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  1. Content type: Research

    Apple polyphenols could represent a novel nutritional approach in the management and control of blood glucose, especially in type 2 diabetics. The aim of this study was to test the therapeutic potential of an ...

    Authors: Manuel Manzano, María D Giron, José D. Vilchez, Natalia Sevillano, Nuri El-Azem, Ricardo Rueda, Rafael Salto and Jose M. Lopez-Pedrosa

    Citation: Nutrition & Metabolism 2016 13:32

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  2. Content type: Research

    Intestinal fatty-acid binding protein (I-FABP) is expressed in epithelial cells of the mucosal layer of the small intestine tissue. When intestinal mucosal damage occurs, I-FABP is released into the circulatio...

    Authors: Eva Lau, Cláudia Marques, Diogo Pestana, Mariana Santoalha, Davide Carvalho, Paula Freitas and Conceição Calhau

    Citation: Nutrition & Metabolism 2016 13:31

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  3. Content type: Research

    Obesity is one of the greatest public health problems and major risk factors for serious metabolic diseases and significantly increases the risk of premature death. The aim of this study was to determine the i...

    Authors: Min-Sup Jung, Soo-Jung Lee, Yuno Song, Sun-Hee Jang, Wongi Min, Chung-Kil Won, Hong-Duck Kim, Tae Hoon Kim and Jae-Hyeon Cho

    Citation: Nutrition & Metabolism 2016 13:29

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  4. Content type: Review

    Hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated from the Mavolanate-Shikimate biosynthesis pathways in plants. Several simple phenolic compounds such as cinnamic acid, p-...

    Authors: Md Ashraful Alam, Nusrat Subhan, Hemayet Hossain, Murad Hossain, Hasan Mahmud Reza, Md Mahbubur Rahman and M Obayed Ullah

    Citation: Nutrition & Metabolism 2016 13:27

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  5. Content type: Research

    Little is known about the effects of dietary components on the regulation of the gastric emptying rate of alcohol and its impact on alcohol metabolism. We recently found that the crude water-insoluble dietary ...

    Authors: Shunji Oshima, Sachie Shiiya, Yoshimi Tokumaru and Tomomasa Kanda

    Citation: Nutrition & Metabolism 2016 13:25

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  6. Content type: Research

    Current criterion of waist circumference (WC) for abdominal obesity is not enough to demonstrate characteristics of obese and non-obese populations defined by BMI. The aim of this study was to redefine the cut...

    Authors: Kyung-Soo Kim, Hyun-Ju Oh, Young Ju Choi, Byung Wook Huh, Soo-Kyung Kim, Seok Won Park, Eun Jig Lee, Yong-Wook Cho and Kap-Bum Huh

    Citation: Nutrition & Metabolism 2016 13:26

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  7. Content type: Research

    Cholesterol accumulation causes pancreatic beta cell lipotoxicity and dysfunction. Cholesteryl ester transfer protein (CETP) plays an important role in blood lipid homeostasis. However, its role in tissue lipi...

    Authors: Wen Guo, Yingyun Gong, Zhenzhen Fu, Jinxiang Fu, Yan Sun, Xianxia Ju, Yina Chang, Wen Wang, Xiaohui Zhu, Beibei Gao, Xiaoyun Liu, Tao Yang and Hongwen Zhou

    Citation: Nutrition & Metabolism 2016 13:21

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  8. Content type: Research

    The liver is an important site of fat oxidation, which participates in the metabolic regulation of food intake. We showed previously that mice with genetically inactivated Acads, encoding short-chain acyl-CoA deh...

    Authors: Sujoy Ghosh, Claudia Kruger, Shawna Wicks, Jacob Simon, K. Ganesh Kumar, William D. Johnson, Randall L. Mynatt, Robert C. Noland and Brenda K. Richards

    Citation: Nutrition & Metabolism 2016 13:17

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  9. Content type: Research

    There is currently no standard clinical refeeding diet for the treatment of anorexia nervosa (AN). To provide the most efficacious AN clinical care, it is necessary to define the metabolic effects of current r...

    Authors: Erin D. Giles, Jennifer Hagman, Zhaoxing Pan, Paul S. MacLean and Janine A. Higgins

    Citation: Nutrition & Metabolism 2016 13:18

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  10. Content type: Brief communication

    Insulin regulates glucose homeostasis through direct effects on the liver, among other organs, with leptin modulating insulin’s hepatic actions. Since central leptin may modify insulin signaling in the liver, ...

    Authors: Emma Burgos-Ramos, Sandra Canelles, Laura M. Frago, Julie A. Chowen, Eduardo Arilla-Ferreiro, Jesús Argente and Vicente Barrios

    Citation: Nutrition & Metabolism 2016 13:19

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  11. Content type: Research

    Type 2 diabetes is associated with increased plasma concentrations of non-esterified fatty acids (NEFAs), which trigger pancreatic β-cell dysfunction and apoptosis. Only long-chain saturated NEFAs induced lipo...

    Authors: Thomas Plötz, Magnus Hartmann, Sigurd Lenzen and Matthias Elsner

    Citation: Nutrition & Metabolism 2016 13:16

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  12. Content type: Research

    As a result of the increased consumption of sugar-rich and fatty-products, and the increase in preference for such products, metabolic disorders are becoming more common at a younger age. Fructose is particula...

    Authors: Iona Lozano, Remmelt Van der Werf, William Bietiger, Elodie Seyfritz, Claude Peronet, Michel Pinget, Nathalie Jeandidier, Elisa Maillard, Eric Marchioni, Séverine Sigrist and Stéphanie Dal

    Citation: Nutrition & Metabolism 2016 13:15

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  13. Content type: Review

    The worldwide prevalence of obesity more than doubled between 1980 and 2014. The obesity pandemic is tightly linked to an increase in energy availability, sedentariness and greater control of ambient temperatu...

    Authors: Nazarii Kobyliak, Caterina Conte, Giovanni Cammarota, Andreana P. Haley, Igor Styriak, Ludovit Gaspar, Jozef Fusek, Luis Rodrigo and Peter Kruzliak

    Citation: Nutrition & Metabolism 2016 13:14

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  14. Content type: Research

    Resistant glucan (RG) and hydrogenated resistant glucan (HRG) are new dietary fiber materials developed to decrease the risk of metabolic syndrome and lifestyle-related diseases. We investigated the metabolism...

    Authors: Sadako Nakamura, Kenichi Tanabe, Shigeki Morita, Norihisa Hamaguchi, Fumio Shimura and Tsuneyuki Oku

    Citation: Nutrition & Metabolism 2016 13:13

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  15. Content type: Research

    The brain is by far the most metabolically active organ in the body, with overall energy expenditure and local blood-supply closely related to neural activity. Both energy metabolism and cerebral vaso-dilation...

    Authors: David O. Kennedy, Emma J. Stevenson, Philippa A. Jackson, Sarah Dunn, Karl Wishart, Gregor Bieri, Luca Barella, Alexandra Carne, Fiona L. Dodd, Bernadette C. Robertson, Joanne Forster and Crystal F. Haskell-Ramsay

    Citation: Nutrition & Metabolism 2016 13:11

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  16. Content type: Research

    Many people believe in favourable effects of branched-chain amino acids (BCAAs; valine, leucine, and isoleucine), especially leucine, on muscle protein balance and consume BCAAs for many years. We determined t...

    Authors: Milan Holecek, Pavel Siman, Melita Vodenicarovova and Roman Kandar

    Citation: Nutrition & Metabolism 2016 13:12

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  17. Content type: Research

    The treatment of Irritable bowel syndrome (IBS) is still challenging. Partially hydrolyzed guar gum (PHGG) is a known prebiotic fiber. To assess the effects of PHGG on clinical symptoms of IBS patients in a pr...

    Authors: E. Niv, A. Halak, E. Tiommny, H. Yanai, H. Strul, T. Naftali and N. Vaisman

    Citation: Nutrition & Metabolism 2016 13:10

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  18. Content type: Research

    Nutritional ketosis induced by the ketogenic diet (KD) has therapeutic applications for many disease states. We hypothesized that oral administration of exogenous ketone supplements could produce sustained nut...

    Authors: Shannon L. Kesl, Angela M. Poff, Nathan P. Ward, Tina N. Fiorelli, Csilla Ari, Ashley J. Van Putten, Jacob W. Sherwood, Patrick Arnold and Dominic P. D’Agostino

    Citation: Nutrition & Metabolism 2016 13:9

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  19. Content type: Research

    Obesity increases the risk for malignancies in various tissues including the stomach. Atrophic gastritis with precancerous lesions is an obesity-associated disease; however, the mechanisms that underlie the de...

    Authors: Kyoko Inagaki-Ohara, Shiki Okamoto, Kazuyo Takagi, Kumiko Saito, Seiya Arita, Lijun Tang, Tetsuji Hori, Hiroaki Kataoka, Satoshi Matsumoto and Yasuhiko Minokoshi

    Citation: Nutrition & Metabolism 2016 13:7

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  20. Content type: Research

    It is now increasingly recognized that the beneficial effects of seafood consumption is not limited to lipids and fatty acid, but that the protein part, i.e., peptides and amino acids, together with vitamins a...

    Authors: Ida-Johanne Jensen, Mari Walquist, Bjørn Liaset, Edel O. Elvevoll and Karl-Erik Eilertsen

    Citation: Nutrition & Metabolism 2016 13:8

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  21. Content type: Research

    Previous studies suggest that intake of specific bioactive compounds may have beneficial clinical effects on adipose tissue partly due to their anti-inflammatory and insulin-sensitizing properties. With the ov...

    Authors: Christel Björk, Uta Wilhelm, Susanne Mandrup, Bjørk Ditlev Larsen, Alessandra Bordoni, Per Hedén, Mikael Rydén, Peter Arner and Jurga Laurencikiene

    Citation: Nutrition & Metabolism 2016 13:4

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  22. Content type: Research

    Amino acids (AAs) are emerging as a new class of effective molecules in the etiology of obesity and diabetes mellitus. However, most investigations have focused on subjects with obesity and/or impaired glucose...

    Authors: Chisa Takashina, Ichizo Tsujino, Taku Watanabe, Shinji Sakaue, Daisuke Ikeda, Asuka Yamada, Takahiro Sato, Hiroshi Ohira, Yoshinori Otsuka, Noriko Oyama-Manabe, Yoichi M. Ito and Masaharu Nishimura

    Citation: Nutrition & Metabolism 2016 13:5

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  23. Content type: Research

    Active metabolism of peripheral blood mononuclear cells (PBMC) could suggest their suitability for metabolomics studies. This study examined whether reductions in PBMCs and plasma lipoprotein-associated phosph...

    Authors: Minjoo Kim, Gayoung Song, Miso Kang, Hye Jin Yoo, Tae-Sook Jeong, Sang-Hyun Lee and Jong Ho Lee

    Citation: Nutrition & Metabolism 2016 13:3

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  24. Content type: Research

    Resistant starch (RS) is a type of dietary fiber that can improve glucose metabolism, but its effects may be modulated by sex or baseline insulin sensitivity. This study was designed to examine the effect of h...

    Authors: Barbara A. Gower, Richard Bergman, Darko Stefanovski, Betty Darnell, Fernando Ovalle, Gordon Fisher, S. Katherine Sweatt, Holly S. Resuehr and Christine Pelkman

    Citation: Nutrition & Metabolism 2016 13:2

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    The Erratum to this article has been published in Nutrition & Metabolism 2016 13:6

  25. Content type: Research

    Microsomal triglyceride transfer protein (MTP) is essential for the assembly of lipoproteins. MTP has been shown on the surface of lipid droplets of adipocytes; however its function in adipose tissue is not we...

    Authors: Ahmed Bakillah and M. Mahmood Hussain

    Citation: Nutrition & Metabolism 2016 13:1

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  26. Content type: Research

    Better macro and micro nutrient status and their adequate intake by the athletes have great role in balancing losses associated with strenuous exercise, then for better performance. The objective of this study...

    Authors: Kifle Habte, Abdulaziz Adish, Dilnesaw Zerfu, Aweke Kebede, Tibebu Moges, Biniyam Tesfaye, Feyissa Challa and Kaleab Baye

    Citation: Nutrition & Metabolism 2015 12:62

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  27. Content type: Research

    To investigate the relationship of the neck circumference (NC) with non-alcoholic fatty liver disease (NAFLD) in non-obese Chinese population.

    Authors: Qin Li, Ningjian Wang, Bing Han, Yi Chen, Chunfang Zhu, Yingchao Chen, Fangzhen Xia, Zhen Cang, Chaoxia Zhu, Chi Chen, Hualing Zhai, Boren Jiang, Dongping Lin and Yingli Lu

    Citation: Nutrition & Metabolism 2015 12:63

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  28. Content type: Research

    Hypertriglyceridemia is a common type of dyslipidemia found in obesity. However, it is not established whether primary hyperlipidemia can predispose to obesity. Evidences have suggested that proteins primarily...

    Authors: Helena F. Raposo, Adriene A. Paiva, Larissa S. Kato and Helena C. F. de Oliveira

    Citation: Nutrition & Metabolism 2015 12:61

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  29. Content type: Research

    Excess consumption of energy-dense, high-fat Western diets contributes to the development of obesity and obesity-related disorders, such as fatty liver disease. However, not only the quantity but also the comp...

    Authors: Sharon Janssens, Mattijs M. Heemskerk, Sjoerd A. van den Berg, Natal A. van Riel, Klaas Nicolay, Ko Willems van Dijk and Jeanine J. Prompers

    Citation: Nutrition & Metabolism 2015 12:57

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  30. Content type: Research

    Physical exercise induces positive alterations in gene expression involved in the metabolism of obesity. Maternal exercise provokes adaptations soon after birth in the offspring. Here, we investigated whether ...

    Authors: Frederick Wasinski, Reury Frank Pereira Bacurau, Gabriel Rufino Estrela, Friederike Klempin, Aline Midori Arakaki, Rogerio Oliveira Batista, Fernando Francisco Pazello Mafra, Lucas Francisco Ribeiro do Nascimento, Meire Ioshie Hiyane, Lício Augusto Velloso, Niels Olsen Saraiva Câmara and Ronaldo Carvalho Araujo

    Citation: Nutrition & Metabolism 2015 12:56

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  31. Content type: Research

    N-3 polyunsaturated fatty acids (n-3 PUFAs), in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to effectively improve hepatic steatosis and insulin resistance caused by ...

    Authors: Pengfei Xu, Huan Wang, Abudurexiti Kayoumu, Mengyu Wang, Wei Huang and George Liu

    Citation: Nutrition & Metabolism 2015 12:58

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  32. Content type: Research

    Enteroendocrine cells collectively constitute our largest endocrine tissue, with serotonin (5-HT) secreting enterochromaffin (EC) cells being the largest component (~50 %). This gut-derived 5-HT has multiple p...

    Authors: Leah Zelkas, Ravi Raghupathi, Amanda L. Lumsden, Alyce M. Martin, Emily Sun, Nick J. Spencer, Richard L. Young and Damien J. Keating

    Citation: Nutrition & Metabolism 2015 12:55

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  33. Content type: Research

    Casein-free, gluten-free diets have been reported to mitigate some of the inflammatory gastrointestinal and behavioral traits associated with autism, but the mechanism for this palliative effect has not been e...

    Authors: Malav S. Trivedi, Nathaniel W. Hodgson, Stephen J. Walker, Geert Trooskens, Vineeth Nair and Richard C. Deth

    Citation: Nutrition & Metabolism 2015 12:54

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  34. Content type: Research

    Several studies in both humans and rodents have examined the use of lactoferrin as a dietary solution to weight gain and visceral fat accretion and have shown promising results in the short term (up to 7 weeks...

    Authors: Bettina McManus, Riitta Korpela, Paula O’Connor, Harriet Schellekens, John F. Cryan, Paul D. Cotter and Kanishka N. Nilaweera

    Citation: Nutrition & Metabolism 2015 12:53

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  35. Content type: Research

    The marine n-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) exert numerous beneficial effects on health, but their potency to improve treatment of type 2 diabetic (T2D) patients remains...

    Authors: Jiri Veleba, Jan Kopecky Jr., Petra Janovska, Ondrej Kuda, Olga Horakova, Hana Malinska, Ludmila Kazdova, Olena Oliyarnyk, Vojtech Skop, Jaroslava Trnovska, Milan Hajek, Antonin Skoch, Pavel Flachs, Kristina Bardova, Martin Rossmeisl, Josune Olza…

    Citation: Nutrition & Metabolism 2015 12:52

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  36. Content type: Review

    The number of obese patients has increased annually worldwide. Therefore, there is a strong need to develop a new effective and safe anti-obesity drug. Miglitol is an alpha-glucosidase inhibitor (αGI) that is ...

    Authors: Satoru Sugimoto, Hisakazu Nakajima, Kitaro Kosaka and Hajime Hosoi

    Citation: Nutrition & Metabolism 2015 12:51

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  37. Content type: Research

    Visceral fat area (VFA), a novel sex-specific index for visceral fat obesity (VFO) might play a major role in the development of vitamin D deficiency. However, the association between VFA and vitamin D insuffi...

    Authors: Meilin Zhang, Ping Li, Yufeng Zhu, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang and Guowei Huang

    Citation: Nutrition & Metabolism 2015 12:50

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  38. Content type: Review

    Cellular metabolic changes during chronic kidney disease (CKD) may induce higher production of oxygen radicals that play a significant role in the progression of renal damage and in the onset of important como...

    Authors: Simona Granata, Alessandra Dalla Gassa, Paola Tomei, Antonio Lupo and Gianluigi Zaza

    Citation: Nutrition & Metabolism 2015 12:49

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  39. Content type: Research

    From a health promotion perspective, the use of dietary indices is preferred above single nutrients and foods to evaluate diet quality. Longitudinal research about the association between dietary indices and r...

    Authors: Evelien Mertens, Benedicte Deforche, Patrick Mullie, Johan Lefevre, Ruben Charlier, Sara Knaeps, Inge Huybrechts and Peter Clarys

    Citation: Nutrition & Metabolism 2015 12:47

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  40. Content type: Methodology

    The most common methods for obtaining human resting metabolic rate (RMR) use either a ventilated hood connected to a metabolic cart (VH_MC) or calculation by many prediction equations utilizing the person’s he...

    Authors: Russell Rising, Kathryn Whyte, Jeanine Albu and Xavier Pi-Sunyer

    Citation: Nutrition & Metabolism 2015 12:46

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