Beijers R, van de Bool C, van den Borst B, Franssen FME, Wouters EFM, Schols A. Normal weight but low muscle mass and abdominally obese: implications for the cardiometabolic risk profile in chronic obstructive pulmonary disease. J Am Med Dir Assoc. 2017;18(6):533–8.
Article
PubMed
Google Scholar
Boulet MM, Chevrier G, Grenier-Larouche T, Pelletier M, Nadeau M, Scarpa J, et al. Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk. Am J Physiol Endocrinol Metab. 2015;309(8):E736–46.
Article
CAS
PubMed
Google Scholar
van den Borst B, Gosker HR, Koster A, Yu B, Kritchevsky SB, Liu Y, et al. The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease. Am J Clin Nutr. 2012;96(3):516–26.
Article
PubMed
PubMed Central
Google Scholar
Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, et al. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011;17(4):448–53.
Article
PubMed
PubMed Central
Google Scholar
Ubhi BK, Riley JH, Shaw PA, Lomas DA, Tal-Singer R, MacNee W, et al. Metabolic profiling detects biomarkers of protein degradation in COPD patients. Eur Respir J. 2012;40(2):345–55.
Article
CAS
PubMed
Google Scholar
Engelen MPKJ, Wouters EFM, Deutz NE, Menheere PP, Schols AM. Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease. Am J Clin Nutr. 2000;72(6):1480–7.
Article
CAS
PubMed
Google Scholar
Newgard CB. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab. 2012;15(5):606–14.
Article
CAS
PubMed
PubMed Central
Google Scholar
Deutz NEP, Singer P, Wierzchowska-McNew RA, Viana MV, Ben-David IA, Pantet O, et al. Comprehensive metabolic amino acid flux analysis in critically ill patients. Clin Nutr. 2021;40(5):2876–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Maatman RC, Spruit MA, Van Melick PP, Peeters JP, Rutten EP, Vanfleteren LE, et al. Effects of obesity on weight-bearing versus weight-supported exercise testing in patients with COPD. Respirology. 2016;21(3):483–8.
Article
PubMed
Google Scholar
van de Bool C, Rutten EP, Franssen FM, Wouters EF, Schols AM. Antagonistic implications of sarcopenia and abdominal obesity on physical performance in COPD. Eur Respir J. 2015;46(2):336–45.
Article
PubMed
Google Scholar
Joppa P, Tkacova R, Franssen FM, Hanson C, Rennard SI, Silverman EK, et al. Sarcopenic obesity, functional outcomes, and systemic inflammation in patients with chronic obstructive pulmonary disease. J Am Med Dir Assoc. 2016;17(8):712–8.
Article
PubMed
Google Scholar
Hou Q, Guan Y, Yu W, Liu X, Wu L, Xiao M, et al. Associations between obesity and cognitive impairment in the Chinese elderly: an observational study. Clin Interv Aging. 2019;14:367.
Article
PubMed
PubMed Central
Google Scholar
Cleutjens FA, Janssen DJ, Ponds RW, Dijkstra JB, Wouters EF. COgnitive-pulmonary disease. Biomed Res Int. 2014;2014:697825.
Article
PubMed
PubMed Central
Google Scholar
Chan SMH, Selemidis S, Bozinovski S, Vlahos R. Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies. Pharmacol Ther. 2019;198:160–88.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vogelmeier CF, Criner GJ, Martinez FJ, Anzueto A, Barnes PJ, Bourbeau J, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med. 2017;195(5):557–82.
Article
CAS
PubMed
Google Scholar
da Rosa SE, Costa AC, Fortes MSR, Marson RA, Neves EB, Rodrigues LC, et al. Cut-off points of visceral adipose tissue associated with metabolic syndrome in military men. Healthcare. 2021;9(7):886.
Article
PubMed
PubMed Central
Google Scholar
Staynor J, Smith MK, Donnelly CJ, Sallam AE, Ackland TR. DXA reference values and anthropometric screening for visceral obesity in Western Australian adults. Sci Rep. 2020;10(1):1–11.
Article
Google Scholar
Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general US population. Am J Respir Crit Care Med. 1999;159(1):179–87.
Article
CAS
PubMed
Google Scholar
Quan HD, Li B, Couris CM, Fushimi K, Graham P, Hider P, et al. Updating and validating the charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173(6):676–82.
Article
PubMed
Google Scholar
Deutz NEP, Thaden JJ, Ten Have GAM, Walker DK, Engelen M. Metabolic phenotyping using kinetic measurements in young and older healthy adults. Metab Clin Exp. 2018;78:167–78.
Article
CAS
PubMed
Google Scholar
Engelen MPKJ, Jonker R, Thaden JJ, Ten Have GAM, Jeon MS, Dasarathy S, et al. Comprehensive metabolic flux analysis to explain skeletal muscle weakness in COPD. Clin Nutr. 2020;39(10):3056–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Abumrad NN, Rabin D, Diamond MP, Lacy WW. Use of a heated superficial hand vein as an alternative site for the measurement of amino-acid-concentrations and for the study of glucose and alanine kinetics in man. Metab Clin Exp. 1981;30(9):936–40.
Article
CAS
PubMed
Google Scholar
Cruthirds CL, van der Meij BS, Wierzchowska-McNew A, Deutz NEP, Engelen MPKJ. Presence or absence of skeletal muscle dysfunction in chronic obstructive pulmonary disease is associated with distinct phenotypes. Arch Bronconeumol (Engl Ed). 2021;57(4):264–72.
Article
PubMed
Google Scholar
Abd El Aziz AA, Elwahsh RA, Abdelaal GA, Abdullah MS, Saad RA. Diaphragmatic assessment in COPD patients by different modalities. Egypt J Chest Dis Tuberc. 2017;66(2):247–50.
Article
Google Scholar
Bowie CR, Harvey PD. Administration and interpretation of the Trail Making Test. Nat Protoc. 2006;1(5):2277–81.
Article
CAS
PubMed
Google Scholar
Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361–70.
Article
CAS
PubMed
Google Scholar
Glickman ME, Rao SR, Schultz MR. False discovery rate control is a recommended alternative to Bonferroni-type adjustments in health studies. J Clin Epidemiol. 2014;67(8):850–7.
Article
PubMed
Google Scholar
Benjamini Y, Krieger AM, Yekutieli D. Adaptive linear step-up procedures that control the false discovery rate. Biometrika. 2006;93(3):491–507.
Article
Google Scholar
Johnson M, Woodcock A, Rehahn M, Geddes D. Are" pink puffers" more breathless than" blue bloaters"? Br Med J (Clin Res Ed). 1983;286(6360):179–82.
Article
CAS
PubMed
Google Scholar
Engelen MPKJ, Schols AMWJ, Lamers R, Wouters EFM. Different patterns of chronic tissue wasting among patients with chronic obstructive pulmonary disease. Clin Nutr. 1999;18(5):275–80.
Article
CAS
PubMed
Google Scholar
Engelen MPKJ, Schols AMWJ, Does JD, Wouters EFM. Skeletal muscle weakness is associated with wasting of extremity fat-free mass but not with airflow obstruction in patients with chronic obstructive pulmonary disease. Am J Clin Nutr. 2000;71(3):733–8.
Article
CAS
PubMed
Google Scholar
Leem AY, Kim YS, Chung KS, Park MS, Kang Y, Park Y-M, et al. Sarcopenia is associated with cardiovascular risk in men with COPD, independent of adiposity. Respir Res. 2022;23(1):1–12.
Article
Google Scholar
Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metab Clin Exp. 2017;69:120–9.
Article
CAS
PubMed
Google Scholar
Donini LM, Busetto L, Bauer JM, Bischoff S, Boirie Y, Cederholm T, et al. Critical appraisal of definitions and diagnostic criteria for sarcopenic obesity based on a systematic review. Clin Nutr. 2020;39(8):2368–88.
Article
PubMed
Google Scholar
Wedell-Neergaard AS, Lang Lehrskov L, Christensen RH, Legaard GE, Dorph E, Larsen MK, et al. Exercise-induced changes in visceral adipose tissue mass are regulated by IL-6 signaling: a randomized controlled trial. Cell Metab. 2019;29(4):844–55.
Article
CAS
PubMed
Google Scholar
Vassiliou AG, Vitsas V, Kardara M, Keskinidou C, Michalopoulou P, Rovina N, et al. Study of inflammatory biomarkers in COPD and asthma exacerbations. Adv Respir Med. 2020;88(6):558–66.
Article
PubMed
Google Scholar
Fortuño A, Rodríguez A, Gómez-Ambrosi J, Muñiz P, Salvador J, Díez J, et al. Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Endocrinology. 2002;143(9):3555–60.
Article
PubMed
Google Scholar
Engelen MPKJ, De Castro CL, Rutten EP, Wouters EFM, Schols AMWJ, Deutz NEP. Enhanced anabolic response to milk protein sip feeding in elderly subjects with COPD is associated with a reduced splanchnic extraction of multiple amino acids. Clin Nutr. 2012;31(5):616–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ruiz-Canela M, Toledo E, Clish CB, Hruby A, Liang L, Salas-Salvado J, et al. Plasma branched-chain amino acids and incident cardiovascular disease in the PREDIMED trial. Clin Chem. 2016;62(4):582–92.
Article
CAS
PubMed
PubMed Central
Google Scholar
Asoudeh F, Salari-Moghaddam A, Keshteli AH, Esmaillzadeh A, Adibi P. Dietary intake of branched-chain amino acids in relation to general and abdominal obesity. Eat Weight Disord Stud Anorex Bulimia Obes. 2022;27(4):1303–11.
Article
Google Scholar
Engelen MPKJ, Orozco-Levi M, Deutz NEP, Barreiro E, Hernandez N, Wouters EFM, et al. Glutathione and glutamate levels in the diaphragm of patients with chronic obstructive pulmonary disease. Eur Respir J. 2004;23(4):545–51.
Article
CAS
PubMed
Google Scholar
Engelen MPKJ, Com G, Deutz NEP. Increased whole body hydroxyproline production as assessed by a new stable isotope technique is associated with hip and spine bone mineral loss in cystic fibrosis. Clin Nutr. 2014;33(6):1117–21.
Article
CAS
PubMed
Google Scholar
Marcinkiewicz J, Kontny E. Taurine and inflammatory diseases. Amino Acids. 2014;46(1):7–20.
Article
CAS
PubMed
Google Scholar
Machado FV, Spruit MA, Groenen MT, Houben-Wilke S, van Melick PP, Hernandes NA, et al. Frequency and functional translation of low muscle mass in overweight and obese patients with COPD. Resp Res. 2021;22(1):1–8.
Google Scholar
Solano JP, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manag. 2006;31(1):58–69.
Article
Google Scholar
Catalfo G, Crea L, Castro TL, San Lio FM, Minutolo G, Siscaro G, et al. Depression, body mass index, and chronic obstructive pulmonary disease: a holistic approach. Int J Chronic Obstr Pulm Dis. 2016;11:239.
CAS
Google Scholar
Janssen DJ, Spruit MA, Leue C, Gijsen C, Hameleers H, Schols JM, et al. Symptoms of anxiety and depression in COPD patients entering pulmonary rehabilitation. Chronic Respir Dis. 2010;7(3):147–57.
Article
Google Scholar
Putcha N, Drummond MB, Wise RA, Hansel NN. Comorbidities and chronic obstructive pulmonary disease: prevalence, influence on outcomes, and management. Semin Respir Crit Care Med. 2015;36:575–91.
Article
PubMed
PubMed Central
Google Scholar
Zhang C, Rexrode KM, Van Dam RM, Li TY, Hu FB. Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality. Circulation. 2008;117(13):1658–67.
Article
PubMed
Google Scholar
Rondanelli M, Nichetti M, Peroni G, Naso M, Faliva MA, Iannello G, et al. Effect of a food for special medical purposes for muscle recovery, consisting of arginine, glutamine and beta-hydroxy-beta-methylbutyrate on body composition and skin health in overweight and obese class I sedentary postmenopausal women. Nutrients. 2021;13(3):975.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fonseca VA. Effects of beta-blockers on glucose and lipid metabolism. Curr Med Res Opin. 2010;26(3):615–29.
Article
CAS
PubMed
Google Scholar
Lainscak M, Keber I, Anker SD. Body composition changes in patients with systolic heart failure treated with beta blockers: a pilot study. Int J Cardiol. 2006;106(3):319–22.
Article
PubMed
Google Scholar
Caldwell R, Lamont LS. Beta-blockers and their effects on protein metabolism and resting energy expenditure. J Cardiopulm Rehabil Prev. 1995;15(3):183–5.
Article
Google Scholar
Volkert D, Schrader E. Dietary assessment methods for older persons: what is the best approach? Curr Opin Clin Nutr Metab Care. 2013;16(5):534–40.
Article
PubMed
Google Scholar