Salivary proline-rich protein may reduce tannin-iron chelation: a systematic narrative review

Tannins are often cited for antinutritional effects, including chelation of non-heme iron. Despite this, studies exploring non-heme iron bioavailability inhibition with long-term consumption have reported mixe...

Authors: Nicole M. Delimont, Sara K. Rosenkranz, Mark D. Haub and Brian L. Lindshield

Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

Diabetic patients are at an increased risk of developing heart failure when compared to their non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be central in the development o...

Authors: Phiwayinkosi V. Dludla, Elizabeth Joubert, Christo J.F. Muller, Johan Louw and Rabia Johnson

Positive association between musclin and insulin resistance in obesity: evidence of a human study and an animal experiment

Musclin is a novel skeletal muscle-derived secretory factor considered to be a potent regulator of the glucose metabolism and therefore may contribute to the pathogenesis of obesity and insulin resistance (IR).

Authors: Wen-Jia Chen, Yue Liu, Yu-Bin Sui, Hong-Tao Yang, Jin-Rui Chang, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang and Xin-Hua Yin

Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism

We sought to characterize the effects of dietary macronutrient composition on various hormones implicated in the regulation of insulin sensitivity (IS) and energy expenditure (EE).

Authors: Bridget M. Hron, Cara B. Ebbeling, Henry A. Feldman and David S. Ludwig

Piperine enhances carbohydrate/fat metabolism in skeletal muscle during acute exercise in mice

Exercise promotes energy metabolism (e.g., metabolism of glucose and lipids) in skeletal muscles; however, reactive oxygen species are also generated during exercise. Various spices have been reported to have ...

Authors: Jisu Kim, Kang-Pa Lee, Dae-Won Lee and Kiwon Lim

Discrepancies in publications related to HMB-FA and ATP supplementation

This letter addresses a number of discrepancies found in several publications related HMB-FA and ATP supplementation.

Authors: Jeremy A. Gentles and Stuart M. Phillips

Free fatty acids and cardiovascular outcome: a Chinese cohort study on stable coronary artery disease

Studies have revealed that plasma level of free fatty acids (FFAs) is related to cardiovascular disease. However, the role of FFAs in clinical outcomes of stable coronary artery disease (SCAD) has been less ev...

Authors: Hui-Wen Zhang, Xi Zhao, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Jing Sun, Geng Liu, Qian Dong and Jian-Jun Li

Erratum to: Evaluation of Lactobacillus coryniformis CECT5711 strain as a coadjuvant in a vaccination process: a randomised clinical trial in healthy adults

Authors: Noemí Redondo, Esther Nova, Alina Gheorghe, Ligia Esperanza Díaz, Aurora Hernández and Ascensión Marcos

Erratum to: Evaluation of Lactobacillus coryniformis CECT5711 strain as a coadjuvant in a vaccination process: a randomised clinical trial in healthy adults

Authors: Noemí Redondo, Esther Nova, Alina Gheorghe, Ligia Esperanza Díaz, Aurora Hernández and Ascensión Marcos

Cichorium intybus L. promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia

Excessive production and/or reduced excretion of uric acid could lead to hyperuricemia, which could be a major cause of disability. Hyperuricemia has received increasing attention in the last few decades due t...

Authors: Yu Wang, Zhijian Lin, Bing Zhang, Anzheng Nie and Meng Bian

Supramolecular structure of dietary fat in early life modulates expression of markers for mitochondrial content and capacity in adipose tissue of adult mice

Previous studies have shown that early life nutrition can modulate the development of white adipose tissue and thereby affect the risk on obesity and metabolic disease later in life. For instance, postnatal fe...

Authors: Andrea Kodde, Eline M. van der Beek, Esther Phielix, Eefje Engels, Lidewij Schipper and Annemarie Oosting

The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults: an exploratory study

Inflammation is associated with increased bone resorption; the role of inflammation in postprandial bone turnover has not been explored. Consumption of milk fat globule membrane (MFGM) reduces inflammation in ...

Authors: Tara S. Rogers, Elieke Demmer, Nancy Rivera, Erik R. Gertz, J. Bruce German, Jennifer T. Smilowitz, Angela M. Zivkovic and Marta D. Van Loan

Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle

Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation ...

Authors: Ted G. Graber, Michael S. Borack, Paul T. Reidy, Elena Volpi and Blake B. Rasmussen

Association of adipokines with blood pressure, arterial elasticity and cardiac markers in dialysis patients: cross-sectional analysis of baseline data from a cohort study

Adipokines are a set of cytokines secreted by white adipose tissue that have been suggested to be involved in the development of cardiovascular diseases. We aimed to evaluate the cross-sectional associations o...

Authors: Wenjin Liu, Lei Jiang, Jianping Chen, Chaoqing Gao, Jianmei Zhou, Jiajun Zhou, Youwei Bai, Hong Chu, Wei Fan, Liang Wang, Zhuxing Sun, Xiurong Li and Junwei Yang

Impact of 8-week linoleic acid intake in soy oil on Lp-PLA₂ activity in healthy adults

No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A₂ (Lp-PLA₂), which is a risk factor for cardiovascular...

Authors: Minkyung Kim, Minjoo Kim, Ayoung Lee, Hye Jin Yoo, Jung Soo Her, Sun Ha Jee and Jong Ho Lee

Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice

Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrop...

Authors: Hodaka Yamada, Tomio Umemoto, Masafumi Kakei, Shin-ichi Momomura, Masanobu Kawakami, San-e Ishikawa and Kazuo Hara

Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats

Ketosis can be induced in humans and in animals by fasting or dietary interventions, such as ketogenic diets. However, the increasing interest on the ketogenic state has motivated the development of alternativ...

Authors: Rennan de Oliveira Caminhotto, Ayumi Cristina Medeiros Komino, Flaviane de Fatima Silva, Sandra Andreotti, Rogério Antônio Laurato Sertié, Gabriela Boltes Reis and Fabio Bessa Lima

Resveratrol regulates body weight in healthy and ovariectomized rats

The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of t...

Authors: Rupali Sharma, Neel Kamal Sharma and M. Thungapathra

The function of myostatin in the regulation of fat mass in mammals

Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mu...

Authors: Bing Deng, Feng Zhang, Jianghui Wen, Shengqiang Ye, Lixia Wang, Yu Yang, Ping Gong and Siwen Jiang

Dynamic and temporal assessment of human dried blood spot MS/MS^ALL shotgun lipidomics analysis

Real-time and dynamic assessment of an individual’s lipid homeostatic state in blood is complicated due to the need to collect samples in a clinical environment. In the context of precision medicine and popula...

Authors: Fei Gao, Justice McDaniel, Emily Y. Chen, Hannah E. Rockwell, Jeremy Drolet, Vivek K. Vishnudas, Vladimir Tolstikov, Rangaprasad Sarangarajan, Niven R. Narain and Michael A. Kiebish

Vitamin D: a possible modifying factor linking obesity to vascular calcification in hemodialysis patients

Obesity is a risk factor for increased cardiovascular disease. Whether vitamin D deficiency modifies this association is unclear. Here, we examined the association of obesity and vitamin D deficiency with vasc...

Authors: Jwa-Kyung Kim, Mi Jin Park, Young Rim Song, Hyung Jik Kim and Sung Gyun Kim

A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?

Vitamin D insufficiency (serum 25-OH vitamin D > 10 ng/ml and < 30 ng/ml) is prevalent in the obese (body mass index (BMI) > 30 kg/m2), yet relationships between the two are poorly understood. Objectives of this ...

Authors: Kenneth L. Seldeen, Manhui Pang, Maria Rodríguez-Gonzalez, Mireya Hernandez, Zachary Sheridan, Ping Yu and Bruce R. Troen

Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States

This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9–13 years.

Authors: Kelly Virecoulon Giudici, Joseph M. Kindler, Berdine R. Martin, Emma M. Laing, George P. McCabe, Linda D. McCabe, Dorothy B. Hausman, Lígia Araújo Martini, Richard D. Lewis, Connie M. Weaver, Munro Peacock and Kathleen M. Hill Gallant

Resistance training to improve type 2 diabetes: working toward a prescription for the future

The prevalence of type 2 diabetes (T2D) is rapidly increasing, and effective strategies to manage and prevent this disease are urgently needed. Resistance training (RT) promotes health benefits through increas...

Authors: Dominik H. Pesta, Renata L. S. Goncalves, Anila K. Madiraju, Barbara Strasser and Lauren M. Sparks

Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring

The mother’s consumption of high-fat food can affect glucose metabolism and the hypothalamic–pituitary–adrenal axis responsiveness in the offspring and potentially affect the metabolic responses to stress as w...

Authors: Roxana Karbaschi, Homeira Zardooz, Fariba Khodagholi, Leila Dargahi, Mina Salimi and FatemehSadat Rashidi