- Letter to the Editor
- Open Access
Response to Dr. Roger’s letter: further studies are necessary in order to conclude a causal association between the consumption of monosodium L-glutamate (MSG) and the prevalence of metabolic syndrome in the rural Thai population
© Insawang et al.; licensee BioMed Central Ltd. 2013
Received: 21 December 2012
Accepted: 11 January 2013
Published: 15 January 2013
See related article: http://www.nutritionandmetabolism.com/content/10/1/14
Background & discussion
The number of participants (n = 315) in Pethlert et. al, 2011 is not the same as Insawang et. al, 2012 (n = 349) because it is different project and time setting. Pethlert project was run after Insawang project. Not all participants in Insawang project were recruited into Pethlert project. Though the participants were the same group, some participants did not meet the requirements of Pethlert project such as unavailable during study period, did not return the informed consent, the levels of daily alcoholic drinking were exceeded the criteria of non-alcoholic fatty liver. Therefore, the number of Pethlert project is less than Insawang project.
Commercial MSG is always available and is not expensive for villagers to obtain it. Normally, only one person preparing food for family and that is the key person for MSG consumption in the family. We gave enough information to participants including key persons about the use and the objective of MSG measurement. Participants knew that it doesn’t matter how much the MSG left in the provided box, it will belong to them after 10-day of study. Therefore, it is unlikely that individuals use more MSG than usual because it is free.
Nowadays, it becomes a nuclear family in Thailand, including the area of study. Some families do not have children below 10 years old; however, some families have one or two children. Families usually prepare a special meal for young children by avoiding chili, MSG, salty or any spicy ingredients. Thus, it is not suitable to divide the MSG consumption in each family by number of all family members which may include infant, toddler, or pre-school children. Therefore, we excluded children under 10 for more reasonable calculation of individuals MSG consumption.
The association of the median and percentage values of the five criteria of ATP III individually and MSG intake were not observed in our study. This is probably due to the small number in sample size. However, when combined the metabolic disorders as a cluster, the association was found. Every 1-g of MSG intake significantly increased the risk of having metabolic syndrome with the odds ratio of 1.14. In other word, the estimated risk of having metabolic syndrome increased 1.14 fold for each gram of daily MSG consumption. If a person consumed MSG 5 g/day the estimated risk of having metabolic syndrome would be increased 5.7 fold. Therefore, it shall not classify as very week association.
It is barely to find non-MSG users in the area of study. Moreover, it is hard to identify a person with non-MSG user because if he/she eats out or buys food from retailer or restaurant; generally he/she cannot avoid MSG exposure. Therefore, non-MSG users were not included in our study.
Finally, we note that none of the investigators in our paper has any industrial or personal disclosure.
We submit that MSG poses a host risk in susceptible individuals and that further data is needed to define those at risk.
- Insawang T, Selmi C, Cha’on U, Pethlert S, Yongvanit P, Areejitranusorn P, Boonsiri P, Khampitak T, Tangrassameeprasert R, Pinitsoontorn C: Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population. Nutr Metab (Lond). 2012, 9: 50-10.1186/1743-7075-9-50.View ArticleGoogle Scholar
- Collison KS, Makhoul NJ, Inglis A, Al-Johi M, Zaidi MZ, Maqbool Z, Saleh SM, Bakheet R, Mondreal R, Al-Rabiah R: Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory. Physiol Behav. 2010, 99: 334-342. 10.1016/j.physbeh.2009.11.010.View ArticleGoogle Scholar
- Collison KS, Maqbool Z, Saleh SM, Inglis A, Makhoul NJ, Bakheet R, Al-Johi M, Al-Rabiah R, Zaidi MZ, Al-Mohanna FA: Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease. J Lipid Res. 2009, 50: 1521-1537. 10.1194/jlr.M800418-JLR200.View ArticleGoogle Scholar
- Diniz YS, Faine LA, Galhardi CM, Rodrigues HG, Ebaid GX, Burneiko RC, Cicogna AC, Novelli EL: Monosodium glutamate in standard and high-fiber diets: metabolic syndrome and oxidative stress in rats. Nutrition. 2005, 21: 749-755. 10.1016/j.nut.2004.10.013.View ArticleGoogle Scholar
- Furuya DT, Poletto AC, Favaro RR, Martins JO, Zorn TM, Machado UF: Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate-treated obese mice. Metabolism. 2010, 59: 395-399. 10.1016/j.metabol.2009.08.011.View ArticleGoogle Scholar
- Nagata M, Suzuki W, Iizuka S, Tabuchi M, Maruyama H, Takeda S, Aburada M, Miyamo K: Type 2 diabetes meffitus in obese mouse model induced by monosodium glutamate. Exp Anim. 2006, 55: 109-115. 10.1538/expanim.55.109.View ArticleGoogle Scholar
- Zorad S, Macho L, Jezova D, Fickova M: Partial characterization of insulin resistance in adipose tissue of monosodium glutamate-induced obese rats. Ann N Y Acad Sci. 1997, 827: 541-545. 10.1111/j.1749-6632.1997.tb51867.x.View ArticleGoogle Scholar
- Shi Z, Luscombe-Marsh ND, Wittert GA, Yuan B, Dai Y, Pan X, Taylor AW: Monosodium glutamate is not associated with obesity or a greater prevalence of weight gain over 5 years: findings from the jiangsu nutrition study of Chinese adults. Br J Nutr. 2010, 104: 457-463. 10.1017/S0007114510000760.View ArticleGoogle Scholar
- Shi Z, Yuan B, Taylor AW, Dai Y, Pan X, Gill TK, Wittert GA: Monosodium glutamate is related to a higher increase in blood pressure over 5 years: findings from the jiangsu nutrition study of Chinese adults. J Hypertens. 2011, 29: 846-853. 10.1097/HJH.0b013e328344da8e.View ArticleGoogle Scholar
- Pethlert S, Insawang T, Boonnate P, Tangrassameeprasert R, Khampitak T, Prasongwattana V, Cha’on U: Monosodium glutamate consumption and parameters of liver injury in humans. Srinagarind Med J. 2011, 26 (Suppl): 233-235.Google Scholar
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