Articles

Metabolomics insights into the modulatory effects of long-term compound polysaccharide intake in high-fat diet-induced obese rats

Polysaccharides can alleviate obesity in mammals; however, studies on mechanism of this alleviation are limited. A few studies have indicated that polysaccharides improve obesity by regulating the metabolism o...

Authors: Mingyi Chen, Biyu Lu, Yuan Li, Yuanyuan Wang, Haihui Zheng, Danmin Zhong, Ziqiong Liao, Mengxia Wang, Fangli Ma, Qiongfeng Liao and Zhiyong Xie

The interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A metabolism

Selenoprotein F (SELENOF, was named as 15-kDa selenoprotein) has been reported to play important roles in oxidative stress, endoplasmic reticulum (ER) stress and carcinogenesis. However, the biological functio...

Authors: Jing Tian, Jiapan Liu, Jieqiong Li, Jingxin Zheng, Lifang Chen, Yujuan Wang, Qiong Liu and Jiazuan Ni

Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities

Ageing is a nonmodifiable risk factor that is linked to increased likelihood of cardiovascular morbidities. Whilst many pharmacological interventions currently exist to treat many of these disorders such as st...

Authors: Nardev Ramanathan, Esther Tan, Li Jun Loh, Boon Seng Soh and Wei Ney Yap

Estimated dietary iodine intake as a predictor of placental size: evidence from the ELSPAC study

The relationship between low iodine status and pregnancy-associated comorbidities has been known for decades. The relationship between iodine intake and placental pathologies is, however, far less clear. This ...

Authors: Julie Bienertová-Vašků, Markéta Grulichová, Ondřej Mikeš, Filip Zlámal, Tomáš Pruša, Aneta Pohořalá, Lenka Andrýsková and Hynek Pikhart

Z-ligustilide and anti-inflammatory prostaglandins have common biological properties in macrophages and leukocytes

During inflammation, immune cells produce cytokines, chemokines and prostaglandins. This results in acute or chronic inflammation, which favor the development of degenerative diseases such as diabetes, obesity...

Authors: Joseph Schwager, Lidia Gagno, Nathalie Richard, Werner Simon, Peter Weber and Igor Bendik

The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: the fiber factor

Diets used to induce metabolic disease are generally high in fat and refined carbohydrates and importantly, are usually made with refined, purified ingredients. However, researchers will often use a low fat gr...

Authors: Michael A. Pellizzon and Matthew R. Ricci

The carnitine status does not affect the contractile and metabolic phenotype of skeletal muscle in pigs

Recently, supplementation of L-carnitine to obese rats was found to improve the carnitine status and to counteract an obesity-induced muscle fiber transition from type I to type II. However, it has not been re...

Authors: Daniel Kaup, Janine Keller, Erika Most, Joachim Geyer, Klaus Eder and Robert Ringseis

Association of sleep duration with apolipoproteins and the apolipoprotein B/A1 ratio: the China health and nutrition survey

Short sleep duration has been related to established cardiovascular risk factors, likely obesity, diabetes, hypertension and dyslipidaemia. However, to the best of our knowledge, the associations between sleep...

Authors: Huihui Ren, Zhelong Liu, Xinrong Zhou and Gang Yuan

The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes

This study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM)...

Authors: Maryamalsadat Razavi, Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Mohsen Taghizadeh, Reza Bekhradi, Elahe Seyed Hosseini, Hamed Haddad Kashani, Maryam Karamali and Zatollah Asemi

Ascorbic acid promotes 3T3-L1 cells adipogenesis by attenuating ERK signaling to upregulate the collagen VI

Type VI collagen is supposed to be a regulation factor in adipogenesis. This study aimed to assess the promoting effect of vitamin C (VC) on adipogenic differentiation of preadipocytes as well as its mechanism.

Authors: Chuanguo Liu, Kun Huang, Guorong Li, Pingping Wang, Chang Liu, Congcong Guo, Zongguo Sun and Jie Pan

The metabolism and significance of homocysteine in nutrition and health

An association between arteriosclerosis and homocysteine (Hcy) was first demonstrated in 1969. Hcy is a sulfur containing amino acid derived from the essential amino acid methionine (Met). Hyperhomocysteinemia...

Authors: Avinash Kumar, Henry A. Palfrey, Rashmi Pathak, Philip J. Kadowitz, Thomas W. Gettys and Subramanyam N. Murthy

Genetic variations of cholesteryl ester transfer protein and diet interactions in relation to lipid profiles and coronary heart disease: a systematic review

Data on diet–genotype interactions in the prevention or treatment of dyslipidemia have increased remarkably. This systematic review aimed to assess nutrigenetic studies regarding the modulating effect of diet ...

Authors: Parvin Mirmiran, Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Gelareh Koochakpoor, Maryam S. Daneshpour, Bahar Sedaghati-Khayat and Fereidoun Azizi

Correction to: Antiobesity potential of Piperonal: promising modulation of body composition, lipid profiles and obesogenic marker expression in HFD-induced obese rats

Following publication of the original article [1], the authors requested a correction to the name of one of the co-authors. The correct name and spelling is V.V. Sathibabu Uddandrao.

Authors: Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy and V. V. Sathibabu Uddandrao

Retroconversion is a minor contributor to increases in eicosapentaenoic acid following docosahexaenoic acid feeding as determined by compound specific isotope analysis in rat liver

Dietary docosahexaenoic acid (DHA, 22:6n-3) not only increases blood and tissue levels of DHA, but also eicosapentaenoic acid (EPA, 20:5n-3). It is generally believed that this increase is due to DHA retroconv...

Authors: Adam H. Metherel, Raphaël Chouinard-Watkins, Marc-Olivier Trépanier, R. J. Scott Lacombe and Richard P. Bazinet

Response to discrepancies in publications related to HMB-FA and ATP supplementation

Gentles and Phillips have submitted questions regarding three recent papers investigating ATP, HMB and the combination. The questions pertaining to the homogeneity of subjects’ characteristics between the thre...

Authors: Jacob M Wilson

Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis

The present analysis was designed to investigate the association of type 2 diabetes (T2D) with high sensitivity cardiac troponin T (hs-cTnT) during the 5 years of follow-up, and explore which one of fasting bl...

Authors: Shihui Fu, Rongjie Jin, Leiming Luo and Ping Ye

Antiobesity potential of Piperonal: promising modulation of body composition, lipid profiles and obesogenic marker expression in HFD-induced obese rats

Black pepper or Piper nigrum is a well-known spice, rich in a variety of bioactive compounds, and widely used in many cuisines across the world. In the Indian traditional systems of medicine, it is used to treat ...

Authors: Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy and V. V. Sathibabu Uddandrao

An excess dietary vitamin E concentration does not influence Nrf2 signaling in the liver of rats fed either soybean oil or salmon oil

Reactive oxygen species (ROS) are known to stimulate the activation of nuclear factor-erythroid 2-related factor-2 (Nrf2), the key regulator of the antioxidant and cytoprotective defense system in the body. Th...

Authors: Klaus Eder, Marina Siebers, Erika Most, Susan Scheibe, Norbert Weissmann and Denise K. Gessner

Total energy expenditure of 10- to 12-year-old Japanese children measured using the doubly labeled water method

To establish Japanese children’s estimated energy requirements, total energy expenditure (TEE) data measured using the doubly labeled water (DLW) method is needed. This study aimed to 1) obtain basic TEE data ...

Authors: Keisuke Komura, Satoshi Nakae, Kazufumi Hirakawa, Naoyuki Ebine, Kazuhiro Suzuki, Haruo Ozawa, Yosuke Yamada, Misaka Kimura and Kojiro Ishii

Does the enterolactone (ENL) affect fatty acid transporters and lipid metabolism in liver?

NAFLD as a result of inappropriate diet and obesity, may progress to sever conditions such as: type 2 diabetes mellitus or steatohepatitis, and has recently become a prevalent topic of numerous investigations....

Authors: Krzysztof Drygalski, Klaudia Berk, Tomasz Charytoniuk, Nicoletta Iłowska, Bartłomiej Łukaszuk, Adrian Chabowski and Karolina Konstantynowicz-Nowicka

Folic acid prevents cardiac dysfunction and reduces myocardial fibrosis in a mouse model of high-fat diet-induced obesity

Folic acid (FA) is an antioxidant that can reduce reactive oxygen species generation and can blunt cardiac dysfunction during ischemia. We hypothesized that FA supplementation prevents cardiac fibrosis and car...

Authors: Wei Li, Renqiao Tang, Shengrong Ouyang, Feifei Ma, Zhuo Liu and Jianxin Wu

Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats

This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of second-generation of offspring (F2).

Authors: Yan-Hong Huang, Ting-Ting Ye, Chong-Xiao Liu, Lei Wang, Yuan-Wen Chen and Yan Dong

Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine

High-fat (HF) diet is a well-known cause of obesity. To identify principle transcriptional regulators that could be therapeutic targets of obesity, we investigated transcriptomic modulation in the duodenal muc...

Authors: Octave Mucunguzi, Aicha Melouane, Abdelaziz Ghanemi, Mayumi Yoshioka, André Boivin, Ezequiel-Luis Calvo and Jonny St-Amand

Postprandial low-grade inflammation does not specifically require TLR4 activation in the rat

Toll-like receptor 4 (TLR4), an innate immune receptor, is suspected to play a key role in the postprandial inflammation that is induced by a high-fat meal rich in saturated fatty acids (SFA). Our objective wa...

Authors: Dominique Hermier, Véronique Mathé, Annaïg Lan, Clélia Santini, Annie Quignard-Boulangé, Jean-François Huneau and François Mariotti

Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population

The alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio is reportedly associated with insulin resistance (IR). However, few studies have explored the relationship between the ALT/AST ratio an...

Authors: Li Zhao, Jing Cheng, Yingchao Chen, Qin Li, Bing Han, Yi Chen, Fangzhen Xia, Chi Chen, Dongping Lin, Xuemei Yu, Ningjian Wang and Yingli Lu

Sex-specific association between fibroblast growth factor 21 and type 2 diabetes: a nested case-control study in Singapore Chinese men and women

Fibroblast growth factor 21 (FGF-21) is mainly secreted by liver and has been reported to be involved in the pathogenesis of type 2 diabetes. Some prospective studies have shown a positive association between ...

Authors: Yeli Wang, Woon-Puay Koh, Jian-Min Yuan and An Pan

Markers of neuroprotection of combined EPA and DHA provided by fish oil are higher than those of EPA (Nannochloropsis) and DHA (Schizochytrium) from microalgae oils in Wistar rats

To overcome the current overexploitation of fish rich in n-3 long chain polyunsaturated fatty acids (LCPUFA), microalgae have become a promising marine lipid source. The purpose of this study was to assess eicosa...

Authors: Paula A. Lopes, Narcisa M. Bandarra, Susana V. Martins, Joana Martinho, Cristina M. Alfaia, Marta S. Madeira, Carlos Cardoso, Cláudia Afonso, Maria C. Paulo, Rui M. A. Pinto, José L. Guil-Guerrero and José A. M. Prates

Effect of a short-term dietary supplementation with phytosterols, red yeast rice or both on lipid pattern in moderately hypercholesterolemic subjects: a three-arm, double-blind, randomized clinical trial

Phytosterols and red yeast rice are largely studied cholesterol-lowering nutraceuticals, respectively inhibiting the bowel absorption and liver synthesis of cholesterol. Our aim was to test the effect on lipid...

Authors: Arrigo F.G. Cicero, Federica Fogacci, Martina Rosticci, Angelo Parini, Marina Giovannini, Maddalena Veronesi, Sergio D’Addato and Claudio Borghi

Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis

Although the regular consumption of resveratrol has been known to improve glucose homeostasis and reverse insulin resistance in type 2 diabetes mellitus (T2DM), the reported results are inconsistent. Thus, we ...

Authors: Xiangyun Zhu, Chunhua Wu, Shanhu Qiu, Xuelu Yuan and Ling Li

Branched-chain amino acid supplementation restores reduced insulinotropic activity of a low-protein diet through the vagus nerve in rats

Previously, we reported that a low-protein diet significantly reduced insulin secretion in response to feeding within 1 h in rats, suggesting that the insulinotropic effect of dietary protein plays an importan...

Authors: Mami Horiuchi, Tomoya Takeda, Hiroyuki Takanashi, Yori Ozaki-Masuzawa, Yusuke Taguchi, Yuka Toyoshima, Lila Otani, Hisanori Kato, Meri Sone-Yonezawa, Fumihiko Hakuno, Shin-Ichiro Takahashi and Asako Takenaka

Serum metabolites in non-alcoholic fatty-liver disease development or reversion; a targeted metabolomic approach within the PREDIMED trial

Limited prospective studies have examined changes in non-alcoholic fatty-liver disease (NAFLD) related serum-metabolites and none the effects of NAFLD-reversion. We aimed to evaluate whether perturbations in m...

Authors: Christopher Papandreou, Mònica Bullò, Francisco José Tinahones, Miguel Ángel Martínez-González, Dolores Corella, Georgios A. Fragkiadakis, José López-Miranda, Ramon Estruch, Montserrat Fitó and Jordi Salas-Salvadó

Phenylketonuria patients’ and their parents’ knowledge and attitudes to the daily diet - multi-centre study

The aim of the study was to assess both patients’ and their parents’ knowledge of phenylketonuria (PKU) treatment and compliance with PKU diet.

Authors: Ewa Witalis, Bozena Mikoluc, Radoslaw Motkowski, Jolanta Sawicka-Powierza, Agnieszka Chrobot, Bozena Didycz, Agata Lange, Renata Mozrzymas, Andrzej Milanowski, Maria Nowacka, Mariola Piotrowska-Depta, Hanna Romanowska, Ewa Starostecka, Jolanta Wierzba, Magdalena Skorniewska, Barbara Iwona Wojcicka-Bartlomiejczyk…

Recombinant SFRP5 protein significantly alleviated intrahepatic inflammation of nonalcoholic steatohepatitis

Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatit...

Authors: Lili Chen, Xiaolong Zhao, Guangjun Liang, Jiuru Sun, Zhifeng Lin, Renming Hu, Peili Chen, Zhaoyun Zhang, Linuo Zhou and Yiming Li

Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer

There is accumulating evidence that milk shapes the postnatal metabolic environment of the newborn infant. Based on translational research, this perspective article provides a novel mechanistic link between mi...

Authors: Bodo C. Melnik

Effects of a liquid high-fat meal on postprandial lipid metabolism in type 2 diabetic patients with abdominal obesity

Postprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis. This study aimed to evaluate the postprandial lipid metabolism after the ingest...

Authors: Feng Wang, Huixia Lu, Fukang Liu, Huizhen Cai, Zhixiu Song, Fei Guo, Yulan Xie, Guofang Shu and Guiju Sun

Circulating zinc-α2-glycoprotein levels are low in newly diagnosed patients with metabolic syndrome and correlate with adiponectin

Zinc-α2-glycoprotein (ZAG) is a novel adipokine that reduces insulin resistance, protecting against type 2 diabetes. However, past studies have been contradictory. This cross-sectional study aims to investigat...

Authors: Lu Lei, Kejia Li, Ling Li, Xia Fang, Tingting Zhou, Cheng Zhang, Yong Luo, Hua Liu, Xiaoqiang Li, Hongting Zheng, Lin Zhang, Gangyi Yang and Lin Gao

DHA increases adiponectin expression more effectively than EPA at relative low concentrations by regulating PPARγ and its phosphorylation at Ser273 in 3T3-L1 adipocytes

Enhancing circulating adiponectin is considered as a potential approach for the prevention and treatment of non-communicable diseases (NCDs). Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were rep...

Authors: Jia Song, Cheng Li, Yushan Lv, Yi Zhang, William Kwame Amakye and Limei Mao

Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes: a randomized, crossover, controlled feeding trial

Almonds can decrease glycemic index of co-consumed foods and are a rich source for oleic acid and α-tocopherol. The aim of the randomized, crossover, controlled feeding trial was to examine whether as compared...

Authors: Chiao-Ming Chen, Jen-Fang Liu, Sing-Chung Li, Chen-Ling Huang, An-Tsz Hsirh, Shuen-Fu Weng, Mei-Ling Chang, Hung-Ta Li, Emily Mohn and C-Y. Oliver Chen

Season and vitamin D status are independently associated with glucose homeostasis in pregnancy

Vitamin D status and season are intrinsically linked, and both have been proposed to be associated with glucose homeostasis in pregnancy, with conflicting results. We aimed to determine if exposure to winter a...

Authors: Eileen C. O’Brien, Elizabeth J. O’Sullivan, Mark T. Kilbane, Aisling A. Geraghty, Malachi J. McKenna and Fionnuala M. McAuliffe

Lipid accumulation product is a powerful tool to predict non-alcoholic fatty liver disease in Chinese adults

Non-alcoholic fatty liver disease (NAFLD), recognized as the liver manifestation of metabolic syndrome, is highly prevalent in the general population. Recent studies suggest that lipid accumulation product is ...

Authors: Haijiang Dai, Weijun Wang, Ruifang Chen, Zhiheng Chen, Yao Lu and Hong Yuan

eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet

Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development and severity of nonalcoholic fatty liver disease (NAFLD). In response to diverse ce...

Authors: Woo-Gyun Choi, Jaeseok Han, Ji-Hyeon Kim, Mi-Jeong Kim, Jae-Woo Park, Benbo Song, Hee-Jeong Cha, Hye-Seon Choi, Hun-Taeg Chung, In-Kyu Lee, Tae-Sik Park, Maria Hatzoglou, Hueng-Sik Choi, Hyun Ju Yoo, Randal J. Kaufman and Sung Hoon Back

Salivary proline-rich protein may reduce tannin-iron chelation: a systematic narrative review

Tannins are often cited for antinutritional effects, including chelation of non-heme iron. Despite this, studies exploring non-heme iron bioavailability inhibition with long-term consumption have reported mixe...

Authors: Nicole M. Delimont, Sara K. Rosenkranz, Mark D. Haub and Brian L. Lindshield

Positive association between musclin and insulin resistance in obesity: evidence of a human study and an animal experiment

Musclin is a novel skeletal muscle-derived secretory factor considered to be a potent regulator of the glucose metabolism and therefore may contribute to the pathogenesis of obesity and insulin resistance (IR).

Authors: Wen-Jia Chen, Yue Liu, Yu-Bin Sui, Hong-Tao Yang, Jin-Rui Chang, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang and Xin-Hua Yin

Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

Diabetic patients are at an increased risk of developing heart failure when compared to their non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be central in the development o...

Authors: Phiwayinkosi V. Dludla, Elizabeth Joubert, Christo J.F. Muller, Johan Louw and Rabia Johnson

Hepatic, adipocyte, enteric and pancreatic hormones: response to dietary macronutrient composition and relationship with metabolism

We sought to characterize the effects of dietary macronutrient composition on various hormones implicated in the regulation of insulin sensitivity (IS) and energy expenditure (EE).

Authors: Bridget M. Hron, Cara B. Ebbeling, Henry A. Feldman and David S. Ludwig

Piperine enhances carbohydrate/fat metabolism in skeletal muscle during acute exercise in mice

Exercise promotes energy metabolism (e.g., metabolism of glucose and lipids) in skeletal muscles; however, reactive oxygen species are also generated during exercise. Various spices have been reported to have ...

Authors: Jisu Kim, Kang-Pa Lee, Dae-Won Lee and Kiwon Lim

Discrepancies in publications related to HMB-FA and ATP supplementation

This letter addresses a number of discrepancies found in several publications related HMB-FA and ATP supplementation.

Authors: Jeremy A. Gentles and Stuart M. Phillips

Free fatty acids and cardiovascular outcome: a Chinese cohort study on stable coronary artery disease

Studies have revealed that plasma level of free fatty acids (FFAs) is related to cardiovascular disease. However, the role of FFAs in clinical outcomes of stable coronary artery disease (SCAD) has been less ev...

Authors: Hui-Wen Zhang, Xi Zhao, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Jing Sun, Geng Liu, Qian Dong and Jian-Jun Li

Erratum to: Evaluation of Lactobacillus coryniformis CECT5711 strain as a coadjuvant in a vaccination process: a randomised clinical trial in healthy adults

Authors: Noemí Redondo, Esther Nova, Alina Gheorghe, Ligia Esperanza Díaz, Aurora Hernández and Ascensión Marcos

Erratum to: Evaluation of Lactobacillus coryniformis CECT5711 strain as a coadjuvant in a vaccination process: a randomised clinical trial in healthy adults

Authors: Noemí Redondo, Esther Nova, Alina Gheorghe, Ligia Esperanza Díaz, Aurora Hernández and Ascensión Marcos