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Figure 5 | Nutrition & Metabolism

Figure 5

From: Supplementation of carnitine leads to an activation of the IGF-1/PI3K/Akt signalling pathway and down regulates the E3 ligase MuRF1 in skeletal muscle of rats

Figure 5

Relative protein concentrations of total and phosphorylated mTOR at Ser2448and Ser2481and calculated phospho-mTOR (Ser2448)/total mTOR and phosphor-mTOR (Ser2481)/total mTOR ratios in M. quadriceps femoris of rats fed either a control diet (0 mg carnitine/ kg diet; Control) or a diet supplemented with 1250 mg carnitine/ kg diet (Carnitine) . (A) Representative immunoblots specific to total mTOR, phosphor-mTOR (Ser2448), phosphor-mTOR (Ser2481) and α-Tubulin as internal control are shown for one animal per group; immunoblots for the other animals revealed similar results. (B) Bars represent data from densitometric analysis and represent means ± SD (n = 6/group); bars are expressed relative to the protein level of the control group (= 1.00). * indicates a significant difference to the control group (P < 0.05).

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Nutrition & Metabolism

ISSN: 1743-7075

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