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  1. Content type: Research

    It is difficult to study the mechanisms of the metabolic syndrome in humans due to the heterogeneous genetic background and lifestyle. The present study investigated changes in the gene and protein profiles in...

    Authors: Jie Chang, Shinji Oikawa, Gaku Ichihara, Yui Nanpei, Yasuhiro Hotta, Yoshiji Yamada, Saeko Tada-Oikawa, Hitoshi Iwahashi, Emiko Kitagawa, Ichiro Takeuchi, Masao Yuda and Sahoko Ichihara

    Citation: Nutrition & Metabolism 2012 9:87

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  2. Content type: Research

    DOR/TP53INP2 acts both at the chromosomal level as a nuclear co-factor e.g. for the thyroid hormone receptor and at the extrachromosomal level as an organizing factor of the autophagosome. In a previous study,...

    Authors: Carolin Fromm-Dornieden, Oleksandr Lytovchenko, Silvia von der Heyde, Nina Behnke, Sebastian Hogl, Janina Berghoff, Frederik Köpper, Lennart Opitz, Ulla Renne, Andreas Hoeflich, Tim Beissbarth, Bertram Brenig and Bernhard G Baumgartner

    Citation: Nutrition & Metabolism 2012 9:86

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  3. Content type: Research

    The prevalence of obesity is increasing exponentially world over. Leptin resistance/hyperleptinemia is attributed to its cause in majority of the obese humans where mutation in genetic component or ob gene has...

    Authors: Satish Kumar Taneja, Reshu Mandal and Aman Chechi

    Citation: Nutrition & Metabolism 2012 9:85

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  4. Content type: Research

    Oxidative stress plays an important role in diabetes-induced vascular inflammation and pathogenesis. Nuclear factor E2-related factor-2 (Nrf2) is a transcription factor orchestrating antioxidant and cyto-prote...

    Authors: Xiao Miao, Yang Bai, Weixia Sun, Wenpeng Cui, Ying Xin, Yuehui Wang, Yi Tan, Lining Miao, Yaowen Fu, Guanfang Su and Lu Cai

    Citation: Nutrition & Metabolism 2012 9:84

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  5. Content type: Review

    Caloric restriction is one of the most efficient ways to promote weight loss and is known to activate protective metabolic pathways. Frequently reported with weight loss is the undesirable consequence of fat f...

    Authors: Cassandra M McIver, Thomas P Wycherley and Peter M Clifton

    Citation: Nutrition & Metabolism 2012 9:83

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  6. Content type: Research

    The Daniel Fast is a vegan diet that prohibits the consumption of animal products, refined foods, white flour, preservatives, additives, sweeteners, flavorings, caffeine, and alcohol. Following this dietary pl...

    Authors: John F Trepanowski, Mohammad M Kabir, Rick J Alleman Jr and Richard J Bloomer

    Citation: Nutrition & Metabolism 2012 9:82

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  7. Content type: Review

    Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism. In contrast to protein restriction during fetal lif...

    Authors: Júlio Cezar de Oliveira, Sabrina Grassiolli, Clarice Gravena and Paulo Cezar Freitas de Mathias

    Citation: Nutrition & Metabolism 2012 9:80

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  8. Content type: Research

    Dietary glycemic index or load is thought to play an important role in glucose metabolism. However, few studies have investigated the relation between glycemic index (GI) or load (GL) and glycemia in Asian pop...

    Authors: Maki Goto, Akemi Morita, Atsushi Goto, Satoshi Sasaki, Naomi Aiba, Takuro Shimbo, Yasuo Terauchi, Motohiko Miyachi, Mitsuhiko Noda and Shaw Watanabe

    Citation: Nutrition & Metabolism 2012 9:79

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  9. Content type: Research

    In humans, skipping meals, especially breakfast, has been associated with obesity and other related syndromes. Recent studies in rodents suggest that fasting and feeding times are potential factors that affect...

    Authors: Chika Yoshida, Nahoko Shikata, Shinobu Seki, Naoto Koyama and Yasushi Noguchi

    Citation: Nutrition & Metabolism 2012 9:78

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  10. Content type: Research

    Sirtuins are important regulators of glucose and fat metabolism, and sirtuin activation has been proposed as a therapeutic target for insulin resistance and diabetes. We have shown leucine to increase mitochon...

    Authors: Antje Bruckbauer, Michael B Zemel, Teresa Thorpe, Murthy R Akula, Alan C Stuckey, Dustin Osborne, Emily B Martin, Stephen Kennel and Jonathan S Wall

    Citation: Nutrition & Metabolism 2012 9:77

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  11. Content type: Research

    The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.

    Authors: Mireia Olivan, Jochen Springer, Sílvia Busquets, Anika Tschirner, Maite Figueras, Miriam Toledo, Cibely Fontes-Oliveira, Maria Inés Genovese, Paula Ventura da Silva, Angelica Sette, Francisco J López-Soriano, Stefan Anker and Josep M Argilés

    Citation: Nutrition & Metabolism 2012 9:76

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  12. Content type: Review

    Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth signaling. The nutrient-sensitive kinase mTORC1 is upre...

    Authors: Bodo C Melnik, Swen Malte John, Pedro Carrera-Bastos and Loren Cordain

    Citation: Nutrition & Metabolism 2012 9:74

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  13. Content type: Research

    Visceral fat accumulation is one of the most important predictors of mortality in obese populations. Administration of green tea extract (GTE) can reduce body fat and reduce the risk of obesity-related disease...

    Authors: Takahiro Hasumura, Yasuhito Shimada, Junya Kuroyanagi, Yuhei Nishimura, Shinichi Meguro, Yoshinori Takema and Toshio Tanaka

    Citation: Nutrition & Metabolism 2012 9:73

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  14. Content type: Research

    There is growing evidence that dietary antioxidants could have favorable effects on the attenuation and prevention of metabolic disorders. In the current study we investigated the association of dietary total ...

    Authors: Zahra Bahadoran, Mahdieh Golzarand, Parvin Mirmiran, Niloofar Shiva and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2012 9:70

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  15. Content type: Review

    Sphingolipids are ubiquitous and critical components of biological membranes. Their biosynthesis starts with soluble precursors in the endoplasmic reticulum and culminates in the Golgi complex and plasma membr...

    Authors: M Mahmood Hussain, Weijun Jin and Xian-Cheng Jiang

    Citation: Nutrition & Metabolism 2012 9:71

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  16. Content type: Research

    High fat feeding in rodents generally leads to obesity and insulin resistance whereas in humans this is only seen if dietary carbohydrate is also high, the result of the anabolic effect of poor regulation of g...

    Authors: Saihan Borghjid and Richard David Feinman

    Citation: Nutrition & Metabolism 2012 9:69

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  17. Content type: Research

    Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effec...

    Authors: Chad L Cox, Kimber L Stanhope, Jean Marc Schwarz, James L Graham, Bonnie Hatcher, Steven C Griffen, Andrew A Bremer, Lars Berglund, John P McGahan, Nancy L Keim and Peter J Havel

    Citation: Nutrition & Metabolism 2012 9:68

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  18. Content type: Research

    Leucine (Leu) regulates muscle protein synthesis (MPS) producing dose-dependent plasma Leu and MPS responses from free amino acid solutions. This study examined the role of Leu content from dietary proteins in...

    Authors: Layne E Norton, Gabriel J Wilson, Donald K Layman, Christopher J Moulton and Peter J Garlick

    Citation: Nutrition & Metabolism 2012 9:67

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  19. Content type: Research

    Genome-wide association studies (GWAS) have recently identified several new genetic variants associated with obesity. The majority of the variants are within introns or between genes, suggesting they affect ge...

    Authors: Piriya Yoganathan, Subashini Karunakaran, Maggie M Ho and Susanne M Clee

    Citation: Nutrition & Metabolism 2012 9:65

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  20. Content type: Research

    Obesity associates with low-grade inflammation and adipose tissue remodeling. Using sensitive high-throughput protein arrays we here investigated adipose tissue cytokine and angiogenesis-related protein profil...

    Authors: Eveliina Kurki, Jin Shi, Essi Martonen, Piet Finckenberg and Eero Mervaala

    Citation: Nutrition & Metabolism 2012 9:64

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  21. Content type: Brief communication

    Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt ...

    Authors: Waleska Cláudia Dornas, Wanderson Geraldo de Lima, Rinaldo Cardoso dos Santos, Melina Oliveira de Souza, Maísa Silva, Mirla Fiuza Diniz and Marcelo Eustáquio Silva

    Citation: Nutrition & Metabolism 2012 9:63

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  22. Content type: Research

    Small-for-gestational age (SGA) at birth increases risk of development of adult obesity and insulin resistance. A model of SGA rat offspring has been shown to exhibit increased adipose tissue expression of a k...

    Authors: Jennifer K Yee, Wai-Nang Paul Lee, Michael G Ross, Robert H Lane, Guang Han, Juan Vega and Mina Desai

    Citation: Nutrition & Metabolism 2012 9:62

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  23. Content type: Research

    The prevalence of obesity among Mexican women is high and it could be related to micronutrient status. We evaluated in a cross-sectional study the associations of zinc and vitamins A, C and E concentrations wi...

    Authors: Olga Patricia García, Dolores Ronquillo, María del Carmen Caamaño, Mariela Camacho, Kurt Zane Long and Jorge L Rosado

    Citation: Nutrition & Metabolism 2012 9:59

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  24. Content type: Research

    Increased amino acid availability stimulates muscle protein synthesis, however, aged muscle appears less responsive to the anabolic effects of amino acids when compared to the young. We aimed to compare change...

    Authors: Yifan Yang, Tyler A Churchward-Venne, Nicholas A Burd, Leigh Breen, Mark A Tarnopolsky and Stuart M Phillips

    Citation: Nutrition & Metabolism 2012 9:57

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  25. Content type: Research

    Recent evidence suggests that the effects of certain food additives may be synergistic or additive. Aspartame (ASP) and Monosodium Glutamate (MSG) are ubiquitous food additives with a common moiety: both conta...

    Authors: Kate S Collison, Nadine J Makhoul, Marya Z Zaidi, Rana Al-Rabiah, Angela Inglis, Bernard L Andres, Rosario Ubungen, Mohammed Shoukri and Futwan A Al-Mohanna

    Citation: Nutrition & Metabolism 2012 9:58

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  26. Content type: Research

    Although the measurement site at L4–L5 for visceral adipose tissue (VAT) has been commonly accepted, some researchers suggest that additional upper sites (i.e., L1–L2 and L2–L3) are useful for estimating VAT v...

    Authors: Rina So, Tomoaki Matsuo, Hiroyuki Sasai, Miki Eto, Takehiko Tsujimoto, Kousaku Saotome and Kiyoji Tanaka

    Citation: Nutrition & Metabolism 2012 9:56

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  27. Content type: Research

    Limited data on sex differences in body composition changes in response to higher protein diets (PRO) compared to higher carbohydrate diets (CARB) suggest that a PRO diet helps preserve lean mass (LM) in women...

    Authors: Ellen M Evans, Mina C Mojtahedi, Matthew P Thorpe, Rudy J Valentine, Penny M Kris-Etherton and Donald K Layman

    Citation: Nutrition & Metabolism 2012 9:55

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  28. Content type: Research

    Dietary supplements containing L-arginine have been marketed with the purpose of increasing vasodilatation, and thus, blood and oxygen supply to the exercising muscle. The present study evaluated the acute eff...

    Authors: Thiago Silveira Alvares, Carlos Adam Conte-Junior, Joab Trajano Silva and Vânia Margaret Flosi Paschoalin

    Citation: Nutrition & Metabolism 2012 9:54

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  29. Content type: Research

    The expression of PDK4 is elevated by diabetes, fasting and other conditions associated with the switch from the utilization of glucose to fatty acids as an energy source. It is previously shown that peroxisom...

    Authors: Rita Rinnankoski-Tuikka, Mika Silvennoinen, Sira Torvinen, Juha J Hulmi, Maarit Lehti, Riikka Kivelä, Hilkka Reunanen and Heikki Kainulainen

    Citation: Nutrition & Metabolism 2012 9:53

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  30. Content type: Research

    Diets rich in omega-3 fatty acids and low in saturated fat were found beneficially associated with blood lipids and cardio-vascular health. Lean reindeer meet and local cold water white-fish species high in om...

    Authors: Natalia Petrenya, Magritt Brustad, Marie Cooper, Liliya Dobrodeeva, Fatima Bichkaeva, Gulnara Lutfalieva and Jon Øyvind Odland

    Citation: Nutrition & Metabolism 2012 9:51

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  31. Content type: Research

    The present study investigated plasma levels of gut-brain axis peptides ghrelin, obestatin, NPY and PYY after consumption of a high-carbohydrate (HC) and high-protein (HP) breakfast in patients with anorexia n...

    Authors: Dana Sedlackova, Jana Kopeckova, Hana Papezova, Vojtech Hainer, Hana Kvasnickova, Martin Hill and Jara Nedvidkova

    Citation: Nutrition & Metabolism 2012 9:52

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  32. Content type: Research

    Epidemiology and animal models suggest that dietary monosodium glutamate (MSG) may contribute to the onset of obesity and the metabolic syndrome.

    Authors: Tonkla Insawang, Carlo Selmi, Ubon Cha’on, Supattra Pethlert, Puangrat Yongvanit, Premjai Areejitranusorn, Patcharee Boonsiri, Tueanjit Khampitak, Roongpet Tangrassameeprasert, Chadamas Pinitsoontorn, Vitoon Prasongwattana, M Eric Gershwin and Bruce D Hammock

    Citation: Nutrition & Metabolism 2012 9:50

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  33. Content type: Research

    Whey protein increases postprandial serum insulin levels. This has been associated with increased serum levels of leucine, isoleucine, valine, lysine, threonine and the incretin hormone glucose-dependent insul...

    Authors: Albert Salehi, Ulrika Gunnerud, Sarheed J Muhammed, Elin Östman, Jens J Holst, Inger Björck and Patrik Rorsman

    Citation: Nutrition & Metabolism 2012 9:48

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  34. Content type: Research

    Folate, vitamin B-12, and vitamin B-6 are essential nutritional components in one-carbon metabolism and are required for methylation capacity. The availability of these vitamins may therefore modify methylatio...

    Authors: Nick van Wijk, Carol J Watkins, Robert J J Hageman, John C W Sijben, Patrick G H J Kamphuis, Richard J Wurtman and Laus M Broersen

    Citation: Nutrition & Metabolism 2012 9:49

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  35. Content type: Research

    Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia. However, the effect of the combi...

    Authors: Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, Noboru Mesaki, Ryuichi Ajisaka and Satoshi Fujita

    Citation: Nutrition & Metabolism 2012 9:47

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  36. Content type: Research

    The relationship between TSH and the lipid profile is contradictory because few studies have excluded the potential influence of the thyroid hormones (TH). The aim of the present study was to evaluate the rela...

    Authors: Chao Xu, Xiaomei Yang, Wenhui Liu, Haitao Yuan, Chunxiao Yu, Ling Gao and Jiajun Zhao

    Citation: Nutrition & Metabolism 2012 9:44

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  37. Content type: Research

    The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), especially in dyslipidemic subjects with a high risk of cardiovascular disease, are widely described in the literature. A lot of effec...

    Authors: Simone Schmidt, Frank Stahl, Kai-Oliver Mutz, Thomas Scheper, Andreas Hahn and Jan Philipp Schuchardt

    Citation: Nutrition & Metabolism 2012 9:45

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  38. Content type: Research

    Emerging evidence indicates that there is an association between vitamin D and obesity. The aim of this study was to investigate whether the level of serum 25-hydroxyvitamin D3 [25(OH)D3] in the elderly is influe...

    Authors: Alexandra Jungert, Heinz J Roth and Monika Neuhäuser-Berthold

    Citation: Nutrition & Metabolism 2012 9:42

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  39. Content type: Brief communication

    DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B12 and folate pathways are involved in the production of S-Adenosylmethionine, the ...

    Authors: Sílvia Fernàndez-Roig, Shao-Chiang Lai, Michelle M Murphy, Joan Fernandez-Ballart and Edward V Quadros

    Citation: Nutrition & Metabolism 2012 9:41

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  40. Content type: Review

    Provision of dietary amino acids increases skeletal muscle protein synthesis (MPS), an effect that is enhanced by prior resistance exercise. As a fundamentally necessary process in the enhancement of muscle ma...

    Authors: Tyler A Churchward-Venne, Nicholas A Burd and Stuart M Phillips

    Citation: Nutrition & Metabolism 2012 9:40

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  41. Content type: Research

    Nutritional manipulations during fetal growth may induce long-term metabolic effects in postnatal life. The aim of the study was to test whether combined treatment of pregnant sows with alpha-ketoglutarate and β-...

    Authors: Marcin R Tatara, Witold Krupski, Barbara Tymczyna and Tadeusz Studziński

    Citation: Nutrition & Metabolism 2012 9:39

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  42. Content type: Research

    We have reported a reduction in fatty acid oxidation (FAO) at the whole-body level and in skeletal muscle in severely obese (BMI ≥ 40 kg/m2) individuals; this defect is retained in cell culture suggesting an inhe...

    Authors: Audrey D Eaves, Ashley Colon, Katrina D DuBose, David Collier and Joseph A Houmard

    Citation: Nutrition & Metabolism 2012 9:38

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