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Table 2 Birth Weight, Weaning Weight, and Adult Weight

From: Insulin sensitivity is normalized in the third generation (F3) offspring of developmentally programmed insulin resistant (F2) rats fed an energy-restricted diet

Males Birth Weight (g) Weaning Weight (g) 75 d Weight (g)
Controls (10) 7.1 ± 0.4 a 68.7 ± 1.4 a 449.0 ± 8.8 a
F1 (7) 5.1 ± 0.1 b 23.9 ± 1.7 b 257.4 ± 11.5 b
F2 (7) 6.6 ± 0.2 ac 29.0 ± 0.8 c 276.4 ± 16.2 b
F3.1 (7) 5.8 ± 0.2 bc 29.1 ± 0.9 c 250.0 ± 6.5 b
F3.2 (7) 6.6 ± 0.3 ac 31.9 ± 0.8 c 337.0 ± 9.4 c
Females    
Controls (3) 7.7 ± 0.9 a 60.0 ± 1.7 a 261.3 ± 3.2 a
F1 (7) 5.3 ± 0.3 b 26.3 ± 1.0 bc 173.7 ± 7.1 b
F2 (3) 7.0 ± 0.0 ac 29.3 ± 0.3 c 187.7 ± 8.8 b
F3.1 (6) 6.0 ± 0.3 bc 26.0 ± 0.9 b 182.8 ± 5.5 b
F3.2 (5) 6.4 ±0.2 c 28.8 ± 0.7 c 223.6 ± 2.3 c
  1. Mean birth weights, 14 d weaning weights, and 75 d weights for control rats and rats whose dams consumed low-protein diets while pregnant and nursing (F1), offspring of F1 rats (F2); and, offspring of F2 rats (F3.1 and F3.2). Control rat dams consumed adequate diets ad libitum during pregnancy and while nursing, and control offspring consumed adequate diets ad libitum postweaning. All F1, F2 and F3 offspring were fed nutritionally adequate but energy-restricted diets (70% of control ad libitum consumption) postweaning with the exception of the F3.2 offspring that were fed the control diet ad libitum. (Sample size shown in parentheses.) Means (± SE) in columns with different letters differ significantly (p < 0.05, significant univariate ANOVA with LSD post-hoc analysis).