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  1. Content type: Research

    Arginine is an amino acid determinant in the metabolic, immune and reparative responses to severe trauma. The present study aims to determine argininemia and plasma arginine bioavailability (PAB) in critical t...

    Authors: Beatriz P. Costa, Paulo Martins, Carla Veríssimo, Marta Simões, Marisa Tomé, Manuela Grazina, Jorge Pimentel and Francisco Castro-Sousa

    Citation: Nutrition & Metabolism 2016 13:60

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  2. Content type: Research

    Free fatty acids (FFAs) acutely stimulate insulin secretion from pancreatic islets. Conflicting results have been presented regarding this effect at non-stimulatory glucose concentration, however. The aim of o...

    Authors: Jing Cen, Ernest Sargsyan and Peter Bergsten

    Citation: Nutrition & Metabolism 2016 13:59

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  3. Content type: Research

    Transplanting a fecal sample from lean, healthy donors to obese recipients has been shown to improve metabolic syndrome symptoms. We therefore examined the gut microbiota in mice after administering a long-ter...

    Authors: Maria Kulecka, Agnieszka Paziewska, Natalia Zeber-Lubecka, Filip Ambrozkiewicz, Michal Kopczynski, Urszula Kuklinska, Kazimiera Pysniak, Marta Gajewska, Michal Mikula and Jerzy Ostrowski

    Citation: Nutrition & Metabolism 2016 13:57

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  4. Content type: Research

    Folate deficiency is closely related to the development of neural tube defects (NTDs). However, the exact mechanism is not completely understood. This study aims to induce murine NTDs by inhibiting one of the ...

    Authors: Lin Xu, Li Wang, JianHua Wang, ZhiQiang Zhu, Ge Chang, Ying Guo, XinLi Tian and Bo Niu

    Citation: Nutrition & Metabolism 2016 13:56

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  5. Content type: Research

    Maternal obesity may program the fetus and increase the susceptibility of the offspring to adult diseases. Metformin crosses the placenta and has been associated with decreased inflammation and reversal of fat...

    Authors: Kemoy Harris, Neeraj Desai, Madhu Gupta, Xiangying Xue, Prodyot K. Chatterjee, Burton Rochelson and Christine N. Metz

    Citation: Nutrition & Metabolism 2016 13:55

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  6. Content type: Research

    2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a heterocyclic aromatic amine (HCA) formed in meat that is cooked at high temperatures and then ingested, can potentially be retained in human adipose ti...

    Authors: Lora J. Rogers, Alexei G. Basnakian, Mohammed S. Orloff, Baitang Ning, Aiwei Yao-Borengasser, Vinay Raj and Susan Kadlubar

    Citation: Nutrition & Metabolism 2016 13:54

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  7. Content type: Research

    Nonalcoholic fatty liver disease (NAFLD) is one of the health problems with great burden on the liver that may end with liver cirrhosis and hepatocellular carcinoma. The aim of this work was to assess serum vi...

    Authors: Amal Mohamed Ahmed, Maha Abdel Ghany, Gehan Lotfy Abdel Hakeem, Aya Kamal, Rania Khattab, Asmaa Abdalla, Laila El Morsi Abou El Fotoh, Abdel Azeem El Mazary, Madiha Abdalla Sayed and Ashraf Mohamed Abdel Fadil

    Citation: Nutrition & Metabolism 2016 13:53

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    The Erratum to this article has been published in Nutrition & Metabolism 2016 13:83

  8. Content type: Research

    Dysfunctional mitochondrial processes limit malignant cells ability to use energy from fatty acids and ketones. Animal studies using ketogenic diets for cancer show encouraging results. We tested the diet’s sa...

    Authors: Jocelyn L. Tan-Shalaby, Jennifer Carrick, Krystal Edinger, Dana Genovese, Andrew D. Liman, Vida A. Passero and Rashmikant B. Shah

    Citation: Nutrition & Metabolism 2016 13:52

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    The Erratum to this article has been published in Nutrition & Metabolism 2016 13:61

  9. Content type: Research

    Non-alcoholic fatty liver disease (NAFLD) and dyslipidemia are closely related. Diet plays an important role in the progression of these diseases, but the role of specific dietary components is not completely ...

    Authors: David Højland Ipsen, Pernille Tveden-Nyborg, Bidda Rolin, Günaj Rakipovski, Maria Beck, Line Winther Mortensen, Lasse Færk, Peter Mikael Helweg Heegaard, Peter Møller and Jens Lykkesfeldt

    Citation: Nutrition & Metabolism 2016 13:51

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  10. Content type: Review

    Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydro...

    Authors: Shahida A. Khan, Ghazi Damanhouri, Ashraf Ali, Sarah A. Khan, Aziz Khan, Ahmed Bakillah, Samy Marouf, Ghazi Al Harbi, Saeed H. Halawani and Ahmad Makki

    Citation: Nutrition & Metabolism 2016 13:50

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  11. Content type: Research

    Intestinal absorption of dietary lipids involves their hydrolysis in the lumen of proximal intestine as well as uptake, intracellular transport and re-assembly of hydrolyzed lipids in enterocytes, leading to t...

    Authors: Zeina Soayfane, François Tercé, Michela Cantiello, Horst Robenek, Michel Nauze, Valérie Bézirard, Sophie Allart, Bruno Payré, Florence Capilla, Christel Cartier, Christine Peres, Talal Al Saati, Vassilia Théodorou, David W. Nelson, Chi-Liang Eric Yen, Xavier Collet…

    Citation: Nutrition & Metabolism 2016 13:48

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  12. Content type: Research

    We recently have reported the 24-hour glucose, insulin and glucagon responses to a 72-hour fast compared to a 72-hour macronutrient-sufficient, carbohydrate-free diet in men with type 2 diabetes. The 72-hour t...

    Authors: Frank Quentin Nuttall, Rami Mahmoud Almokayyad and Mary Carol Gannon

    Citation: Nutrition & Metabolism 2016 13:47

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  13. Content type: Research

    The human SLC30A8 gene encodes the secretory granule-localised zinc transporter ZnT8 whose expression is chiefly restricted to the endocrine pancreas. Single nucleotide polymorphisms (SNPs) in the human SLC30A8 g...

    Authors: Antonia Solomou, Erwann Philippe, Pauline Chabosseau, Stephanie Migrenne-Li, Julien Gaitan, Jochen Lang, Christophe Magnan and Guy A. Rutter

    Citation: Nutrition & Metabolism 2016 13:46

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  14. Content type: Research

    The purpose of this study was to investigate the mitochondrial effects exerted by physiological and supra-physiological concentrations of recombinant human growth hormone (rhGH) and recombinant insulin-like gr...

    Authors: James Keane, Lotti Tajouri and Bon Gray

    Citation: Nutrition & Metabolism 2016 13:45

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  15. Content type: Research

    Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which ...

    Authors: Caio Yogi Yonamine, Erika Pinheiro-Machado, Maria Luiza Michalani, Helayne Soares Freitas, Maristela Mitiko Okamoto, Maria Lucia Corrêa-Giannella and Ubiratan Fabres Machado

    Citation: Nutrition & Metabolism 2016 13:44

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  16. Content type: Research

    Data regarding the impact of different lipid measures on cardiovascular diseases (CVD) and mortality events is not consistent. We aimed to evaluate the relationship between different lipid parameters and incid...

    Authors: Zahra Ghasemzadeh, Hengameh Abdi, Samaneh Asgari, Maryam Tohidi, Davood Khalili, Majid Valizadeh, Siamak Moeini, Vahid Eidkhani, Fereidoun Azizi and Farzad Hadaegh

    Citation: Nutrition & Metabolism 2016 13:43

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  17. Content type: Perspective

    Milk is rich in miRNAs that appear to play important roles in the postnatal development of all mammals. Currently, two competing hypotheses exist: the functional hypothesis, which proposes that milk miRNAs are tr...

    Authors: Bodo C. Melnik, Foteini Kakulas, Donna T. Geddes, Peter E. Hartmann, Swen Malte John, Pedro Carrera-Bastos, Loren Cordain and Gerd Schmitz

    Citation: Nutrition & Metabolism 2016 13:42

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  18. Content type: Erratum

    Authors: Karani S. Vimaleswaran, Dhanasekaran Bodhini, N. Lakshmipriya, K. Ramya, R. Mohan Anjana, Vasudevan Sudha, Julie A. Lovegrove, Sanjay Kinra, Viswanathan Mohan and Venkatesan Radha

    Citation: Nutrition & Metabolism 2016 13:41

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    The original article was published in Nutrition & Metabolism 2016 13:39

  19. Content type: Research

    The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus.

    Authors: Nuria Alcubierre, Eva M. Navarrete-Muñoz, Esther Rubinat, Mireia Falguera, Joan Valls, Alicia Traveset, Maria-Belen Vilanova, Josep Ramon Marsal, Marta Hernandez, Minerva Granado-Casas, Dolores Martinez-Gonzalez, Carmen Jurjo, Josep Franch-Nadal, Jesús Vioque and Didac Mauricio

    Citation: Nutrition & Metabolism 2016 13:40

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  20. Content type: Research

    Lifestyle factors such as diet and physical activity have been shown to modify the association between fat mass and obesity–associated (FTO) gene variants and metabolic traits in several populations; however, the...

    Authors: Karani S. Vimaleswaran, Dhanasekaran Bodhini, N. Lakshmipriya, K. Ramya, R. Mohan Anjana, Vasudevan Sudha, Julie A. Lovegrove, Sanjay Kinra, Viswanathan Mohan and Venkatesan Radha

    Citation: Nutrition & Metabolism 2016 13:39

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    The Erratum to this article has been published in Nutrition & Metabolism 2016 13:41

  21. Content type: Research

    The melanocortin-4 receptor (MC4R) regulates metabolism by modulating eating behavior and MC4R variants (rs17782313 and rs571312) are associated with obesity in Asians and Caucasians. However, the impact of th...

    Authors: Sunmin Park, James W. Daily, Xin Zhang, Hyun Seok Jin, Hye Ja Lee and Yong Hyun Lee

    Citation: Nutrition & Metabolism 2016 13:38

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  22. Content type: Research

    Serum Gamma-Glutamyl Transferase (GGT), a marker of oxidative stress, has been suggested to be independently associated with cardiovascular disease (CVD) events. We examined the association of serum GGT levels...

    Authors: Shozab S. Ali, Ebenezer T. Oni, Michael J. Blaha, Emir Veledar, Hamid R. Feiz, Theodore Feldman, Arthur S. Agatston, Roger S. Blumenthal, Raquel D. Conceicao, Jose A. M. Carvalho, Raul D. Santos and Khurram Nasir

    Citation: Nutrition & Metabolism 2016 13:37

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  23. Content type: Research

    Serum preβ1-high density lipoprotein (preβ1-HDL) was defined by two-dimensional non-denaturing linear gel electrophoresis and apolipoprotein A-I immuno-blotting. Serum preβ1-HDL seems to play an important role...

    Authors: Yunqin Chen, Jibin Dong, Xueying Chen, Hui Jiang, Ahmed Bakillah, Xiaojin Zhang, Zhiqiang Li, Jia Yin, Donghui Liang, Yunzeng Zou, Mahmood Hussain, Marina Cuchel, Daniel Rader, Haozhu Chen, Junbo Ge and Xian-Cheng Jiang

    Citation: Nutrition & Metabolism 2016 13:36

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  24. Content type: Research

    Controversial data is available on the effect of the Melanocortin-4 receptor (MC4R) gene variation on metabolic syndrome (MetS) and ineffectiveness of diet in managing MetS. Effects of the interaction between ...

    Authors: Gelareh Koochakpoor, Maryam S. Daneshpour, Parvin Mirmiran, Seyed Ahmad Hosseini, Firoozeh Hosseini-Esfahani, Bahareh Sedaghatikhayat and Fereidoun Azizi

    Citation: Nutrition & Metabolism 2016 13:35

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  25. Content type: Research

    Insulin-stimulated muscle blood flow facilitates plasma glucose disposal after a meal, a mechanism that is impaired in obese, insulin-resistant volunteers. Nitrate- or flavonoid-rich products, through their pr...

    Authors: Dagmar Fuchs, Jean Nyakayiru, Richard Draijer, Theo P. J. Mulder, Maria T. E. Hopman, Thijs M. H. Eijsvogels and Dick H. Thijssen

    Citation: Nutrition & Metabolism 2016 13:34

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  26. Content type: Research

    Metabolic abnormalities are more associated with central obesity than peripheral obesity, but the underlying mechanisms are largely unknown. The present study was to identify serum metabolic biomarkers which d...

    Authors: Xiang Gao, Weidong Zhang, Yongbo Wang, Pardis Pedram, Farrell Cahill, Guangju Zhai, Edward Randell, Wayne Gulliver and Guang Sun

    Citation: Nutrition & Metabolism 2016 13:33

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  27. Content type: Research

    Apple polyphenols could represent a novel nutritional approach in the management and control of blood glucose, especially in type 2 diabetics. The aim of this study was to test the therapeutic potential of an ...

    Authors: Manuel Manzano, María D Giron, José D. Vilchez, Natalia Sevillano, Nuri El-Azem, Ricardo Rueda, Rafael Salto and Jose M. Lopez-Pedrosa

    Citation: Nutrition & Metabolism 2016 13:32

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  28. Content type: Research

    Intestinal fatty-acid binding protein (I-FABP) is expressed in epithelial cells of the mucosal layer of the small intestine tissue. When intestinal mucosal damage occurs, I-FABP is released into the circulatio...

    Authors: Eva Lau, Cláudia Marques, Diogo Pestana, Mariana Santoalha, Davide Carvalho, Paula Freitas and Conceição Calhau

    Citation: Nutrition & Metabolism 2016 13:31

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  29. Content type: Research

    Obesity is one of the greatest public health problems and major risk factors for serious metabolic diseases and significantly increases the risk of premature death. The aim of this study was to determine the i...

    Authors: Min-Sup Jung, Soo-Jung Lee, Yuno Song, Sun-Hee Jang, Wongi Min, Chung-Kil Won, Hong-Duck Kim, Tae Hoon Kim and Jae-Hyeon Cho

    Citation: Nutrition & Metabolism 2016 13:29

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  30. Content type: Review

    Hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated from the Mavolanate-Shikimate biosynthesis pathways in plants. Several simple phenolic compounds such as cinnamic acid, p-...

    Authors: Md Ashraful Alam, Nusrat Subhan, Hemayet Hossain, Murad Hossain, Hasan Mahmud Reza, Md Mahbubur Rahman and M Obayed Ullah

    Citation: Nutrition & Metabolism 2016 13:27

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  31. Content type: Research

    Little is known about the effects of dietary components on the regulation of the gastric emptying rate of alcohol and its impact on alcohol metabolism. We recently found that the crude water-insoluble dietary ...

    Authors: Shunji Oshima, Sachie Shiiya, Yoshimi Tokumaru and Tomomasa Kanda

    Citation: Nutrition & Metabolism 2016 13:25

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  32. Content type: Research

    Current criterion of waist circumference (WC) for abdominal obesity is not enough to demonstrate characteristics of obese and non-obese populations defined by BMI. The aim of this study was to redefine the cut...

    Authors: Kyung-Soo Kim, Hyun-Ju Oh, Young Ju Choi, Byung Wook Huh, Soo-Kyung Kim, Seok Won Park, Eun Jig Lee, Yong-Wook Cho and Kap-Bum Huh

    Citation: Nutrition & Metabolism 2016 13:26

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  33. Content type: Research

    Cholesterol accumulation causes pancreatic beta cell lipotoxicity and dysfunction. Cholesteryl ester transfer protein (CETP) plays an important role in blood lipid homeostasis. However, its role in tissue lipi...

    Authors: Wen Guo, Yingyun Gong, Zhenzhen Fu, Jinxiang Fu, Yan Sun, Xianxia Ju, Yina Chang, Wen Wang, Xiaohui Zhu, Beibei Gao, Xiaoyun Liu, Tao Yang and Hongwen Zhou

    Citation: Nutrition & Metabolism 2016 13:21

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  34. Content type: Research

    The liver is an important site of fat oxidation, which participates in the metabolic regulation of food intake. We showed previously that mice with genetically inactivated Acads, encoding short-chain acyl-CoA deh...

    Authors: Sujoy Ghosh, Claudia Kruger, Shawna Wicks, Jacob Simon, K. Ganesh Kumar, William D. Johnson, Randall L. Mynatt, Robert C. Noland and Brenda K. Richards

    Citation: Nutrition & Metabolism 2016 13:17

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  35. Content type: Research

    There is currently no standard clinical refeeding diet for the treatment of anorexia nervosa (AN). To provide the most efficacious AN clinical care, it is necessary to define the metabolic effects of current r...

    Authors: Erin D. Giles, Jennifer Hagman, Zhaoxing Pan, Paul S. MacLean and Janine A. Higgins

    Citation: Nutrition & Metabolism 2016 13:18

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  36. Content type: Brief communication

    Insulin regulates glucose homeostasis through direct effects on the liver, among other organs, with leptin modulating insulin’s hepatic actions. Since central leptin may modify insulin signaling in the liver, ...

    Authors: Emma Burgos-Ramos, Sandra Canelles, Laura M. Frago, Julie A. Chowen, Eduardo Arilla-Ferreiro, Jesús Argente and Vicente Barrios

    Citation: Nutrition & Metabolism 2016 13:19

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  37. Content type: Research

    Type 2 diabetes is associated with increased plasma concentrations of non-esterified fatty acids (NEFAs), which trigger pancreatic β-cell dysfunction and apoptosis. Only long-chain saturated NEFAs induced lipo...

    Authors: Thomas Plötz, Magnus Hartmann, Sigurd Lenzen and Matthias Elsner

    Citation: Nutrition & Metabolism 2016 13:16

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  38. Content type: Research

    As a result of the increased consumption of sugar-rich and fatty-products, and the increase in preference for such products, metabolic disorders are becoming more common at a younger age. Fructose is particula...

    Authors: Iona Lozano, Remmelt Van der Werf, William Bietiger, Elodie Seyfritz, Claude Peronet, Michel Pinget, Nathalie Jeandidier, Elisa Maillard, Eric Marchioni, Séverine Sigrist and Stéphanie Dal

    Citation: Nutrition & Metabolism 2016 13:15

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  39. Content type: Review

    The worldwide prevalence of obesity more than doubled between 1980 and 2014. The obesity pandemic is tightly linked to an increase in energy availability, sedentariness and greater control of ambient temperatu...

    Authors: Nazarii Kobyliak, Caterina Conte, Giovanni Cammarota, Andreana P. Haley, Igor Styriak, Ludovit Gaspar, Jozef Fusek, Luis Rodrigo and Peter Kruzliak

    Citation: Nutrition & Metabolism 2016 13:14

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  40. Content type: Research

    Resistant glucan (RG) and hydrogenated resistant glucan (HRG) are new dietary fiber materials developed to decrease the risk of metabolic syndrome and lifestyle-related diseases. We investigated the metabolism...

    Authors: Sadako Nakamura, Kenichi Tanabe, Shigeki Morita, Norihisa Hamaguchi, Fumio Shimura and Tsuneyuki Oku

    Citation: Nutrition & Metabolism 2016 13:13

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  41. Content type: Research

    Many people believe in favourable effects of branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), especially leucine, on muscle protein balance and consume BCAAs for many years. We determined t...

    Authors: Milan Holecek, Pavel Siman, Melita Vodenicarovova and Roman Kandar

    Citation: Nutrition & Metabolism 2016 13:12

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