| |
Control
|
Low Resveratrol1
|
High Resveratrol2
|
Low HMB3
|
Low Resv/Low HMB
|
Low Resv/High HMB4
|
Low Resv/Leucine5
|
P value
|
|---|
|
C-reactive protein (ng/mL)
|
95.6 ± 9.6a
|
134.8 ± 8.5a
|
123.9 ± 35.3a
|
98.6 ± 5.1a
|
67.4 ± 12.2b
|
58.3 ± 12.4b
|
55.9 ± 17.7b
|
P < 0.01
|
|
IL-6 (pg/mL)
|
29.0 ± 6.4a
|
23.2 ± 2.9a
|
14.1 ± 1.3b
|
19.9 ± 3.1a
|
6.9 ± 1.2c
|
4.5 ± 2.6c
|
11.2 ± 4.1b
|
P < 0.005
|
|
MCP-1 (pg/mL)
|
115.8 ± 19.7a
|
104.4 ± 16.5a
|
27.3 ± 6.8b
|
116.8 ± 9.3a
|
24.2 ± 6.2b
|
15.2 ± 3.7b
|
34.9 ± 5.9b
|
P < 0.001
|
|
Adiponectin (ng/mL)
|
11.0 ± 0.9a
|
12.4 ± 1.1a
|
14.8 ± 1.8b
|
11.1 ± 1.6a
|
14.1 ± 0.8b
|
16.3 ± 3.0b
|
14.5 ± 1.0b
|
P < 0.03
|
- Mice were fed a high fat-diet with indicated treatments for 6 weeks. At the end of the treatment period, oxidative and inflammatory stress biomarkers in plasma were determined. Data are presented as means ± SE (n = 10). Non-matching letter superscripts in each row denote significant differences at the indicated p value.
- 1Low resveratrol: 12.5 mg resveratrol/kg diet.
- 2High resveratrol: 225 mg resveratrol/kg diet.
- 3Low HMB: 2 g hyroxymethylbutyrate (calcium salt).
- 4High HMB: 10 g hyroxymethylbutyrate (calcium salt).
- 5Leucine: 24 g leucine/kg diet.
