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Table 2 6-min walk test at baseline and at end of the study for all participants

From: Efficacy of a novel formulation of L-Carnitine, creatine, and leucine on lean body mass and functional muscle strength in healthy older adults: a randomized, double-blind placebo-controlled study

 

L-Carnitine-combination

L-Carnitine

Placebo

P ValueΔ

P Value¤

Mean + SD (n)

Within Group P Value

Mean + SD (n)

Within Group P Value

Mean + SD (n)

Within Group P Value

Meters Walked in Six Minutes (m)

 Baseline (Week 0)

432 ± 109 (14)

458 ± 127 (11)

526 ± 80 (14)

–

–

 Visit 2 (Week 8)

462 ± 113 (14)

444 ± 119 (11)

530 ± 100 (14)

–

–

 Change from Baseline to Week 8

30 ± 70 (14)

P = 0.126

−14 ± 107 (11)

P = 0.617

3 ± 69 (14)

P = 0.704

0. 292

0.856

Out of Breath Score Before Walking

 Baseline (Week 0)

0.21 ± 0.80 (14)

0.091 ± 0.302 (11)

0.00 ± 0.00 (14)

–

–

 Visit 2 (Week 8)

0.036 ± 0.134 (14)

0.045 ± 0.151 (11)

0.000 ± 0.000 (14)

–

–

 Change from Baseline to Week 8

−0.18 ± 0.67 (14)

P = 1.000‡

−0.14 ± 0.64 (11)

P = 0.590‡

0.00 ± 0.00 (14)

P = 1.000‡

0. 295

0.353

Out of Breath Score After Walking

 Baseline (Week 0)

1.07 ± 2.16 (14)

0.55 ± 0.79 (11)

1.04 ± 0.91 (14)

–

–

 Visit 2 (Week 8)

1.00 ± 1.79 (14)

0.41 ± 0.58 (11)

0.61 ± 0.56 (14)

–

–

 Change from Baseline to Week 8

−0.07 ± 0.87 (14)

P = 0.730‡

−0.14 ± 0.64 (11)

P = 0.590‡

−0.43 ± 0.70 (14)

P =  0.044‡

0. 234

0.222

Change in Out of Breath Score After Walking

 Baseline (Week 0)

0.86 ± 1.60 (14)

0.45 ± 0.65 (11)

1.04 ± 0.91 (14)

–

–

 Visit 2 (Week 8)

0.96 ± 1.70 (14)

0.36 ± 0.45 (11)

0.61 ± 0.56 (14)

–

–

 Change from Baseline to Week 8

0.11 ± 0.68 (14)

P = 0.792‡

−0.09 ± 0.66 (11)

P = 0.792‡

−0.43 ± 0.70 (14)

P =  0.044‡

0. 175

0.069

Fatigue Score Before Walking

 Baseline (Week 0)

0.21 ± 0.54 (14)

0.50 ± 1.02 (11)

0.54 ± 0.93 (14)

–

–

 Visit 2 (Week 8)

0.25 ± 0.80 (14)

0.18 ± 0.60 (11)

0.39 ± 0.92 (14)

–

–

 Change from Baseline to Week 8

0.04 ± 0.95 (14)

P = 0.854‡

−0.32 ± 1.27 (11)

P = 0.461‡

−0.14 ± 0.57 (14)

P = 0.387‡

0. 853

0.893

Fatigue Score After Walking

 Baseline (Week 0)

0.64 ± 1.36 (14)

0.82 ± 1.03 (11)

0.82 ± 0.91 (14)

–

–

 Visit 2 (Week 8)

0.93 ± 1.25 (14)

0.45 ± 0.88 (11)

0.61 ± 0.86 (14)

–

–

 Change from Baseline to Week 8

0.29 ± 1.17 (14)

P = 0.394‡

−0.36 ± 1.38 (11)

P = 0.348‡

−0.21 ± 0.64 (14)

P = 0.266‡

0. 800

0.154

Change in Fatigue Score After Walking

 Baseline (Week 0)

0.43 ± 1.33 (14)

0.32 ± 0.64 (11)

0.29 ± 0.64 (14)

–

–

 Visit 2 (Week 8)

0.68 ± 1.05 (14)

0.273 ± 0.344 (11)

0.21 ± 0.26 (14)

–

–

 Change from Baseline to Week 8

0.25 ± 1.03 (14)

P = 0.341‡

−0.05 ± 0.65 (11)

P = 1.000‡

−0.07 ± 0.68 (14)

P = 0.660‡

0. 729

0.201

  1. N number, SD standard deviation
  2. ΔBetween-group comparisons for placebo and L-Carnitine were made using the Mann-Whitney U test
  3. ¤Between-group comparisons for placebo and L-Carnitine-Combination were made using the Mann-Whitney U test
  4. ‡Within-group comparisons were made using the signed-rank test
  5. Probability values P ≤ 0.05 are statistically significant
  6. The bold data represents a significant P value (P>0.05)
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Nutrition & Metabolism

ISSN: 1743-7075

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