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  1. Content type: Research

    Jerusalem artichoke (Helianthus tuberosus Linne, HTL) and chungkookjang (CKJ; fermented soybeans) both modulate energy and glucose metabolism. However, the mechanism and their additive effects are unknown. We inv...

    Authors: Hye Jeong Yang, Dae Young Kwon, Min Jung Kim, Suna Kang, Da Sol Kim and Sunmin Park

    Citation: Nutrition & Metabolism 2012 9:112

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  2. Content type: Research

    In Lebanon, Type 2 diabetes (T2D) has a major public health impact through high disease prevalence, significant downstream pathophysiologic effects, and enormous financial liabilities. Diet is an important env...

    Authors: Farah Naja, Nahla Hwalla, Leila Itani, Maya Salem, Sami T Azar, Maya Nabhani Zeidan and Lara Nasreddine

    Citation: Nutrition & Metabolism 2012 9:111

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  3. Content type: Research

    Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate ...

    Authors: Zhou Zhou, Manish Neupane, Hui Ren Zhou, Dayong Wu, Chia-Cheng Chang, Naima Moustaid-Moussa and Kate J Claycombe

    Citation: Nutrition & Metabolism 2012 9:109

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  4. Content type: Research

    High intakes of phytochemical-rich foods have favorable effects on the prevention of chronic diseases. In this study we assessed the dietary phytochemical index (PI) in relation to 3-year change in weight, wai...

    Authors: Parvin Mirmiran, Zahra Bahadoran, Mahdieh Golzarand, Niloofar Shiva and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2012 9:108

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  5. Content type: Research

    The study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in ...

    Authors: Hong-Zhu Deng, Hong Deng, Zhe Su, Yan-Hong Li, Hua-Mei Ma, Hong-Shan Chen and Min-Lian Du

    Citation: Nutrition & Metabolism 2012 9:107

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  6. Content type: Research

    Type 2 diabetes is associated with obesity, ectopic lipid accumulation and low-grade inflammation. A dysfunctional gut microbiota has been suggested to participate in the pathogenesis of the disease. Green tea...

    Authors: Ulrika Axling, Crister Olsson, Jie Xu, Céline Fernandez, Sara Larsson, Kristoffer Ström, Siv Ahrné, Cecilia Holm, Göran Molin and Karin Berger

    Citation: Nutrition & Metabolism 2012 9:105

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  7. Content type: Research

    As a cellular energy sensor, the 5’AMP-activated protein kinase (AMPK) is activated in response to energy stresses such as hypoxia and muscle contraction. To determine effects of iron deficiency on AMPK activa...

    Authors: John F Merrill, David M Thomson, Shalene E Hardman, Squire D Hepworth, Shelby Willie and Chad R Hancock

    Citation: Nutrition & Metabolism 2012 9:104

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  8. Content type: Research

    Inflammation and oxidative stress are associated with the development of numerous chronic diseases. Circulating ascorbic acid, α-tocopherol, and 25-hydroxyvitamin D (25(OH)D) may help reduce concentrations of ...

    Authors: Bibiana García-Bailo, Kaitlin Roke, David M Mutch, Ahmed El-Sohemy and Alaa Badawi

    Citation: Nutrition & Metabolism 2012 9:102

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  9. Content type: Research

    Obesity is a common pathology with increasing incidence, and is associated with increased mortality and healthcare costs. Several treatment options for obesity are currently available ranging from behavioral m...

    Authors: Roger A Vaughan, Randi Garcia-Smith, Miguel A Barberena, Marco Bisoffi, Kristina Trujillo and Carole A Conn

    Citation: Nutrition & Metabolism 2012 9:101

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  10. Content type: Research

    Diets producing a high glycemic response result in exaggerated insulin secretion which induces hepatic lipogenesis, contributing to development of insulin resistance and fatty liver. Viscous dietary fibers blu...

    Authors: David A Brockman, Xiaoli Chen and Daniel D Gallaher

    Citation: Nutrition & Metabolism 2012 9:100

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  11. Content type: Research

    Early age at menarche is associated with increased risk of metabolic syndrome in both China and the West. However, little is known about the impact of age at menarche and metabolic syndrome in South Asian wome...

    Authors: Shamima Akter, Subrina Jesmin, Mazedul Islam, Sayeeda Nusrat Sultana, Osamu Okazaki, Michiaki Hiroe, Masao Moroi and Taro Mizutani

    Citation: Nutrition & Metabolism 2012 9:99

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  12. Content type: Research

    The ability of an intermittent fasting (IF)-calorie restriction (CR) regimen (with or without liquid meals) to modulate adipokines in a way that is protective against coronary heart disease (CHD) has yet to be...

    Authors: Cynthia M Kroeger, Monica C Klempel, Surabhi Bhutani, John F Trepanowski, Christine C Tangney and Krista A Varady

    Citation: Nutrition & Metabolism 2012 9:98

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  13. Content type: Research

    The soluble cell adhesion molecules and adipokines are elevated in patients with obesity, hypertension, type 2 diabetes mellitus, breast cancer and atherosclerosis.

    Authors: Caroline Isoppo de Souza, Daniela Dornelles Rosa, Betina Ettrich, Gabriela Hermann Cibeira, Juliana Giacomazzi, Paloma Tusset, Patrícia Ashton-Prolla, Lidia Rosi Medeiros, Maira Caleffi, Eurico Camargo Neto, Emilio Hideyuki Moriguchi and Marcia Silveira Graudenz

    Citation: Nutrition & Metabolism 2012 9:97

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  14. Content type: Research

    Endocrine FGF19 and FGF21 exert their effects on metabolic homeostasis through fibroblast growth factor receptor (FGFR) and co-factor betaKlotho (KLB). Ileal FGF19 regulates bile acid metabolism through specif...

    Authors: Chaofeng Yang, Cong Wang, Min Ye, Chengliu Jin, Weimin He, Fen Wang, Wallace L McKeehan and Yongde Luo

    Citation: Nutrition & Metabolism 2012 9:94

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  15. Content type: Research

    Previous studies examining the metabolic consequences of dietary iron deficiency have reported elevated serum glucose concentrations in iron-deficient animals. Importantly, the majority of these findings were ...

    Authors: McKale R Davis, Kristen K Hester, Krista M Shawron, Edralin A Lucas, Brenda J Smith and Stephen L Clarke

    Citation: Nutrition & Metabolism 2012 9:95

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  16. Content type: Research

    Only protein diet has been used successfully to prevent loss of lean body mass first in post-surgical and then in obese patients. We studied overweight and obese patients receiving short treatments of an exclu...

    Authors: Gianfranco Cappello, Antonella Franceschelli, Annalisa Cappello and Paolo De Luca

    Citation: Nutrition & Metabolism 2012 9:96

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  17. Content type: Research

    Animal studies show that diets containing resistant starch (RS) at levels not achievable in the human diet result in lower body weight and/or adiposity in rodents. We aimed to determine whether RS dose-depende...

    Authors: Damien P Belobrajdic, Roger A King, Claus T Christophersen and Anthony R Bird

    Citation: Nutrition & Metabolism 2012 9:93

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  18. Content type: Research

    Adolescence is an important life stage for the development of dietary preferences and health behaviour. Longitudinal studies indicated that cardiovascular status in adolescence predicts cardiovascular risk mar...

    Authors: Julia Truthmann, Almut Richter, Silke Thiele, Larissa Drescher, Jutta Roosen and Gert BM Mensink

    Citation: Nutrition & Metabolism 2012 9:92

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  19. Content type: Brief communication

    The pattern of protein intake following exercise may impact whole-body protein turnover and net protein retention. We determined the effects of different protein feeding strategies on protein metabolism in res...

    Authors: Daniel R Moore, Jose Areta, Vernon G Coffey, Trent Stellingwerff, Stuart M Phillips, Louise M Burke, Marilyn Cléroux, Jean-Philippe Godin and John A Hawley

    Citation: Nutrition & Metabolism 2012 9:91

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  20. Content type: Brief communication

    Calorie restriction (CR; ~60% of ad libitum, AL intake) has been associated with substantial alterations in body composition and insulin sensitivity. Recently, several proteins that are secreted by nontraditio...

    Authors: Naveen Sharma, Carlos M Castorena and Gregory D Cartee

    Citation: Nutrition & Metabolism 2012 9:90

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  21. Content type: Review

    Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that include obesity, impaired glucose tolerance or diabetes, hyperinsulinemia, hypertension, and dyslipidemia. Recently, more attention ha...

    Authors: Enrico Marchetti, Annalisa Monaco, Laura Procaccini, Stefano Mummolo, Roberto Gatto, Stefano Tetè, Alberto Baldini, Simona Tecco and Giuseppe Marzo

    Citation: Nutrition & Metabolism 2012 9:88

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  22. Content type: Research

    It is difficult to study the mechanisms of the metabolic syndrome in humans due to the heterogeneous genetic background and lifestyle. The present study investigated changes in the gene and protein profiles in...

    Authors: Jie Chang, Shinji Oikawa, Gaku Ichihara, Yui Nanpei, Yasuhiro Hotta, Yoshiji Yamada, Saeko Tada-Oikawa, Hitoshi Iwahashi, Emiko Kitagawa, Ichiro Takeuchi, Masao Yuda and Sahoko Ichihara

    Citation: Nutrition & Metabolism 2012 9:87

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  23. Content type: Research

    DOR/TP53INP2 acts both at the chromosomal level as a nuclear co-factor e.g. for the thyroid hormone receptor and at the extrachromosomal level as an organizing factor of the autophagosome. In a previous study,...

    Authors: Carolin Fromm-Dornieden, Oleksandr Lytovchenko, Silvia von der Heyde, Nina Behnke, Sebastian Hogl, Janina Berghoff, Frederik Köpper, Lennart Opitz, Ulla Renne, Andreas Hoeflich, Tim Beissbarth, Bertram Brenig and Bernhard G Baumgartner

    Citation: Nutrition & Metabolism 2012 9:86

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  24. Content type: Research

    The prevalence of obesity is increasing exponentially world over. Leptin resistance/hyperleptinemia is attributed to its cause in majority of the obese humans where mutation in genetic component or ob gene has...

    Authors: Satish Kumar Taneja, Reshu Mandal and Aman Chechi

    Citation: Nutrition & Metabolism 2012 9:85

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  25. Content type: Research

    Oxidative stress plays an important role in diabetes-induced vascular inflammation and pathogenesis. Nuclear factor E2-related factor-2 (Nrf2) is a transcription factor orchestrating antioxidant and cyto-prote...

    Authors: Xiao Miao, Yang Bai, Weixia Sun, Wenpeng Cui, Ying Xin, Yuehui Wang, Yi Tan, Lining Miao, Yaowen Fu, Guanfang Su and Lu Cai

    Citation: Nutrition & Metabolism 2012 9:84

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  26. Content type: Review

    Caloric restriction is one of the most efficient ways to promote weight loss and is known to activate protective metabolic pathways. Frequently reported with weight loss is the undesirable consequence of fat f...

    Authors: Cassandra M McIver, Thomas P Wycherley and Peter M Clifton

    Citation: Nutrition & Metabolism 2012 9:83

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  27. Content type: Research

    The Daniel Fast is a vegan diet that prohibits the consumption of animal products, refined foods, white flour, preservatives, additives, sweeteners, flavorings, caffeine, and alcohol. Following this dietary pl...

    Authors: John F Trepanowski, Mohammad M Kabir, Rick J Alleman Jr and Richard J Bloomer

    Citation: Nutrition & Metabolism 2012 9:82

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  28. Content type: Review

    Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism. In contrast to protein restriction during fetal lif...

    Authors: Júlio Cezar de Oliveira, Sabrina Grassiolli, Clarice Gravena and Paulo Cezar Freitas de Mathias

    Citation: Nutrition & Metabolism 2012 9:80

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  29. Content type: Research

    Dietary glycemic index or load is thought to play an important role in glucose metabolism. However, few studies have investigated the relation between glycemic index (GI) or load (GL) and glycemia in Asian pop...

    Authors: Maki Goto, Akemi Morita, Atsushi Goto, Satoshi Sasaki, Naomi Aiba, Takuro Shimbo, Yasuo Terauchi, Motohiko Miyachi, Mitsuhiko Noda and Shaw Watanabe

    Citation: Nutrition & Metabolism 2012 9:79

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  30. Content type: Research

    In humans, skipping meals, especially breakfast, has been associated with obesity and other related syndromes. Recent studies in rodents suggest that fasting and feeding times are potential factors that affect...

    Authors: Chika Yoshida, Nahoko Shikata, Shinobu Seki, Naoto Koyama and Yasushi Noguchi

    Citation: Nutrition & Metabolism 2012 9:78

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  31. Content type: Research

    Sirtuins are important regulators of glucose and fat metabolism, and sirtuin activation has been proposed as a therapeutic target for insulin resistance and diabetes. We have shown leucine to increase mitochon...

    Authors: Antje Bruckbauer, Michael B Zemel, Teresa Thorpe, Murthy R Akula, Alan C Stuckey, Dustin Osborne, Emily B Martin, Stephen Kennel and Jonathan S Wall

    Citation: Nutrition & Metabolism 2012 9:77

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  32. Content type: Research

    The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.

    Authors: Mireia Olivan, Jochen Springer, Sílvia Busquets, Anika Tschirner, Maite Figueras, Miriam Toledo, Cibely Fontes-Oliveira, Maria Inés Genovese, Paula Ventura da Silva, Angelica Sette, Francisco J López-Soriano, Stefan Anker and Josep M Argilés

    Citation: Nutrition & Metabolism 2012 9:76

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  33. Content type: Review

    Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth signaling. The nutrient-sensitive kinase mTORC1 is upre...

    Authors: Bodo C Melnik, Swen Malte John, Pedro Carrera-Bastos and Loren Cordain

    Citation: Nutrition & Metabolism 2012 9:74

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  34. Content type: Research

    Visceral fat accumulation is one of the most important predictors of mortality in obese populations. Administration of green tea extract (GTE) can reduce body fat and reduce the risk of obesity-related disease...

    Authors: Takahiro Hasumura, Yasuhito Shimada, Junya Kuroyanagi, Yuhei Nishimura, Shinichi Meguro, Yoshinori Takema and Toshio Tanaka

    Citation: Nutrition & Metabolism 2012 9:73

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  35. Content type: Research

    There is growing evidence that dietary antioxidants could have favorable effects on the attenuation and prevention of metabolic disorders. In the current study we investigated the association of dietary total ...

    Authors: Zahra Bahadoran, Mahdieh Golzarand, Parvin Mirmiran, Niloofar Shiva and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2012 9:70

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  36. Content type: Review

    Sphingolipids are ubiquitous and critical components of biological membranes. Their biosynthesis starts with soluble precursors in the endoplasmic reticulum and culminates in the Golgi complex and plasma membr...

    Authors: M Mahmood Hussain, Weijun Jin and Xian-Cheng Jiang

    Citation: Nutrition & Metabolism 2012 9:71

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  37. Content type: Research

    High fat feeding in rodents generally leads to obesity and insulin resistance whereas in humans this is only seen if dietary carbohydrate is also high, the result of the anabolic effect of poor regulation of g...

    Authors: Saihan Borghjid and Richard David Feinman

    Citation: Nutrition & Metabolism 2012 9:69

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  38. Content type: Research

    Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effec...

    Authors: Chad L Cox, Kimber L Stanhope, Jean Marc Schwarz, James L Graham, Bonnie Hatcher, Steven C Griffen, Andrew A Bremer, Lars Berglund, John P McGahan, Nancy L Keim and Peter J Havel

    Citation: Nutrition & Metabolism 2012 9:68

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  39. Content type: Research

    Leucine (Leu) regulates muscle protein synthesis (MPS) producing dose-dependent plasma Leu and MPS responses from free amino acid solutions. This study examined the role of Leu content from dietary proteins in...

    Authors: Layne E Norton, Gabriel J Wilson, Donald K Layman, Christopher J Moulton and Peter J Garlick

    Citation: Nutrition & Metabolism 2012 9:67

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  40. Content type: Research

    Genome-wide association studies (GWAS) have recently identified several new genetic variants associated with obesity. The majority of the variants are within introns or between genes, suggesting they affect ge...

    Authors: Piriya Yoganathan, Subashini Karunakaran, Maggie M Ho and Susanne M Clee

    Citation: Nutrition & Metabolism 2012 9:65

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  41. Content type: Research

    Obesity associates with low-grade inflammation and adipose tissue remodeling. Using sensitive high-throughput protein arrays we here investigated adipose tissue cytokine and angiogenesis-related protein profil...

    Authors: Eveliina Kurki, Jin Shi, Essi Martonen, Piet Finckenberg and Eero Mervaala

    Citation: Nutrition & Metabolism 2012 9:64

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