Free fatty acids and cardiovascular outcome: a Chinese cohort study on stable coronary artery disease

Studies have revealed that plasma level of free fatty acids (FFAs) is related to cardiovascular disease. However, the role of FFAs in clinical outcomes of stable coronary artery disease (SCAD) has been less ev...

Authors: Hui-Wen Zhang, Xi Zhao, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Jing Sun, Geng Liu, Qian Dong and Jian-Jun Li

Erratum to: Evaluation of Lactobacillus coryniformis CECT5711 strain as a coadjuvant in a vaccination process: a randomised clinical trial in healthy adults

Authors: Noemí Redondo, Esther Nova, Alina Gheorghe, Ligia Esperanza Díaz, Aurora Hernández and Ascensión Marcos

Erratum to: Evaluation of Lactobacillus coryniformis CECT5711 strain as a coadjuvant in a vaccination process: a randomised clinical trial in healthy adults

Authors: Noemí Redondo, Esther Nova, Alina Gheorghe, Ligia Esperanza Díaz, Aurora Hernández and Ascensión Marcos

Cichorium intybus L. promotes intestinal uric acid excretion by modulating ABCG2 in experimental hyperuricemia

Excessive production and/or reduced excretion of uric acid could lead to hyperuricemia, which could be a major cause of disability. Hyperuricemia has received increasing attention in the last few decades due t...

Authors: Yu Wang, Zhijian Lin, Bing Zhang, Anzheng Nie and Meng Bian

Supramolecular structure of dietary fat in early life modulates expression of markers for mitochondrial content and capacity in adipose tissue of adult mice

Previous studies have shown that early life nutrition can modulate the development of white adipose tissue and thereby affect the risk on obesity and metabolic disease later in life. For instance, postnatal fe...

Authors: Andrea Kodde, Eline M. van der Beek, Esther Phielix, Eefje Engels, Lidewij Schipper and Annemarie Oosting

The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults: an exploratory study

Inflammation is associated with increased bone resorption; the role of inflammation in postprandial bone turnover has not been explored. Consumption of milk fat globule membrane (MFGM) reduces inflammation in ...

Authors: Tara S. Rogers, Elieke Demmer, Nancy Rivera, Erik R. Gertz, J. Bruce German, Jennifer T. Smilowitz, Angela M. Zivkovic and Marta D. Van Loan

Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle

Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation ...

Authors: Ted G. Graber, Michael S. Borack, Paul T. Reidy, Elena Volpi and Blake B. Rasmussen

Association of adipokines with blood pressure, arterial elasticity and cardiac markers in dialysis patients: cross-sectional analysis of baseline data from a cohort study

Adipokines are a set of cytokines secreted by white adipose tissue that have been suggested to be involved in the development of cardiovascular diseases. We aimed to evaluate the cross-sectional associations o...

Authors: Wenjin Liu, Lei Jiang, Jianping Chen, Chaoqing Gao, Jianmei Zhou, Jiajun Zhou, Youwei Bai, Hong Chu, Wei Fan, Liang Wang, Zhuxing Sun, Xiurong Li and Junwei Yang

Impact of 8-week linoleic acid intake in soy oil on Lp-PLA₂ activity in healthy adults

No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A₂ (Lp-PLA₂), which is a risk factor for cardiovascular...

Authors: Minkyung Kim, Minjoo Kim, Ayoung Lee, Hye Jin Yoo, Jung Soo Her, Sun Ha Jee and Jong Ho Lee

Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice

Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrop...

Authors: Hodaka Yamada, Tomio Umemoto, Masafumi Kakei, Shin-ichi Momomura, Masanobu Kawakami, San-e Ishikawa and Kazuo Hara

Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats

Ketosis can be induced in humans and in animals by fasting or dietary interventions, such as ketogenic diets. However, the increasing interest on the ketogenic state has motivated the development of alternativ...

Authors: Rennan de Oliveira Caminhotto, Ayumi Cristina Medeiros Komino, Flaviane de Fatima Silva, Sandra Andreotti, Rogério Antônio Laurato Sertié, Gabriela Boltes Reis and Fabio Bessa Lima

Resveratrol regulates body weight in healthy and ovariectomized rats

The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of t...

Authors: Rupali Sharma, Neel Kamal Sharma and M. Thungapathra

The function of myostatin in the regulation of fat mass in mammals

Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mu...

Authors: Bing Deng, Feng Zhang, Jianghui Wen, Shengqiang Ye, Lixia Wang, Yu Yang, Ping Gong and Siwen Jiang

Dynamic and temporal assessment of human dried blood spot MS/MS^ALL shotgun lipidomics analysis

Real-time and dynamic assessment of an individual’s lipid homeostatic state in blood is complicated due to the need to collect samples in a clinical environment. In the context of precision medicine and popula...

Authors: Fei Gao, Justice McDaniel, Emily Y. Chen, Hannah E. Rockwell, Jeremy Drolet, Vivek K. Vishnudas, Vladimir Tolstikov, Rangaprasad Sarangarajan, Niven R. Narain and Michael A. Kiebish

Vitamin D: a possible modifying factor linking obesity to vascular calcification in hemodialysis patients

Obesity is a risk factor for increased cardiovascular disease. Whether vitamin D deficiency modifies this association is unclear. Here, we examined the association of obesity and vitamin D deficiency with vasc...

Authors: Jwa-Kyung Kim, Mi Jin Park, Young Rim Song, Hyung Jik Kim and Sung Gyun Kim

A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?

Vitamin D insufficiency (serum 25-OH vitamin D > 10 ng/ml and < 30 ng/ml) is prevalent in the obese (body mass index (BMI) > 30 kg/m2), yet relationships between the two are poorly understood. Objectives of this ...

Authors: Kenneth L. Seldeen, Manhui Pang, Maria Rodríguez-Gonzalez, Mireya Hernandez, Zachary Sheridan, Ping Yu and Bruce R. Troen

Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States

This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9–13 years.

Authors: Kelly Virecoulon Giudici, Joseph M. Kindler, Berdine R. Martin, Emma M. Laing, George P. McCabe, Linda D. McCabe, Dorothy B. Hausman, Lígia Araújo Martini, Richard D. Lewis, Connie M. Weaver, Munro Peacock and Kathleen M. Hill Gallant

Resistance training to improve type 2 diabetes: working toward a prescription for the future

The prevalence of type 2 diabetes (T2D) is rapidly increasing, and effective strategies to manage and prevent this disease are urgently needed. Resistance training (RT) promotes health benefits through increas...

Authors: Dominik H. Pesta, Renata L. S. Goncalves, Anila K. Madiraju, Barbara Strasser and Lauren M. Sparks

Case-control study of metabolic syndrome and ovarian cancer in Chinese population

Recent studies have proved metabolic syndrome (MetS) was linked to cancer risks. However, few data has examined the relationship between MetS and epithelial ovarian cancer (EOC).

Authors: Ying Chen, Lei Zhang, Wenxin Liu and Ke Wang

Potential therapeutic targets of Guggulsterone in cancer

Natural compounds capable of inducing apoptosis in cancer cells have always been of considerable interest as potential anti-cancer agents. Many such compounds are under screening and development with their pot...

Authors: Ajaz A. Bhat, Kirti S. Prabhu, Shilpa Kuttikrishnan, Roopesh Krishnankutty, Jayaprakash Babu, Ramzi M. Mohammad and Shahab Uddin

Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage

Dietary salts are important factors in metabolic disorders. They are vital components of enzymes, vitamins, hormones, and signal transduction that act synergistically to regulate lipid metabolism. Our previous...

Authors: Jun Ling, Christopher Brey, Megan Schilling, Farah Lateef, Zenaida P. Lopez-Dee, Kristopher Fernandes, Kavita Thiruchelvam, Yi Wang, Kshitij Chandel, Kai Rau, Ranjit Parhar, Futwan Al-Mohanna, Randy Gaugler and Sarwar Hashmi

Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring

The mother’s consumption of high-fat food can affect glucose metabolism and the hypothalamic–pituitary–adrenal axis responsiveness in the offspring and potentially affect the metabolic responses to stress as w...

Authors: Roxana Karbaschi, Homeira Zardooz, Fariba Khodagholi, Leila Dargahi, Mina Salimi and FatemehSadat Rashidi

Press-pulse: a novel therapeutic strategy for the metabolic management of cancer

A shift from respiration to fermentation is a common metabolic hallmark of cancer cells. As a result, glucose and glutamine become the prime fuels for driving the dysregulated growth of tumors. The simultaneou...

Authors: Thomas N. Seyfried, George Yu, Joseph C. Maroon and Dominic P. D’Agostino

Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet

Nutritional status in early life is critically involved in the metabolic phenotype of offspring. However the changes triggered by maternal consumption of high-fat diet (HFD) in pre- or postnatal period should ...

Authors: Laís Angélica de Paula Simino, Thaís de Fante, Marina Figueiredo Fontana, Fernanda Oliveira Borges, Márcio Alberto Torsoni, Marciane Milanski, Lício Augusto Velloso and Adriana Souza Torsoni

Long-term intake of saccharin decreases post-absortive energy expenditure at rest and is associated to greater weight gain relative to sucrose in wistar rats

Non-nutritive sweeteners (NNS) have been associated with increased prevalence of obesity. In previous studies, we demonstrated that saccharin could induce an increase in weight gain either when compared to suc...

Authors: Denise Entrudo Pinto, Kelly Carraro Foletto, Ramiro Barcos Nunes, Pedro Dal Lago and Marcello Casaccia Bertoluci