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  1. Content type: Research

    Although the R230C-ATP-binding cassette A1 (ABCA1) variant has been consistently associated with HDL-C levels, its association with diabetes and other metabolic parameters is unclear. Estrogen and dietary factors...

    Authors: Leonor Jacobo-Albavera, Carlos Posadas-Romero, Gilberto Vargas-Alarcón, Sandra Romero-Hidalgo, Rosalinda Posadas-Sánchez, María del Carmen González-Salazar, Alessandra Carnevale, Samuel Canizales-Quinteros, Aida Medina-Urrutia, Erika Antúnez-Argüelles and Teresa Villarreal-Molina

    Citation: Nutrition & Metabolism 2015 12:45

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  2. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD), characterized as excessive lipid accumulation within hepatocytes, is growing in prevalence. The exploitation of effective drugs for NAFLD has been proven challenging....

    Authors: Wencong Dai, Kunyuan Wang, Xinchun Zheng, Xiaohui Chen, Wenqing Zhang, Yiyue Zhang, Jinlin Hou and Li Liu

    Citation: Nutrition & Metabolism 2015 12:42

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  3. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries. NAFLD encompasses a spectrum of diseases, ranging from hepatic steatosis to non-alcoholic ste...

    Authors: Rafat A. Siddiqui, Zhidong Xu, Kevin A. Harvey, Thomas M. Pavlina, Michael J. Becker and Gary P. Zaloga

    Citation: Nutrition & Metabolism 2015 12:41

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  4. Content type: Research

    Overweight in Guadeloupe is a public health matter affecting children and adults. In the present study we evaluated the metabolic profile, including serum ghrelin, leptin and adiponectin levels, in normal weig...

    Authors: Christine Rambhojan, Elodie Bouaziz-Amar, Laurent Larifla, Jacqueline Deloumeaux, Josiane Clepier, Jean Plumasseau, Jean-Marc Lacorte and Lydia Foucan

    Citation: Nutrition & Metabolism 2015 12:43

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  5. Content type: Research

    Maternal obesity is associated with dysregulation of glucose and lipid metabolism with consequent exposure of the fetus to an abnormal metabolic milieu. It is recognized that maternal obesity predisposes offsp...

    Authors: Sarah J. Glastras, Muh Geot Wong, Hui Chen, Jie Zhang, Amgad Zaky, Carol A. Pollock and Sonia Saad

    Citation: Nutrition & Metabolism 2015 12:40

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  6. Content type: Research

    It is well established that weight is an important determinant of bone health. Whereas obesity is associated with increased mortality and morbidity from diabetes and cardiovascular diseases, high body weight i...

    Authors: A. El Maghraoui, S. Sadni, A. El Maataoui, A. Majjad, A. Rezqi, Z. Ouzzif and A. Mounach

    Citation: Nutrition & Metabolism 2015 12:44

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  7. Content type: Research

    A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals...

    Authors: Steven L. Roseno, Patrick R. Davis, Lance M. Bollinger, Jonathan J. S. Powell, Carol A. Witczak and Jeffrey J. Brault

    Citation: Nutrition & Metabolism 2015 12:39

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  8. Content type: Research

    Fat infiltration of the liver, muscle and pancreas is associated with insulin resistance and risk of diabetes. Weight loss reduces ectopic fat deposition and risk of diabetes, but is difficult to sustain to du...

    Authors: Nicola D. Guess, Anne Dornhorst, Nick Oliver, Jimmy D. Bell, E. Louise Thomas and Gary S. Frost

    Citation: Nutrition & Metabolism 2015 12:36

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  9. Content type: Research

    Energy restriction causes adaptations in energy expenditure (total-,TEE; resting-,REE; activity induced-,AEE).

    Authors: Stefan G. J. A. Camps, Sanne P. M. Verhoef, Nadia Roumans, Freek G. Bouwman, Edwin C. M. Mariman and Klaas R. Westerterp

    Citation: Nutrition & Metabolism 2015 12:37

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  10. Content type: Research

    Site-1 protease (S1P) is the key enzyme required for activation of the sterol regulatory element binding proteins (SREBPs) that govern lipid synthesis. While S1P has been speculated to influence plasma apoB-co...

    Authors: Debapriya Basu, Afroza Huq, Jahangir Iqbal, M. Mahmood Hussain, Xian-Cheng Jiang and Weijun Jin

    Citation: Nutrition & Metabolism 2015 12:35

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  11. Content type: Research

    Severe calorie restriction (CR) is shown to improve or even reverse β-cell dysfunction in patients with obesity and type 2 diabetes mellitus. However, whether mild to moderate CR can reverse β-cell dysfunction...

    Authors: Xiuying Gao, Dien Yan, Yinan Zhao, Hong Tao and Yingsheng Zhou

    Citation: Nutrition & Metabolism 2015 12:34

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  12. Content type: Research

    Obesity-induced hepatic lipid accumulation causes lipotoxicity, mitochondrial dysfunction, oxidative stress, and insulin resistance, and is implicated in non-alcoholic hepatic pathologies such as steatohepatit...

    Authors: Chu-Sook Kim, Yoonhee Kwon, Suck-Young Choe, Sun-Myung Hong, Hoon Yoo, Tsuyoshi Goto, Teruo Kawada, Hye-Seon Choi, Yeonsoo Joe, Hun Taeg Chung and Rina Yu

    Citation: Nutrition & Metabolism 2015 12:33

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  13. Content type: Research

    Recent studies have shown that vitamin-D intake can improve skeletal muscle function and strength in frail vitamin-D insufficient individuals. We investigated whether vitamin-D intake can improve the muscular ...

    Authors: Jakob Agergaard, Jeanette Trøstrup, Jacob Uth, Jonas Vestergard Iversen, Anders Boesen, Jesper L. Andersen, Peter Schjerling and Henning Langberg

    Citation: Nutrition & Metabolism 2015 12:32

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  14. Content type: Research

    Obesity is significant problem involving eating behavior and peripheral metabolic conditions. The effect of carbohydrate and fat restriction on appetite regulation, fibroblast growth factor 21 (FGF21) and lept...

    Authors: Lorena del Rocío Ibarra-Reynoso, Liudmila Pisarchyk, Elva Leticia Pérez-Luque, Ma. Eugenia Garay-Sevilla and Juan Manuel Malacara

    Citation: Nutrition & Metabolism 2015 12:31

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  15. Content type: Research

    Individuals with insulin resistance and resulting impaired glucose tolerance along with type 2 diabetes showed an increased prevalence of atherosclerosis. Our aim in this study was to address whether diet-indu...

    Authors: Bo Ning, Xiaoyan Wang, Ying Yu, Ahmed Bilal Waqar, Qi Yu, Tomonari Koike, Masashi Shiomi, Enqi Liu, Yifei Wang and Jianglin Fan

    Citation: Nutrition & Metabolism 2015 12:30

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  16. Content type: Research

    Both aging and obesity are related to dysregulated immune function, which may be responsible for increased risk of infection and also chronic non-infectious diseases. Dietary lipids have been shown to impact i...

    Authors: Mitra Rozati, Junaidah Barnett, Dayong Wu, Garry Handelman, Edward Saltzman, Thomas Wilson, Lijun Li, Junpeng Wang, Ascensión Marcos, José M. Ordovás, Yu-Chi Lee, Mohsen Meydani and Simin Nikbin Meydani

    Citation: Nutrition & Metabolism 2015 12:28

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  17. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD) is rapidly turning into the most common liver disorder worldwide. One of the strategies that has been shown to effectively improve NAFLD is regular exercise, which see...

    Authors: Sheril Alex, Andreas Boss, Arend Heerschap and Sander Kersten

    Citation: Nutrition & Metabolism 2015 12:29

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  18. Content type: Research

    Diacylglyceride acyltransferase 1 (DGAT1) is the enzyme that adds the final fatty acid on to a diacylglyceride during triglyceride (TG) synthesis. DGAT1 plays a key role in the repackaging of dietary TG into c...

    Authors: Rodney A. Velliquette, Kerry Grann, Stephen R. Missler, Jennifer Patterson, Chun Hu, Kevin W. Gellenbeck, Jeffrey D. Scholten and R. Keith Randolph

    Citation: Nutrition & Metabolism 2015 12:27

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  19. Content type: Review

    Zinc is a mineral that plays a vital role in many biological processes and plays an important role in insulin action and carbohydrate metabolism. It may also have a protective role in the prevention of atherog...

    Authors: Priyanga Ranasinghe, WS Wathurapatha, MH Ishara, R. Jayawardana, P. Galappatthy, P. Katulanda and GR Constantine

    Citation: Nutrition & Metabolism 2015 12:26

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  20. Content type: Perspective

    Intakes of high sugar-sweetened beverages (SSBs) in adults can escalate risk of metabolic syndrome (MetS); however, data of longitudinal studies in children and adolescents are lacking. In this study we assess...

    Authors: Parvin Mirmiran, Emad Yuzbashian, Golaleh Asghari, Somayeh Hosseinpour-Niazi and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2015 12:25

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  21. Content type: Research

    Body mass index (BMI) and serum 25-hydroxy vitamin D3 (25OHD) concentrations are inversely related. As BMI contains only limited information regarding body fat distribution, we aimed to analyze the cross-secti...

    Authors: A. Hannemann, B. Heinsbaek Thuesen, N. Friedrich, H. Völzke, A. Steveling, T. Ittermann, K. Hegenscheid, M. Nauck, A. Linneberg and H. Wallaschofski

    Citation: Nutrition & Metabolism 2015 12:24

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  22. Content type: Research

    Ammonia detoxification is essential for physiological well-being, and the urea cycle in liver plays a predominant role in ammonia disposal. Nobiletin (NOB), a natural dietary flavonoid, is known to exhibit var...

    Authors: Kazunari Nohara, Youngmin Shin, Noheon Park, Kwon Jeong, Baokun He, Nobuya Koike, Seung-Hee Yoo and Zheng Chen

    Citation: Nutrition & Metabolism 2015 12:23

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  23. Content type: Research

    Cytokines secreted by adipose tissue macrophages (ATMs) significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. However, little relevant information is avail...

    Authors: Yaqin Zhang, Li Shi, Hongliang Mei, Jiexin Zhang, Yunxia Zhu, Xiao Han and Dalong Zhu

    Citation: Nutrition & Metabolism 2015 12:21

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  24. Content type: Research

    A large body of evidence suggests that atherosclerosis is an inflammatory disease, in which cytokines and growth factors play a major role in disease progression. The methanolic extracts of Sphaeranthus indicus a...

    Authors: Rai Ajit K. Srivastava, Sapna Mistry and Somesh Sharma

    Citation: Nutrition & Metabolism 2015 12:20

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  25. Content type: Research

    Abdominal obesity is a major risk factor for insulin resistance, type 2 diabetes and cardiovascular diseases. Dietary fat induces insulin resistance in humans and rodents. The current study investigates whethe...

    Authors: Hilda E Ghadieh, Zachary N Smiley, Melissa W Kopfman, Mona G Najjar, Michael J Hake and Sonia M Najjar

    Citation: Nutrition & Metabolism 2015 12:19

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  26. Content type: Research

    South Asians were reported to have a higher liver fat content as compared to BMI-matched Caucasians. This study compared the increase in liver fat content in response to overfeeding with a high fat diet in Sou...

    Authors: Siti N. Wulan, Vera B. Schrauwen-Hinderling, Klaas R. Westerterp and Guy Plasqui

    Citation: Nutrition & Metabolism 2015 12:18

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  27. Content type: Research

    Diet-induced hepatic steatosis is highly associated with nonalcoholic fatty liver disease, which is related to the development of metabolic syndrome. While advanced stage nonalcoholic hepatic steatosis and ste...

    Authors: Yasuhito Shimada, Shisei Kuninaga, Michiko Ariyoshi, Beibei Zhang, Yasuhiko Shiina, Yoshinori Takahashi, Noriko Umemoto, Yuhei Nishimura, Hiroyuki Enari and Toshio Tanaka

    Citation: Nutrition & Metabolism 2015 12:17

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  28. Content type: Review

    The ability of inorganic nitrate and nitrite to convert to nitric oxide (NO), and some of its properties e.g. regulation of glucose metabolism, vascular homeostasis, and insulin signaling pathway, have recentl...

    Authors: Zahra Bahadoran, Asghar Ghasemi, Parvin Mirmiran, Fereidoun Azizi and Farzad Hadaegh

    Citation: Nutrition & Metabolism 2015 12:16

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  29. Content type: Brief communication

    Cigarette smoking is associated with an increased risk of type 2 diabetes mellitus (T2DM). Smokers exhibit low circulating levels of total adiponectin (ADPN) and high-molecular-weight (HMW) ADPN multimers. Blo...

    Authors: Mingzhen Li, Chunjun Li, Yu Liu, Yan Chen, Xiangdong Wu, Demin Yu, Victoria P Werth, Kevin Jon Williams and Ming-Lin Liu

    Citation: Nutrition & Metabolism 2015 12:15

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  30. Content type: Research

    There is great interest in the relationship between polyunsaturated fatty acids and health. Yet, the combinatory effect of factors such as sex, ethnicity, genetic polymorphisms and hormonal contraceptives (HC)...

    Authors: Salma A Abdelmagid, Shannon E Clarke, Kaitlin Roke, Daiva E Nielsen, Alaa Badawi, Ahmed El-Sohemy, David M Mutch and David WL Ma

    Citation: Nutrition & Metabolism 2015 12:14

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  31. Content type: Research

    Riboflavin (RF) is essential for normal cellular metabolic activities. Human cells obtain RF from their surroundings via a carrier-mediated process that involves RF transporters -1, -2 & -3 (hRFVT -1, -2 & -3;...

    Authors: Veedamali S Subramanian, Rubina Kapadia, Abhisek Ghosal and Hamid M Said

    Citation: Nutrition & Metabolism 2015 12:13

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  32. Content type: Methodology

    Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic f...

    Authors: Joshua J Meidenbauer, Purna Mukherjee and Thomas N Seyfried

    Citation: Nutrition & Metabolism 2015 12:12

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  33. Content type: Research

    Pharmacological stimulation of peroxisome proliferator-activated receptor-gamma (PPAR-γ) has been recognized as a molecular switch in alleviating myocardial injury through modulating oxidative, inflammatory an...

    Authors: Neha Rani, Saurabh Bharti, Jagriti Bhatia, Ameesha Tomar, T C Nag, Ruma Ray and Dharamvir Singh Arya

    Citation: Nutrition & Metabolism 2015 12:11

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  34. Content type: Research

    The hallmark of Type 2 diabetes (T2D) is hyperglycemia, although there are multiple other metabolic abnormalities that occur with T2D, including insulin resistance and dyslipidemia. To advance T2D prevention a...

    Authors: Amit Kumar, Joseph Shiloach, Michael J Betenbaugh and Emily J Gallagher

    Citation: Nutrition & Metabolism 2015 12:8

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  35. Content type: Research

    Dementia induced by β-amyloid accumulation impairs peripheral glucose homeostasis, but red pepper extract improves glucose homeostasis. We therefore evaluated whether long-term oral consumption of different re...

    Authors: Hye Jeong Yang, Dae Young Kwon, Min Jung Kim, Suna Kang, Na Rang Moon, James W Daily and Sunmin Park

    Citation: Nutrition & Metabolism 2015 12:9

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  36. Content type: Research

    Diet has a significant relationship with the risk of coronary heart disease (CHD). Traditionally the effect of diet on CHD was measured with the biomarker for low-density lipoprotein (LDL) cholesterol. However...

    Authors: Marc J Mathews, Leon Liebenberg and Edward H Mathews

    Citation: Nutrition & Metabolism 2015 12:6

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  37. Content type: Research

    n-3 long chain polyunsaturated fatty acid (n-3 LC PUFA) increases β-oxidation and limits lipid accumulation in adipocytes. The current study was conducted to determine whether their precursor alpha-linolenic a...

    Authors: Xihong Zhou, Weiche Wu, Jingqing Chen, Xinxia Wang and Yizhen Wang

    Citation: Nutrition & Metabolism 2015 12:10

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  38. Content type: Brief communication

    Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have ...

    Authors: Karani Santhanakrishnan Vimaleswaran, Anne M Minihane, Yue Li, Rosalyn Gill, Julie A Lovegrove, Christine M Williams and Kim G Jackson

    Citation: Nutrition & Metabolism 2015 12:7

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  39. Content type: Research

    Accumulative evidence in the literature suggests alcohol consumption is a protective factor of the metabolic syndrome (MS). However, few studies investigated the relationship between alcohol consumption and co...

    Authors: Jing Xiao, Jian-Ping Huang, Guang-Fei Xu, De-Xi Chen, Gui-Yun Wu, Min Zhang, Yi Shen and Hui Cai

    Citation: Nutrition & Metabolism 2015 12:5

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  40. Content type: Review

    This comprehensive review critically evaluates whether supposed health benefits propounded upon human consumption of conjugated linoleic acids (CLAs) are clinically proven or not. With a general introduction o...

    Authors: Sailas Benjamin, Priji Prakasan, Sajith Sreedharan, Andre-Denis G Wright and Friedrich Spener

    Citation: Nutrition & Metabolism 2015 12:4

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  41. Content type: Research

    Considering the suggested link between vitamin D insufficiency and several chronic diseases, attention should be given to approaches for improving vitamin D status. Elderly subjects are regarded as a high-risk...

    Authors: Alexandra Jungert and Monika Neuhäuser-Berthold

    Citation: Nutrition & Metabolism 2015 12:2

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  42. Content type: Research

    Adverse metabolic changes associated with loss of ovarian function increase the risk of developing metabolic syndrome and non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. Naringenin improves ...

    Authors: Jia-Yu Ke, Kara L Kliewer, Essam M Hamad, Rachel M Cole, Kimerly A Powell, Rebecca R Andridge, Shana R Straka, Lisa D Yee and Martha A Belury

    Citation: Nutrition & Metabolism 2015 12:1

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  43. Content type: Research

    The aim of the present study was to examine the effects of onion as functional ingredient on the oxidative status, lipoprotein levels (total cholesterol-TC, HDL-C, LDL-C), triacylglycerides (TAG) and vascular ...

    Authors: Diana González-Peña, Javier Angulo, Susana Vallejo, Clara Colina-Coca, Begoña de Ancos, Carlos F Sánchez-Ferrer, Concepción Peiró and Concepción Sánchez-Moreno

    Citation: Nutrition & Metabolism 2014 11:57

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  44. Content type: Research

    African-Americans have higher HDL, less visceral adipose tissue (VAT) and lower triglyceride (TG) and apoCIII concentrations than whites, despite being more insulin-resistant. We studied in African-American an...

    Authors: Liyun Wang, Frank M Sacks, Jeremy D Furtado, Madia Ricks, Amber B Courville and Anne E Sumner

    Citation: Nutrition & Metabolism 2014 11:56

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  45. Content type: Research

    Hyperhomocysteinemia (HHcy) is an independent risk factor for liver diseases, such as fatty liver and hepatic fibrosis. However, the mechanisms underlying this pro-oxidative effect of homocysteine (Hcy) in hep...

    Authors: Xiaoqin Luo, Lei Xiao, Haixia Yang, Ruijuan Zhang, Manli Jiang, Jiahua Ni, Ting Lei and Nanping Wang

    Citation: Nutrition & Metabolism 2014 11:55

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  46. Content type: Research

    Members of the ALDH1 protein family, known as retinal dehydrogenases (RALDH), produce retinoic acid (RA), a metabolite of vitamin A, and may also oxidize other lipid aldehydes. Of three related ALDH1 genes, AL...

    Authors: Kyoko Ito, Reza Zolfaghari, Lei Hao and A Catharine Ross

    Citation: Nutrition & Metabolism 2014 11:54

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