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  1. The expression of leptin is increased in obesity and inhibited by n-3 polyunsaturated fatty acids (n-3 PUFAs), but the underlying molecular mechanisms have not been firmly established.

    Authors: Chaonan Fan, Xinli Liu, Wenwen Shen, Richard J Deckelbaum and Kemin Qi
    Citation: Nutrition & Metabolism 2011 8:31
  2. Adipocyte volume (fat accumulation) and cell number (adipogenesis) is increased in obese individuals. Our objective was the identification of dietary constituents with inhibitory effects on triglyceride format...

    Authors: Ines Warnke, Regina Goralczyk, Erna Fuhrer and Joseph Schwager
    Citation: Nutrition & Metabolism 2011 8:30
  3. A remarkable range of biological functions have been ascribed to resveratrol. Recently, this polyphenol has been shown to have body fat lowering effects. The aim of the present study was to assess some of the ...

    Authors: Goiuri Alberdi, Víctor M Rodríguez, Jonatan Miranda, María T Macarulla, Noemí Arias, Cristina Andrés-Lacueva and María P Portillo
    Citation: Nutrition & Metabolism 2011 8:29
  4. Chromium (Cr) is an essential trace element that has garnered interest for use as a weight loss aid, but its molecular mechanism in obesity is not clear. In this study, an attempt has been made to investigate ...

    Authors: Mehmet Tuzcu, Nurhan Sahin, Cemal Orhan, Can Ali Agca, Fatih Akdemir, Zeynep Tuzcu, James Komorowski and Kazim Sahin
    Citation: Nutrition & Metabolism 2011 8:28
  5. The potential of cereals with high antioxidant capacity for reducing oxidative stress and inflammation in obesity is unknown. This study investigated the impact of wheat bran, barley or a control diet (α-cellu...

    Authors: Damien P Belobrajdic, Yan Y Lam, Mark Mano, Gary A Wittert and Anthony R Bird
    Citation: Nutrition & Metabolism 2011 8:27
  6. Inadequate energy intake induces changes in endogenous glucose production (GP) to preserve muscle mass. Whether addition provision of dietary protein modulates GP response to energy deficit is unclear. The obj...

    Authors: Tracey J Smith, Jean-Marc Schwarz, Scott J Montain, Jennifer Rood, Matthew A Pikosky, Carmen Castaneda-Sceppa, Ellen Glickman and Andrew J Young
    Citation: Nutrition & Metabolism 2011 8:26
  7. Sphingomyelin (SM) is an abundant phospholipid in cell membranes and in lipoproteins. In human plasma, SM is mainly found in atherogenic lipoproteins; therefore, higher levels of SM may promote atherogenesis. ...

    Authors: Xueying Chen, Aijun Sun, Yunzeng Zou, Junbo Ge, Jason M Lazar and Xian-Cheng Jiang
    Citation: Nutrition & Metabolism 2011 8:25
  8. We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy K...

    Authors: Oh Yoen Kim, Hyo Hee Lim, Long In Yang, Jey Sook Chae and Jong Ho Lee
    Citation: Nutrition & Metabolism 2011 8:24
  9. Familial Hypercholesterolemia (FH) is a common cause of premature cardiovascular disease and is often undiagnosed in young people. Although the disease is diagnosed clinically by high LDL cholesterol levels an...

    Authors: Akl C Fahed and Georges M Nemer
    Citation: Nutrition & Metabolism 2011 8:23
  10. The use of lipid emulsions has been associated with changes in lung function and gas exchange which may be mediated by biologically active metabolites derived from arachidonic acid. The type and quantity of th...

    Authors: Joan Sabater, Joan Ramon Masclans, Judit Sacanell, Pilar Chacon, Pilar Sabin and Mercè Planas
    Citation: Nutrition & Metabolism 2011 8:22
  11. Medium-chain triacylglycerols (MCT), omega-3 polyunsaturated fatty acids (n-3-PUFA) and micronutrients may be useful for weight and cardiometabolic risk management. However, studies analyzing the effect of a c...

    Authors: Roswitha Siener, Christina Ehrhardt, Norman Bitterlich and Christine Metzner
    Citation: Nutrition & Metabolism 2011 8:21
  12. Glycated albumin (GA) is an Amadori product used as a marker of hyperglycemia. In this study, we investigated the effect of GA on insulin secretion from pancreatic β cells.

    Authors: Takayuki Shiraki, Yoshikazu Miura, Tokihiko Sawada, Toshie Okada, Yuhki Sakuraoka, Takashi Muto and Keiichi Kubota
    Citation: Nutrition & Metabolism 2011 8:20
  13. Inflammation, the key regulator of C-reactive protein (CRP) synthesis, plays a pivotal role in atherothrombotic cardiovascular disease.

    Authors: Panniyammakal Jeemon, Dorairaj Prabhakaran, Lakhmy Ramakrishnan, Ruby Gupta, F Ahmed, KR Thankappan, CC Kartha, Vivek Chaturvedi and KS Reddy
    Citation: Nutrition & Metabolism 2011 8:19
  14. Quercetin derivatives in onions have been regarded as the most important flavonoids to improve diabetic status in cells and animal models. The present study was aimed to examine the hypoglycemic and insulin-se...

    Authors: Ji Young Jung, Yeni Lim, Min Sun Moon, Ji Yeon Kim and Oran Kwon
    Citation: Nutrition & Metabolism 2011 8:18
  15. Dietary modification via both caloric and nutrient restriction is associated with multiple health benefits, some of which are related to an improvement in antioxidant status and a decrease in the production of...

    Authors: Richard J Bloomer, Mohammad M Kabir, John F Trepanowski, Robert E Canale and Tyler M Farney
    Citation: Nutrition & Metabolism 2011 8:17
  16. Systemic chronic inflammation is linked to metabolic syndrome, type-2 diabetes, and heart disease. Lipopolysaccharide (LPS), a Gram negative microbial product, triggers inflammation through toll-like-receptor-...

    Authors: Matam Vijay-Kumar, Sally M Vanegas, Nilam Patel, Jesse D Aitken, Thomas R Ziegler and Vijay Ganji
    Citation: Nutrition & Metabolism 2011 8:16
  17. Minimizing the number of muscle biopsies has important methodological implications and minimizes subject discomfort during a stable isotope amino acid infusion. We aimed to determine the reliability of obtaini...

    Authors: Nicholas A Burd, Daniel WD West, Tracy Rerecich, Todd Prior, Steven K Baker and Stuart M Phillips
    Citation: Nutrition & Metabolism 2011 8:15
  18. Obesity and metabolic syndrome are important public concerns, and there is increasing demand for effective therapeutic strategies. Flavonoids are expected to improve the risk factors associated with metabolic ...

    Authors: Rieko Suzuki, Masami Tanaka, Masakatsu Takanashi, Aashiq Hussain, Bo Yuan, Hiroo Toyoda and Masahiko Kuroda
    Citation: Nutrition & Metabolism 2011 8:14
  19. β-Hydroxy-β-methylbutyrate (HMβ) supplementation is used to treat cancer, sepsis and exercise-induced muscle damage. However, its effects on animal and human health and the consequences of this treatment in ot...

    Authors: Gustavo D Pimentel, José C Rosa, Fábio S Lira, Nelo E Zanchi, Eduardo R Ropelle, Lila M Oyama, Cláudia M Oller do Nascimento, Marco Túlio de Mello, Sergio Tufik and Ronaldo VT Santos
    Citation: Nutrition & Metabolism 2011 8:11
  20. Coffee consumption is associated with a lower risk of type 2 diabetes. We tested the hypothesis that this is mediated by incretin hormones by measuring the acute effects of decaffeinated coffee and coffee comp...

    Authors: Margreet R Olthof, Aimée E van Dijk, Carolyn F Deacon, Robert J Heine and Rob M van Dam
    Citation: Nutrition & Metabolism 2011 8:10
  21. Reducing dietary energy density has proven to be an effective strategy to reduce energy intakes and promote weight control. This effect appears most robust when a low energy dense preload is consumed before me...

    Authors: Heidi J Silver, Mary S Dietrich and Kevin D Niswender
    Citation: Nutrition & Metabolism 2011 8:8
  22. We have previously shown that krill oil (KO), more efficiently than fish oil, was able to downregulate the endocannabinoid system in different tissues of obese zucker rats.

    Authors: Sebastiano Banni, Gianfranca Carta, Elisabetta Murru, Lina Cordeddu, Elena Giordano, Anna Rita Sirigu, Kjetil Berge, Hogne Vik, Kevin C Maki, Vincenzo Di Marzo and Mikko Griinari
    Citation: Nutrition & Metabolism 2011 8:7
  23. Nut consumption may reduce the risk of developing type 2 diabetes. The aim of the current study was to measure the acute and second-meal effects of morning almond consumption and determine the contribution of ...

    Authors: Alisa M Mori, Robert V Considine and Richard D Mattes
    Citation: Nutrition & Metabolism 2011 8:6
  24. Higher fish or higher docosahexaenoic acid (DHA) intake normally correlates positively with higher plasma DHA level, but recent evidence suggests that the positive relationship between intake and plasma levels...

    Authors: Mélanie Plourde, Raphaël Chouinard-Watkins, Milène Vandal, Ying Zhang, Peter Lawrence, J Thomas Brenna and Stephen C Cunnane
    Citation: Nutrition & Metabolism 2011 8:5
  25. The central feature of NAFLD is a disturbed fatty-acid metabolism with hepatic lipid accumulation. However, the factors that determine the severity of NAFLD, including the role of nutrition, gender, and plasma...

    Authors: Tine M Comhair, Sonia C Garcia Caraballo, Cornelis HC Dejong, Wouter H Lamers and S Eleonore Köhler
    Citation: Nutrition & Metabolism 2011 8:4
  26. Metabolic syndrome (MetS) is associated with an increased risk of the development of atherosclerotic cardiovascular disease (CVD). Interleukin-18 (IL-18), which is a pleiotropic proinflammatory cytokine with i...

    Authors: Minako Yamaoka-Tojo, Taiki Tojo, Kazuki Wakaume, Ryo Kameda, Shinji Nemoto, Naonobu Takahira, Takashi Masuda and Tohru Izumi
    Citation: Nutrition & Metabolism 2011 8:3
  27. Current notions about mechanisms by which catch-up growth predisposes to later type 2 diabetes center upon those that link hyperinsulinemia with an accelerated rate of fat deposition (catch-up fat). Using a ra...

    Authors: Marina Casimir, Paula B de Andrade, Asllan Gjinovci, Jean-Pierre Montani, Pierre Maechler and Abdul G Dulloo
    Citation: Nutrition & Metabolism 2011 8:2
  28. Obesity and osteoporosis, two possibly related conditions, are rapidly expanding health concerns in modern society. Both of them are associated with sedentary life style and nutrition. To investigate the effec...

    Authors: Hongqiang Ma, Tuomas Turpeinen, Mika Silvennoinen, Sira Torvinen, Rita Rinnankoski-Tuikka, Heikki Kainulainen, Jussi Timonen, Urho M Kujala, Paavo Rahkila and Harri Suominen
    Citation: Nutrition & Metabolism 2011 8:1
  29. Milk phospholipids (PLs) reduce liver lipid levels when given as a dietary supplement to mice fed a high-fat diet. We have speculated that this might be due to reduced intestinal cholesterol uptake.

    Authors: Alvin Kamili, Elaine Wat, Rosanna WS Chung, Sally Tandy, Jacquelyn M Weir, Peter J Meikle and Jeffrey S Cohn
    Citation: Nutrition & Metabolism 2010 7:90
  30. Golden-Syrian hamsters have been used as an animal model to assess diet-induced atherosclerosis since the early 1980s. Advantages appeared to include a low rate of endogenous cholesterol synthesis, receptor-me...

    Authors: Alice Dillard, Nirupa R Matthan and Alice H Lichtenstein
    Citation: Nutrition & Metabolism 2010 7:89
  31. The prevalence of type 2 diabetes is increasing worldwide, accounting for 85-95% of all diagnosed cases of diabetes. Clinical trials provide evidence of benefits of low-carbohydrate ketogenic diets in terms of...

    Authors: Judith Farrés, Albert Pujol, Mireia Coma, Jose Luis Ruiz, Jordi Naval, José Manuel Mas, Agustí Molins, Joan Fondevila and Patrick Aloy
    Citation: Nutrition & Metabolism 2010 7:88
  32. Most of the human population in the western world has access to unlimited calories and leads an increasingly sedentary lifestyle. The propensity to undertake voluntary exercise or indulge in spontaneous physic...

    Authors: Alistair V Nunn, Geoffrey W Guy, James S Brodie and Jimmy D Bell
    Citation: Nutrition & Metabolism 2010 7:87
  33. Increased visceral adipose tissue (VAT) and intramyocellular lipids (IMCL) are associated with increased metabolic risk. Clinical and DXA body composition measures that are associated with VAT are generally ev...

    Authors: Eray Savgan-Gurol, Miriam Bredella, Melissa Russell, Nara Mendes, Anne Klibanski and Madhusmita Misra
    Citation: Nutrition & Metabolism 2010 7:86
  34. We found marked improvement of glucose tolerance and lower dietary energy intake in ischemic heart disease (IHD) patients after advice to follow a Paleolithic diet, as compared to a Mediterranean-like diet. We...

    Authors: Tommy Jönsson, Yvonne Granfeldt, Charlotte Erlanson-Albertsson, Bo Ahrén and Staffan Lindeberg
    Citation: Nutrition & Metabolism 2010 7:85
  35. Individuals who smoke generally have a lower body mass index (BMI) than nonsmokers. The relative roles of energy expenditure and energy intake in maintaining the lower BMI, however, remain controversial. We te...

    Authors: David P Bradley, Lindsey A Johnson, Zhumin Zhang, Amy F Subar, Richard P Troiano, Arthur Schatzkin and Dale A Schoeller
    Citation: Nutrition & Metabolism 2010 7:81
  36. Olive oil's beneficial effects are not only related to its high content of oleic acid, but also to the antioxidant potential of its polyphenols. In this study, we assess the effects of virgin olive oil and its...

    Authors: Amel Nakbi, Wafa Tayeb, Abir Grissa, Manel Issaoui, Samia Dabbou, Issam Chargui, Meriem Ellouz, Abdelhedi Miled and Mohamed Hammami
    Citation: Nutrition & Metabolism 2010 7:80
  37. Chronic fatigue syndrome (CFS) is a debilitating disease characterized by unexplained disabling fatigue and a combination of accompanying symptoms the pathology of which is incompletely understood. Many CFS pa...

    Authors: Shaheen E Lakhan and Annette Kirchgessner
    Citation: Nutrition & Metabolism 2010 7:79
  38. Dihydrocapsiate (DCT) is a natural safe food ingredient which is structurally related to capsaicin from chili pepper and is found in the non-pungent pepper strain, CH-19 Sweet. It has been shown to elicit the ...

    Authors: TszYing Amy Lee, Zhaoping Li, Alona Zerlin and David Heber
    Citation: Nutrition & Metabolism 2010 7:78
  39. Early dietary exposure can influence susceptibility to obesity and type 2 diabetes later in life. We examined the lasting effects of a high protein or high prebiotic fiber weaning diet when followed by a high ...

    Authors: Alannah D Maurer, Lindsay K Eller, Megan C Hallam, Kim Taylor and Raylene A Reimer
    Citation: Nutrition & Metabolism 2010 7:77
  40. As hyperlipidemia, including hypercholesterolemia (HC) and hypertriglyceridemia (HTN), continue to challenge North America's healthcare systems, patients continue to seek efficacious and safe natural therapies...

    Authors: Christopher PF Marinangeli and Peter JH Jones
    Citation: Nutrition & Metabolism 2010 7:76
  41. Estrogen or phytoestrogens treatment has been suggested to improve cognitive function of the brain in postmenopausal women. However, there is lack of information on the mechanism of such treatment on the centr...

    Authors: Meixia Pan, Zhuoneng Li, Victor Yeung and Ruo-Jun Xu
    Citation: Nutrition & Metabolism 2010 7:75
  42. Malignant brain tumors affect people of all ages and are the second leading cause of cancer deaths in children. While current treatments are effective and improve survival, there remains a substantial need for...

    Authors: Phillip Stafford, Mohammed G Abdelwahab, Do Young Kim, Mark C Preul, Jong M Rho and Adrienne C Scheck
    Citation: Nutrition & Metabolism 2010 7:74
  43. Bile acids (BA) have recently been shown to increase energy expenditure in mice, but this concept has not been tested in humans. Therefore, we investigated the relationship between plasma BA levels and energy ...

    Authors: Gemma Brufau, Matthias J Bahr, Bart Staels, Thierry Claudel, Johann Ockenga, Klaus HW Böker, Elizabeth J Murphy, Kris Prado, Frans Stellaard, Michael P Manns, Folkert Kuipers and Uwe JF Tietge
    Citation: Nutrition & Metabolism 2010 7:73

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