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Figure 2 | Nutrition & Metabolism

Figure 2

From: Lifestyle-induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe?

Figure 2

The tipping point and the metabolic syndrome. Without hormesis, and in the presence of excess calories, VAT can build up, which is associated with excessive ectopic fat due to metabolic inflexibility. This is associated with rising oxidative stress and a shift from thrifty to inflammatory insulin resistance; this results in the metabolic syndrome and an accelerated ageing phenotype.

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