacy of a novel formulation of L-Carnitine, creatine, and leucine on lean body mass and functional muscle strength in healthy older adults: a randomized, double-blind placebo-controlled study

    Progressive decline in skeletal muscle mass and function are growing concerns in an aging population. Diet and physical activity are important for muscle maintenance but these requirements are not always met. ...

    Malkanthi Evans, Najla Guthrie, John Pezzullo, Toran Sanli, Roger A. Fielding and Aouatef Bellamine

    Nutrition & Metabolism 2017 14:7

    Published on: 18 January 2017

  12. Research

    Reduced up-regulation of the nitric oxide pathway and impaired endothelial and smooth muscle functions in the female type 2 diabetic goto-kakizaki rat heart

    Type 2 diabetes is associated with greater relative risk of cardiovascular diseases in women than in men, which is not well understood. Consequently, we have investigated if male and female displayed differenc...

    Martine Desrois, Carole Lan, Jamileh Movassat and Monique Bernard

    Nutrition & Metabolism 2017 14:6

    Published on: 13 January 2017

  13. Research

    Regulatory landscape of AGE-RAGE-oxidative stress axis and its modulation by PPARγ activation in high fructose diet-induced metabolic syndrome

    The AGE-RAGE-oxidative stress (AROS) axis is involved in the onset and progression of metabolic syndrome induced by a high-fructose diet (HFD). PPARγ activation is known to modulate metabolic syndrome; however...

    Luca Cannizzaro, Giuseppe Rossoni, Federica Savi, Alessandra Altomare, Cristina Marinello, Thammakorn Saethang, Marina Carini, D. Michael Payne, Trairak Pisitkun, Giancarlo Aldini and Asada Leelahavanichkul

    Nutrition & Metabolism 2017 14:5

    Published on: 13 January 2017

  14. Research

    Thylakoids reduce body fat and fat cell size by binding to dietary fat making it less available for absorption in high-fat fed mice

    Dietary thylakoids derived from spinach have beneficial effects on body fat accumulation and blood lipids as demonstrated in humans and rodents. Important mechanisms established include delayed fat digestion i...

    Karin G. Stenkula, Eva-Lena Stenblom, Caroline Montelius, Emil Egecioglu and Charlotte Erlanson-Albertsson

    Nutrition & Metabolism 2017 14:4

    Published on: 11 January 2017

  15. Research

    Evaluation of Lactobacillus coryniformis CECT5711 strain as a coadjuvant in a vaccination process: a randomised clinical trial in healthy adults

    Although the effects of probiotics on the immune system have been extensively evaluated under disease states, their role in healthy situations remains unclear, since changes are hardly expected under immunolog...

    Noemí Redondo, Esther Nova, Alina Gheorghe, Ligia Esperanza Díaz, Aurora Hernández and Ascensión Marcos

    Nutrition & Metabolism 2017 14:2

    Published on: 5 January 2017

  16. Research

    Plasticity of adipose tissue in response to fasting and refeeding in male mice

    Fasting is the most widely prescribed and self-imposed strategy for treating excessive weight gain and obesity, and has been shown to exert a number of beneficial effects. The aim of the present study was to d...

    Hao-Neng Tang, Chen-Yi Tang, Xiao-Fei Man, Shu-Wen Tan, Yue Guo, Jun Tang, Ci-La Zhou and Hou-De Zhou

    Nutrition & Metabolism 2017 14:3

    Published on: 5 January 2017

  17. Review

    Do metabolic syndrome and its components have an impact on bone mineral density in adolescents?

    In recent years, there has been growing concern about the occurrence of metabolic syndrome (MetS) at an early age and its effects on bone mass in adolescents. Adolescence is considered a critical period for bo...

    Valéria Nóbrega da Silva, Luciana Nunes Mosca Fiorelli, Carla Cristiane da Silva, Cilmery Suemi Kurokawa and Tamara Beres Lederer Goldberg

    Nutrition & Metabolism 2017 14:1

    Published on: 4 January 2017

  18. Review

    Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review

    The positive influences of glucagon-like peptide-1 (GLP-1) on blood glucose homeostasis, appetite sensations, and food intake provide a strong rationale for its therapeutic potential in the nutritional managem...

    Alexandra M. Bodnaruc, Denis Prud’homme, Rosanne Blanchet and Isabelle Giroux

    Nutrition & Metabolism 2016 13:92

    Published on: 9 December 2016

  19. Research

    Effects of controlled doses of Oxyelite Pro on physical performance in rats

    OxyElite Pro (OEP) is a dietary supplement to increase metabolism which contains as key stimulant the ingredient 1,3-dimethylamylamine (DMAA). Serious adverse effects have been reported after OEP consumption h...

    Paulo Vinicios Camuzi Zovico, Victor Magalhães Curty, Marcos André Soares Leal, Eduardo Frizzera Meira, Daniel Ventura Dias, Lívia Carla de Melo Rodrigues, Silvana dos Santos Meyrelles, Edilamar Menezes De Oliveira, Paula Frizera Vassallo and Valério Garrone Barauna

    Nutrition & Metabolism 2016 13:90

    Published on: 6 December 2016

  20. Research

    Alpha-mangostin from mangosteen (Garcinia mangostana Linn.) pericarp extract reduces high fat-diet induced hepatic steatosis in rats by regulating mitochondria function and apoptosis

    Non-alcoholic fatty liver disease (NAFLD) is caused by multiple factors including hepatic oxidative stress, lipotoxicity, and mitochondrial dysfunction. Obesity is among the risk factors for NAFLD alongside ty...

    Shin-Yu Tsai, Pei-Chin Chung, Eddy E. Owaga, I-Jong Tsai, Pei-Yuan Wang, Jeng-I Tsai, Tien-Shun Yeh and Rong-Hong Hsieh

    Nutrition & Metabolism 2016 13:88

    Published on: 1 December 2016

  21. Research

    Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling

    Obesity is still considered a risk factor for cardiovascular disease, although more recent knowledge also suggests obesity to be associated with reduced morbidity and mortality - the “obesity paradox”. This st...

    F. Edland, A. Wergeland, R. Kopperud, K. S. Åsrud, E. A. Hoivik, S. L. Witsø, R. Æsøy, L. Madsen, K. Kristiansen, M. Bakke, S. O. Døskeland and A. K. Jonassen

    Nutrition & Metabolism 2016 13:87

    Published on: 28 November 2016

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